paracetamol [Ligand Id: 5239] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL112 (Abdine, Acephen, Acetaminophen, Alvedon, Angiers, Apap, Biocetamol, Calpol, Calpol six plus, Calpol six plus fastmelts, Child lemsip, Cupanol, Dafalgan, Datril, Disprol, Disprol infant, Disprol jnr, Disprol paed, Doliprane, Efferalgan, Fennings, Galpamol, Hedex, Infadrops, Infants' feverall, Injectapap, Junior parapaed, Mandanol, Medinol, Medinol for children, Medinol over 6, Medinol under 6, Medised plain, Miradol, N-acetyl-p-aminophenol, Neopap, NSC-109028, NSC-3991, Ofirmev, Paldesic, Panadol, Panadol actifast, Panadol actifast solb, Panadol advan, Panadol jnr, Panadol oa, Panaleve, Panaleve 6 plus, Paracetamol, Paracetamolum, Paramin, Parapaed jnr, Parapaed six plus, Paravict, Perfalgan, Phenaphen, P-hydroxy-acetanilid, Placidex, Rimadol, Salzone, Tixymol, Tramil 500, Tylenol, Vermidon) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-lipoxygenase activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4550] [UniProtKB: P20292] | ||||||||
| ChEMBL | Inhibition of FLAP | B | 4.36 | pIC50 | 44000 | nM | IC50 | J Med Chem (2008) 51: 4059-4067 [PMID:18459759] |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | B | 4.55 | pIC50 | 28380 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885] | ||||||||
| ChEMBL | Inhibition of 3F-Tyr-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli by isothermal titration calorimetry | B | 3.6 | pKd | 250000 | nM | Kd | Medchemcomm (2015) 6: 1587-1604 |
| ChEMBL | Inhibition of 5F-Trp-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli by isothermal titration calorimetry | B | 3.6 | pKd | 250000 | nM | Kd | Medchemcomm (2015) 6: 1587-1604 |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay | B | 5.03 | pKi | 9230 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 5 | pKi | 10000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 5 | pKi | 10000 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 5 | pKi | 10000 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 5.21 | pKi | 6200 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 3593-3596 [PMID:18501600] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 5.21 | pKi | 6200 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 5.21 | pKi | 6200 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662] |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 3 by stopped-flow CO2 hydration assay | B | 5.15 | pKi | 7100 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay | B | 4.94 | pKi | 11400 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay | B | 4.15 | pKi | 70700 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay | B | 4.15 | pKi | 70700 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5636-5641 [PMID:26520662] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay | B | 5.04 | pKi | 9100 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay | B | 5.39 | pKi | 4100 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay | B | 4.52 | pKi | 30300 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay | B | 4.97 | pKi | 10600 | nM | Ki | Bioorg Med Chem (2008) 16: 7424-7428 [PMID:18579385] |
| CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
| ChEMBL | Inhibition Assay: Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.3%) are incubated with human liver microsomes (0.25 mg/mL) and NADPH (1 mM) in the presence of the probe substrate ethoxyresorufin (0.5 μM) for 5 min at 37° C. The selective CYP1A inhibitor, alpha-naphthoflavone, is screened alongside the test compounds as a positive control. | B | 4.6 | pIC50 | >25000 | nM | IC50 | US-9333197-B2. Apoptosis signal-regulating kinase inhibitor (2016) |
| Myoglobin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2406892] [UniProtKB: P02144] | ||||||||
| ChEMBL | Inhibition of myoglobin (unknown origin)-mediated arachidonic acid oxidation using [14C]AA as substrate after 3 hrs by GC/NICI/MS analysis | B | 5.64 | pIC50 | 2300 | nM | IC50 | ACS Med Chem Lett (2013) 4: 710-714 [PMID:24482730] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiparasitic activity against chloroquine-resistant Plasmodium falciparum K1 | F | 4.06 | pIC50 | 86700 | nM | IC50 | J Med Chem (2008) 51: 1260-1277 [PMID:18260613] |
| TRPV4 in Human [GtoPdb: 510] [UniProtKB: Q9HBA0] | ||||||||
| GtoPdb | - | - | 6.52 | pIC50 | 300 | nM | IC50 | Heliyon (2020) 6: e03301 [PMID:32051870] |
| COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| GtoPdb | - | - | 3.94 | pKi | 113600 | nM | Ki | FASEB J (2008) 22: 383-90 [PMID:17884974] |
| COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| GtoPdb | - | - | 4.59 | pKi | 25800 | nM | Ki | FASEB J (2008) 22: 383-90 [PMID:17884974] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
