beta-carboline [Ligand Id: 8222] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL275224 (beta-carboline, norharman, norharmane)
  • acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
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  • indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
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  • component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
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  • tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of AChE (unknown origin) B 4.4 pIC50 >40000 nM IC50 J Med Chem (2021) 64: 1392-1422 [PMID:33528252]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of BuChE (unknown origin) B 4.4 pIC50 >40000 nM IC50 J Med Chem (2021) 64: 1392-1422 [PMID:33528252]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL Inhibitory activity against CKII kinase. B 4.6 pIC50 >25000 nM IC50 Bioorg Med Chem Lett (2003) 13: 2419-2422 [PMID:12824047]
Chitinase in Onchocerca volvulus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795119] [UniProtKB: Q25615]
ChEMBL Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone measured for 10 mins by fluorescence assay B 5.07 pIC50 8460 nM IC50 ACS Med Chem Lett (2015) 6: 339-343 [PMID:25815157]
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387]
ChEMBL Inhibition of Topoisomerase 1 (unknown origin) B 4.51 pIC50 31000 nM IC50 Eur J Med Chem (2021) 224: 113688-113688 [PMID:34332400]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Inhibition of DYRK1A (unknown origin) B 5.74 pIC50 >1800 nM IC50 J Med Chem (2021) 64: 1392-1422 [PMID:33528252]
GABAA receptor π subunit/GABAA receptor δ subunit/GABAA receptor α1 subunit/GABAA receptor β1 subunit/GABAA receptor γ2 subunit/GABAA receptor β3 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor α2 subunit/GABAA receptor β2 subunit/GABAA receptor α4 subunit/GABAA receptor ε subunit/GABAA receptor α6 subunit/GABAA receptor γ1 subunit/GABAA receptor γ3 subunit/GABAA receptor θ subunit/GABA-A receptor; anion channel in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093872] [GtoPdb: 419, 416, 404, 410, 414, 412, 408, 406, 405, 411, 407, 417, 409, 413, 415, 418] [UniProtKB: O00591, O14764, P14867, P18505, P18507, P28472, P31644, P34903, P47869, P47870, P48169, P78334, Q16445, Q8N1C3, Q99928, Q9UN88]
ChEMBL Inhibition on Benzodiazepine receptor B 5.79 pIC50 1621.81 nM IC50 J Med Chem (1997) 40: 4360-4371 [PMID:9435905]
ChEMBL Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay B 5.8 pIC50 1600 nM IC50 J Med Chem (2021) 64: 1392-1422 [PMID:33528252]
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14]
ChEMBL In vitro inhibition of [3H]diazepam binding to benzodiazepine receptor in rat cerebral cortical membrane B 5.79 pKi 1620 nM Ki J Med Chem (1982) 25: 1081-1091 [PMID:6127411]
ChEMBL Binding affinity for rat benzodiazepine receptor inverse agonist site B 5.79 pIC50 1621.81 nM IC50 J Med Chem (1996) 39: 2129-2140 [PMID:8667357]
ChEMBL Binding affinity towards benzodiazepine receptor inverse agonist site by the displacement of [3H]diazepam in rat cerebral cortical membranes. B 5.79 pIC50 1621.81 nM IC50 J Med Chem (1993) 36: 2929-2937 [PMID:8411009]
ChEMBL In vitro inhibition of binding to the benzodiazepine receptor in rat cerebral cortical membrane using [3H]diazepam as radioligand B 5.79 pIC50 1620 nM IC50 J Med Chem (1988) 31: 1854-1861 [PMID:2842507]
ChEMBL In vitro inhibition of 3[H]Diazepam binding to Benzodiazepine receptor from rat cerebral cortical membranes B 5.79 pIC50 1620 nM IC50 J Med Chem (1990) 33: 2343-2357 [PMID:2167977]
indoleamine 2,3-dioxygenase 1/Indoleamine 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4685] [GtoPdb: 2829] [UniProtKB: P14902]
GtoPdb - - 0.92 pKi 120000000 nM Ki Bioorg Med Chem (2011) 19: 1550-61 [PMID:21269836]
ChEMBL Inhibition of IDO B 6.92 pKi 120 nM Ki Bioorg Med Chem (2011) 19: 1550-1561 [PMID:21269836]
ChEMBL Inhibition of His-tagged recombinant human IDO1 expressed in Escherichia coli using tryptophan as substrate by spectrophotometric analysis B 4.05 pIC50 90000 nM IC50 Bioorg Med Chem (2012) 20: 1354-1363 [PMID:22112538]
component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111]
ChEMBL Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylation assay. B 4.82 pIC50 15000 nM IC50 Bioorg Med Chem Lett (2003) 13: 2419-2422 [PMID:12824047]
Monoamine oxidase A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1951] [GtoPdb: 2489] [UniProtKB: P21397]
ChEMBL Competitive inhibition of recombinant human MAO-A using kynuramine as substrate by Lineweaver-Burk plot analysis B 6.59 pKi 260 nM Ki Bioorg Med Chem Lett (2018) 28: 2403-2407 [PMID:29925480]
Monoamine oxidase B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2039] [GtoPdb: 2490] [UniProtKB: P27338]
ChEMBL Reversible inhibition of MAO-B B 5.92 pKi 1200 nM Ki Bioorg Med Chem (2011) 19: 7416-7424 [PMID:22071524]
ChEMBL Competitive inhibition of recombinant human MAO-B expressed in baculovirus system using kynuramine as substrate after 40 mins by Lineweaver-Burk plot analysis B 5.95 pKi 1120 nM Ki Bioorg Med Chem Lett (2016) 26: 4714-4719 [PMID:27575476]
tryptophan 2,3-dioxygenase/Tryptophan 2,3-dioxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2140] [GtoPdb: 2887] [UniProtKB: P48775]
ChEMBL Inhibition of TDO (unknown origin) assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate incubated for 75 mins by UV absorbance based analysis B 5.92 pIC50 1200 nM IC50 J Med Chem (2022) 65: 11214-11228 [PMID:35938398]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]