ChEMBL ligand: CHEMBL583042
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] There should be some charts here, you may need to enable JavaScript!
citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] There should be some charts here, you may need to enable JavaScript!
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] There should be some charts here, you may need to enable JavaScript!
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] There should be some charts here, you may need to enable JavaScript!
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] There should be some charts here, you may need to enable JavaScript!
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] There should be some charts here, you may need to enable JavaScript!
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 14/Mitogen-activated protein kinase kinase kinase 14 in Human [ChEMBL: CHEMBL5888] [GtoPdb: 2074] [UniProtKB: Q99558] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase kinase kinase 8/Mitogen-activated protein kinase kinase kinase 8 in Human [ChEMBL: CHEMBL4899] [GtoPdb: 2083] [UniProtKB: P41279] There should be some charts here, you may need to enable JavaScript!
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118] There should be some charts here, you may need to enable JavaScript!
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] There should be some charts here, you may need to enable JavaScript!
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] There should be some charts here, you may need to enable JavaScript!
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141] There should be some charts here, you may need to enable JavaScript!
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] There should be some charts here, you may need to enable JavaScript!
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] There should be some charts here, you may need to enable JavaScript!
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] There should be some charts here, you may need to enable JavaScript!
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] There should be some charts here, you may need to enable JavaScript!
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a PRKACA	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578]
ChEMBL	Inhibition of CIT	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a CIT	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779]
ChEMBL	Inhibition of JNK3	B	5.85	pKi	1400	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAPK10	B	5.85	pKi	1400	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2	B	6.07	pKi	852	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
GtoPdb	-	-	6.07	pKi	852	nM	Ki	J Med Chem (2009) 52: 6362-8 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a CDK2	B	6.07	pKi	850	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750]
ChEMBL	Inhibition of MEK1	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAP2K1	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397]
ChEMBL	Inhibition of FAK	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a PTK2	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a GSK3A	B	6.4	pKi	400	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581]
ChEMBL	Inhibition of MET	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MET	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164]
ChEMBL	Inhibition of IKKi	B	5.3	pKi	>5000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a IKBKE	B	5.3	pKi	>5000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL	Inhibition of IRAK1	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a IRAK1	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3]
ChEMBL	Inhibition of IRAK4	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a IRAK4	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
ChEMBL	Affinity Biochemical interaction: (Enzymatic assay) EUB0000604a MAPK3	B	8.7	pKi	<2	nM	Ki	Affinity Biochemical Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Inhibition of ERK2 after 10 mins by spectrophotometric coupled-enzyme assay	B	8.7	pKi	<2	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Affinity Biochemical interaction: (Enzymatic assay) EUB0000604a MAPK1	B	8.7	pKi	<2	nM	Ki	Affinity Biochemical Literature for EUbOPEN Chemogenomic Library
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAPK1	B	8.7	pKi	<2	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
GtoPdb	-	-	8.7	pKi	<2	nM	Ki	J Med Chem (2009) 52: 6362-8 [PMID:19827834]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of P38alpha	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAPK14	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779]
ChEMBL	Inhibition of MLK2	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAP3K10	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase kinase kinase 14/Mitogen-activated protein kinase kinase kinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5888] [GtoPdb: 2074] [UniProtKB: Q99558]
ChEMBL	Inhibition of NIK	B	5.3	pKi	>5000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAP3K14	B	5.3	pKi	>5000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759]
ChEMBL	Inhibition of MEKK3	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAP3K3	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318]
ChEMBL	Inhibition of TAK1	B	5.52	pKi	3000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAP3K7	B	5.52	pKi	3000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
mitogen-activated protein kinase kinase kinase 8/Mitogen-activated protein kinase kinase kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4899] [GtoPdb: 2083] [UniProtKB: P41279]
ChEMBL	Inhibition of COT	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a MAP3K8	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
pyruvate dehydrogenase kinase 1/Pyruvate dehydrogenase kinase isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4766] [GtoPdb: 2915] [UniProtKB: Q15118]
ChEMBL	Inhibition of PDK1	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a PDK1	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464]
ChEMBL	Inhibition of ROCK1	B	5.85	pKi	1400	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a ROCK1	B	5.85	pKi	1400	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243]
ChEMBL	Inhibition of AKT3	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a AKT3	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Inhibition of AURA	B	6.27	pKi	540	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a STK6	B	6.27	pKi	540	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
GtoPdb	-	-	6.27	pKi	540	nM	Ki	J Med Chem (2009) 52: 6362-8 [PMID:19827834]
polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350]
ChEMBL	Inhibition of PLK1	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a PLK1	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
serum/glucocorticoid regulated kinase 1/Serine/threonine-protein kinase Sgk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2343] [GtoPdb: 1534] [UniProtKB: O00141]
ChEMBL	Inhibition of SGK1	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a SGK1	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
ChEMBL	Inhibition of NAK	B	5	pKi	>10000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a TBK1	B	5	pKi	>10000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881]
ChEMBL	Inhibition of ITK	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a ITK	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674]
ChEMBL	Inhibition of JAK2	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a JAK2	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333]
ChEMBL	Inhibition of JAK3	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a JAK3	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL	Inhibition of FLT3	B	5.85	pKi	1400	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a FLT3	B	5.85	pKi	1400	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of SRC	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a SRC	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of SYK	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a SYK	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403]
ChEMBL	Inhibition of ZAP70	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a ZAP70	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of KDR	B	5.4	pKi	>4000	nM	Ki	J Med Chem (2009) 52: 6362-6368 [PMID:19827834]
ChEMBL	Selectivity interaction (Kinase counterscreening (biochemical assay)) EUB0000604a KDR	B	5.4	pKi	>4000	nM	Ki	Selectivity Literature for EUbOPEN Chemogenomic Library

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]