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Target id: 2598
Nomenclature: carbonic anhydrase 14
Abbreviated Name: CA XIV
Family: Carbonic anhydrases
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 1 | 337 | 1q21.2 | CA14 | carbonic anhydrase 14 | |
Mouse | 1 | 337 | 3 F2.1 | Car14 | carbonic anhydrase 14 | |
Rat | 1 | 337 | 2q34 | Car14 | carbonic anhydrase 14 |
Previous and Unofficial Names |
carbonic anhydrase XIV | Car14 | Ca14 |
Database Links | |
Alphafold | Q9ULX7 (Hs), Q9WVT6 (Mm), A2IBE0 (Rn) |
BRENDA | 4.2.1.1 |
CATH/Gene3D | 3.10.200.10 |
ChEMBL Target | CHEMBL3510 (Hs) |
DrugBank Target | Q9ULX7 (Hs) |
Ensembl Gene | ENSG00000118298 (Hs), ENSMUSG00000038526 (Mm), ENSRNOG00000023162 (Rn) |
Entrez Gene | 23632 (Hs), 23831 (Mm), 791259 (Rn) |
Human Protein Atlas | ENSG00000118298 (Hs) |
KEGG Enzyme | 4.2.1.1 |
KEGG Gene | hsa:23632 (Hs), mmu:23831 (Mm), rno:791259 (Rn) |
OMIM | 604832 (Hs) |
Pharos | Q9ULX7 (Hs) |
RefSeq Nucleotide | NM_012113 (Hs), NM_011797 (Mm), NM_001109655 (Rn) |
RefSeq Protein | NP_036245 (Hs), NP_035927 (Mm), NP_001103125 (Rn) |
SynPHARM | 78867 (in complex with acetazolamide) |
UniProtKB | Q9ULX7 (Hs), Q9WVT6 (Mm), A2IBE0 (Rn) |
Wikipedia | CA14 (Hs) |
Enzyme Reaction | ||||
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Download all structure-activity data for this target as a CSV file
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Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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Acetazolamide inhibits carbonic anhydrases I, IV and XIV, but has 10-fold lower affinity for XIV. Methazolamide inhibits carbonic anhydrases I, IV and XIV with similar affinity. Chlorthalidone is an approved drug inhibitor of carbonic anhydrase activity. We have tagged CA VII and XII as the primary targets for this drug as affinity is highest at these two isozymes [6]. . |
1. Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. (2010) Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg Med Chem Lett, 20 (15): 4376-81. [PMID:20605094]
2. Garaj V, Puccetti L, Fasolis G, Winum JY, Montero JL, Scozzafava A, Vullo D, Innocenti A, Supuran CT. (2004) Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorg Med Chem Lett, 14 (21): 5427-33. [PMID:15454239]
3. Innocenti A, Firnges MA, Antel J, Wurl M, Scozzafava A, Supuran CT. (2005) Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett, 15 (4): 1149-54. [PMID:15686931]
4. Nishimori I, Vullo D, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT. (2005) Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides. Bioorg Med Chem Lett, 15 (17): 3828-33. [PMID:16039848]
5. Parr JS, Khalifah RG. (1992) Inhibition of carbonic anhydrases I and II by N-unsubstituted carbamate esters. J Biol Chem, 267 (35): 25044-50. [PMID:1460006]
6. Temperini C, Cecchi A, Scozzafava A, Supuran CT. (2009) Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem, 17 (3): 1214-21. [PMID:19119014]
7. Temperini C, Scozzafava A, Vullo D, Supuran CT. (2006) Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry, 12 (27): 7057-66. [PMID:16807956]
Carbonic anhydrases: carbonic anhydrase 14. Last modified on 25/07/2019. Accessed on 13/11/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetomalariapharmacology.org/GRAC/ObjectDisplayForward?objectId=2598.