NPS(1-4)NH2   Click here for help

GtoPdb Ligand ID: 11226

Synonyms: peptide 3 [PMID: 28267583] | PEPTIDE1{S.F.R.N.[am]}$$$$
Compound class: Peptide
Comment: This is a tetrapeptide truncation of human neuropeptide S (NPS) [1]. It exhibits agonist bias for calcium mobilisation compared to cAMP accumulation in vitro.
HELM annotation is PEPTIDE1{S.F.R.N.[am]}$$$$.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CC(=O)N)CCCNC(=N)N)Cc1ccccc1)N
Isomeric SMILES OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)CC(=O)N)CCCNC(=N)N)Cc1ccccc1)N
InChI InChI=1S/C22H35N9O6/c23-13(11-32)19(35)31-16(9-12-5-2-1-3-6-12)21(37)29-14(7-4-8-28-22(26)27)20(36)30-15(18(25)34)10-17(24)33/h1-3,5-6,13-16,32H,4,7-11,23H2,(H2,24,33)(H2,25,34)(H,29,37)(H,30,36)(H,31,35)(H4,26,27,28)/t13-,14-,15-,16-/m0/s1
InChI Key VWBPRJXOZDIUPZ-VGWMRTNUSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Clark SD, Kenakin TP, Gertz S, Hassler C, Gay EA, Langston TL, Reinscheid RK, Runyon SP. (2017)
Identification of the first biased NPS receptor agonist that retains anxiolytic and memory promoting effects with reduced levels of locomotor stimulation.
Neuropharmacology, 118: 69-78. [PMID:28267583]