alunacedase alfa   Click here for help

GtoPdb Ligand ID: 11320

Synonyms: APN01 | GSK-2586881 | GSK2586881 | rhsACE2
Compound class: Peptide or derivative
Comment: Alunacedase alfa (APN01; Aperion Biologics) is a recombinant version of human ACE2 that is intended to act as a decoy (soluble trap) for the SARS-CoV-2 spike protein [1,4-5], than can neutralise the virus [4]. Recombinant ACE2 was originally proposed as a mechanism to combat acute respiratory distress syndrome (ARDS) caused by the SARS-CoV virus [2], which like SARS-CoV-2 uses ACE2 to infect host cells. Structurally APN01 is a glycosylated dimer of peptide chains that form the extracellular domain of the enzyme. It is produced in Chinese hamster ovary (CHO) cells, and it contains several intra-subunit disulphide bridges.
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
11856 alunacedase alfa
Synonyms Click here for help
APN01 | GSK-2586881 | GSK2586881 | rhsACE2
Database Links Click here for help
GtoPdb PubChem SID 434321755
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