gallic acid [Ligand Id: 5549] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL288114 (Benzoic acid, 3,4,5-trihydroxy-, Gallate, Gallic acid, NSC-20103, NSC-674319) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Alpha-(1,3)-fucosyltransferase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3596077] [UniProtKB: Q11130] | ||||||||
| ChEMBL | Inhibition of FucT-7 (unknown origin) | B | 7.22 | pIC50 | 60 | nM | IC50 | Medchemcomm (2014) 5: 1106-1125 |
| Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265] | ||||||||
| ChEMBL | Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry | B | 0.72 | pIC50 | 0.72 | - | logIC50 | Med Chem Res (2012) 21: 3984-3993 |
| synuclein alpha/Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [GtoPdb: 3285] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of alpha-synuclein (unknown origin) aggregation incubated for 3 days by thioflavin T based fluorescence assay | B | 5.35 | pIC50 | 4430 | nM | IC50 | Bioorg Med Chem (2020) 28: 115596-115596 [PMID:32631566] |
| Autoinducer 2-binding periplasmic protein luxP in Vibrio harveyi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6100] [UniProtKB: P54300] | ||||||||
| ChEMBL | Antagonist activity at LuxP receptor in Vibrio harveyi MM32 assessed as inhibition of autoinducer-2-mediated quorum sensing after 3 to 4 hrs | F | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 1567-1572 [PMID:18262415] |
| Carbonic anhydrase in Dicentrarchus labrax (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795125] [UniProtKB: Q2PCB5] | ||||||||
| ChEMBL | Inhibition of Dicentrarchus labrax CA using 4-nitrophenylacetate substrate by esterase assay | B | 5.38 | pKi | 4130 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 4259-4262 [PMID:21669522] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human CA1 by stopped-flow CO2 hydration assay | B | 5.49 | pKi | 3200 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| GtoPdb | - | - | 5.5 | pKi | 3200 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-64 [PMID:20185318] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human CA2 by stopped-flow CO2 hydration assay | B | 5.65 | pKi | 2250 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human CA3 by stopped-flow CO2 hydration assay | B | 5.13 | pKi | 7490 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human CA4 by stopped-flow CO2 hydration assay | B | 5.01 | pKi | 9800 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human CA9 by stopped-flow CO2 hydration assay | B | 5.16 | pKi | 6990 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human CA5A by stopped-flow CO2 hydration assay | B | 5.39 | pKi | 4080 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human CA5B by stopped-flow CO2 hydration assay | B | 5 | pKi | 9970 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human CA6 by stopped-flow CO2 hydration assay | B | 5.21 | pKi | 6130 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human CA7 by stopped-flow CO2 hydration assay | B | 5.22 | pKi | 6070 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human CA12 by stopped-flow CO2 hydration assay | B | 5.11 | pKi | 7780 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse CA13 by stopped-flow CO2 hydration assay | B | 5.01 | pKi | 9860 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human CA14 by stopped-flow CO2 hydration assay | B | 5.15 | pKi | 7030 | nM | Ki | Bioorg Med Chem (2010) 18: 2159-2164 [PMID:20185318] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of DPP4 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 4 secs followed by substrate addition and measured after 30 mins by luminescence assay | B | 5.33 | pIC50 | 4650 | nM | IC50 | Eur J Med Chem (2018) 151: 145-157 [PMID:29609120] |
| Fucosyltransferase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4996] [UniProtKB: P22083] | ||||||||
| ChEMBL | Inhibition of FucT-4 (unknown origin) | B | 4.85 | pIC50 | 14000 | nM | IC50 | Medchemcomm (2014) 5: 1106-1125 |
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibition of polymerization in wild type HIV-1 RT with poly rC/dG12-18 template primer and [3H]dGTP | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2763-2767 [PMID:11591519] |
| Leukocyte adhesion molecule-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3161] [UniProtKB: P14151] | ||||||||
| ChEMBL | Inhibition of human L-selectin after 2 hrs | B | 4.56 | pIC50 | 27600 | nM | IC50 | J Med Chem (2007) 50: 1101-1115 [PMID:17302397] |
| Inducible NOS/Nitric oxide synthase, inducible in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3464] [GtoPdb: 1250] [UniProtKB: P29477] | ||||||||
| ChEMBL | Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2008) 16: 9867-9870 [PMID:18926710] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as intraerythrocytic growth inhibition | F | 4.17 | pIC50 | 68000 | nM | IC50 | RSC Med Chem (2023) 14: 715-733 [PMID:37122550] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as inhibition of parasite reduction by giemsa staining based analysis | F | 4.17 | pIC50 | 68000 | nM | IC50 | RSC Med Chem (2023) 14: 715-733 [PMID:37122550] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as inhibition of parasite reduction by giemsa staining based analysis | F | 5 | pIC50 | >10000 | nM | IC50 | RSC Med Chem (2023) 14: 715-733 [PMID:37122550] |
| Polypeptide N-acetylgalactosaminyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3713355] [UniProtKB: Q10471] | ||||||||
| ChEMBL | Binding affinity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293 cells assessed as dissociation constant by SPR analysis | B | 6.03 | pKd | 924 | nM | Kd | Bioorg Med Chem (2019) 27: 3372-3382 [PMID:31227364] |
| ChEMBL | Inhibition of catalytic activity of human recombinant FLAG-tagged ppGalNAcT2 expressed in HEK293T cells and using 5-FAM labelled-EA2 peptide as substrate incubated for 30 mins by HPLC-based enzyme assay | B | 5.86 | pIC50 | 1370 | nM | IC50 | Bioorg Med Chem (2019) 27: 3372-3382 [PMID:31227364] |
| selectin P (CD62)/P-selectin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5378] [GtoPdb: 3103] [UniProtKB: P16109] | ||||||||
| ChEMBL | Inhibition of human P-selectin after 2 hrs | B | 4.72 | pIC50 | 19100 | nM | IC50 | J Med Chem (2007) 50: 1101-1115 [PMID:17302397] |
| squalene monooxygenase/Squalene monooxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4241] [GtoPdb: 2433] [UniProtKB: P52020] | ||||||||
| ChEMBL | Inhibition of C-terminal hexahistidine-tagged rat recombinant squalene epoxidase without N-terminal putative membrane domain expressed in Escherichia coli | B | 4.14 | pIC50 | 73000 | nM | IC50 | J Nat Prod (2001) 64: 1010-1014 [PMID:11520216] |
| TLR2/Toll-like receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075106] [GtoPdb: 1752] [UniProtKB: Q9QUN7] | ||||||||
| ChEMBL | Antagonist activity at TLR2 in mouse RAW264.7 cells assessed as PAM3CSK4-induced NO production measured after 24 hrs by Griess assay | B | 4.16 | pIC50 | 69250 | nM | IC50 | Eur J Med Chem (2019) 179: 233-245 [PMID:31255924] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
