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carbonic anhydrase 13

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Target id: 2748

Nomenclature: carbonic anhydrase 13

Abbreviated Name: CA XIII

Family: Carbonic anhydrases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 262 8q21.2 CA13 carbonic anhydrase 13
Mouse - 262 3 A1 Car13 carbonic anhydrase 13
Rat - 262 2q23 Car13 carbonic anhydrase 13
Previous and Unofficial Names Click here for help
carbonic anhydrase XIII
Database Links Click here for help
Alphafold Q8N1Q1 (Hs), Q9D6N1 (Mm)
BRENDA 4.2.1.1
CATH/Gene3D 3.10.200.10
ChEMBL Target CHEMBL3912 (Hs), CHEMBL2186 (Mm)
Ensembl Gene ENSG00000185015 (Hs), ENSMUSG00000027555 (Mm)
Entrez Gene 377677 (Hs), 71934 (Mm), 499566 (Rn)
Human Protein Atlas ENSG00000185015 (Hs)
KEGG Enzyme 4.2.1.1
KEGG Gene hsa:377677 (Hs), mmu:71934 (Mm), rno:499566 (Rn)
OMIM 611436 (Hs)
Pharos Q8N1Q1 (Hs)
RefSeq Nucleotide NM_198584 (Hs), NM_024495 (Mm), NM_001134993 (Rn)
RefSeq Protein NP_940986 (Hs), NP_078771 (Mm), NP_001128465 (Rn)
UniProtKB Q8N1Q1 (Hs), Q9D6N1 (Mm)
Wikipedia CA13 (Hs)
Enzyme Reaction Click here for help
EC Number: 4.2.1.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
acetazolamide Small molecule or natural product Approved drug Ligand has a PDB structure Mm Inhibition 7.8 pKi 1
⤷ pKi 7.8 (Ki 1.7x10-8 M) [1]

References

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1. Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. (2010) Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg Med Chem Lett, 20 (15): 4376-81. [PMID:20605094]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 13. Last modified on 29/11/2018. Accessed on 26/10/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2748.