concizumab   Click here for help

GtoPdb Ligand ID: 11182

Synonyms: Alhemo® | Anti-TFPI | concizumab-mtci | mab2021 | NN7415
Approved drug
concizumab is an approved drug (Health Canada (2023), FDA (2024))
Compound class: Antibody
Comment: Concizumab is a clinical stage anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody. It is a humanised IgG4 construct that was developed by Novo Nordisk as a novel therapeutic for genetic bleeding disorders [2]. Concizumab binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI and blocks its interaction with the active site of FXa [1]. TFPI is an endogenous anticoagulant protein whose pharmacological inhibition restores hemostasis [7].
Classification Click here for help
Compound class Antibody
Approved drug? Yes. Health Canada (2023)  |  FDA (2024)  |  EMA (2024)
International Nonproprietary Names Click here for help
INN number INN
9636 concizumab
Synonyms Click here for help
Alhemo® | Anti-TFPI | concizumab-mtci | mab2021 | NN7415
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 447
Other databases
GtoPdb PubChem SID 434122242
Search PubMed clinical trials concizumab
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