nojirimycin   Click here for help

GtoPdb Ligand ID: 10951

Synonyms: 5-amino-5-deoxy-D-glucopyranose | D-gluco-piperidinose
Compound class: Natural product
Comment: Nojirimycin is an aminoglycoside antibacterial with Gram-negative activity [1]. It is produced by Streptomyces species, and chemically is an iminosugar.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 6
Rotatable bonds 1
Topological polar surface area 113.18
Molecular weight 179.08
XLogP -1.03
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES OC[C@H]1NC(O)[C@@H]([C@H]([C@@H]1O)O)O
Isomeric SMILES OC[C@H]1NC(O)[C@@H]([C@H]([C@@H]1O)O)O
InChI InChI=1S/C6H13NO5/c8-1-2-3(9)4(10)5(11)6(12)7-2/h2-12H,1H2/t2-,3-,4+,5-,6?/m1/s1
InChI Key BGMYHTUCJVZIRP-GASJEMHNSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Natural product
IUPAC Name Click here for help
(3R,4S,5R,6R)-6-(hydroxymethyl)piperidine-2,3,4,5-tetrol
Synonyms Click here for help
5-amino-5-deoxy-D-glucopyranose | D-gluco-piperidinose
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Nojirimycin
Other databases
BindingDB Ligand 50371136
CAS Registry No. 15218-38-9 (source: PubChem)
ChEBI CHEBI:28945
ChEMBL Ligand CHEMBL120638
GtoPdb PubChem SID 405560392
PubChem CID 65242
Search Google for chemical match using the InChIKey BGMYHTUCJVZIRP-GASJEMHNSA-N
Search Google for chemicals with the same backbone BGMYHTUCJVZIRP
UniChem Compound Search for chemical match using the InChIKey BGMYHTUCJVZIRP-GASJEMHNSA-N
UniChem Connectivity Search for chemical match using the InChIKey BGMYHTUCJVZIRP-GASJEMHNSA-N