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zansecimab   Click here for help

GtoPdb Ligand ID: 11334

Synonyms: LY-3127804 | LY3127804
Compound class: Antibody
Comment: Zansecimab (LY3127804) is a humanised IgG4 monoclonal antibody that targets angiopoietin 2 (Ang2). It was designed and developed by Eli Lilly to block angiogenesis as an anti-tumour mechanism. As Ang2 is elevated in acute respiratory distress syndrome (ARDS), Eli Lilly chose to evaluate LY3127804 in patients hospitalised with COVID-19 pneumonia, to ascertain if this approach could reduce the risk of developing ARDS in at risk patients. The COVID study was terminated for futility after around 6 months.
The peptide chain sequences of zansecimab (from its INN submission) are identical to sequences claimed in Eli Lilly's patent WO2015179166A1: sequences 2 and 4 comprise the heavy and light chains of the mAb designated as 'Antibody A' in the patent [1].
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
11797 zansecimab
Synonyms Click here for help
LY-3127804 | LY3127804
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 1112
Other databases
GtoPdb PubChem SID 434321769
Search PubMed clinical trials zansecimab
Search PubMed titles zansecimab
Search PubMed titles/abstracts zansecimab