ChEMBL ligand: CHEMBL118 (Celebra, Celebrex, Celecoxib, DFN-15, DFN15, Elyxyb, NSC-719627, NSC-758624, Onsenal, SC-58635)
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!
AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] There should be some charts here, you may need to enable JavaScript!
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] There should be some charts here, you may need to enable JavaScript!
Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] There should be some charts here, you may need to enable JavaScript!
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Human [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] There should be some charts here, you may need to enable JavaScript!
Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] There should be some charts here, you may need to enable JavaScript!
β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] There should be some charts here, you may need to enable JavaScript!
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Dog [ChEMBL: CHEMBL4133] [UniProtKB: Q8HZR1] Cyclooxygenase-1 in Bovine [ChEMBL: CHEMBL2860] [UniProtKB: O62664] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] COX-1 /Cyclooxygenase-1 in Mouse [ChEMBL: CHEMBL2649] [GtoPdb: 1375] [UniProtKB: P22437] COX-1 /Cyclooxygenase-1 in Rat [ChEMBL: CHEMBL4042] [GtoPdb: 1375] [UniProtKB: Q63921] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Dog [ChEMBL: CHEMBL4033] [UniProtKB: Q8SPQ9] Cyclooxygenase-2 in Bovine [ChEMBL: CHEMBL3331] [UniProtKB: O62698] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] COX-2 /Cyclooxygenase-2 in Mouse [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769] COX-2 /Cyclooxygenase-2 in Rat [ChEMBL: CHEMBL2977] [GtoPdb: 1376] [UniProtKB: P35355] There should be some charts here, you may need to enable JavaScript!
Cytochrome c oxidase subunit 1 in Sheep [ChEMBL: CHEMBL6011] [UniProtKB: O78749] There should be some charts here, you may need to enable JavaScript!
Cytochrome c oxidase subunit 2 in Human [ChEMBL: CHEMBL6174] [UniProtKB: P00403] Cytochrome c oxidase subunit 2 in Sheep [ChEMBL: CHEMBL1250404] [UniProtKB: O78750] There should be some charts here, you may need to enable JavaScript!
CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] There should be some charts here, you may need to enable JavaScript!
Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] There should be some charts here, you may need to enable JavaScript!
D1 receptor/Dopamine D1 receptor in Human [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Human [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959] There should be some charts here, you may need to enable JavaScript!
epoxide hydrolase 2/Epoxide hydratase in Human [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 5A/Phosphodiesterase 5A in Human [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074] There should be some charts here, you may need to enable JavaScript!
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis [ChEMBL: CHEMBL5767] [UniProtKB: P96878] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0] There should be some charts here, you may need to enable JavaScript!
mPGES1/Prostaglandin E synthase in Human [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684] There should be some charts here, you may need to enable JavaScript!
Quinolone resistance protein norA in S.aureus [ChEMBL: CHEMBL5114] [UniProtKB: P0A0J7] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Human [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!
TRPV1/Vanilloid receptor in Human [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] There should be some charts here, you may need to enable JavaScript!
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530]
ChEMBL	Inhibition of recombinant PDK1 using RPRAATF as substrate by scintillation counting	B	4.32	pIC50	48000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 1629-1632 [PMID:22266037]
ChEMBL	Inhibition of PDK1-mediated Akt activation in human PC3 cells after 2 hrs by Western blotting analysis	B	4.32	pIC50	48000	nM	IC50	Eur J Med Chem (2013) 65: 323-336 [PMID:23735281]
ChEMBL	In Vitro Kinase Assay: PDK-1 kinase activity This in vitro assay was performed using a PDK-1 kinase assay kit (Upstate, Lake Placid, N.Y.) according to the vendor's instructions. This cell-free assay is based on the ability of recombinant PDK-1, in the presence of DMSO vehicle or the test agent, to activate its downstream kinase serum- and glucocorticoid-regulated kinase (SGK.) which, in turn, phosphorylates the Akt/SGK-specific peptide substrate RPRAATF with [γ-32]-ATP. The [32P]-phosphorylated peptide substrate was then separated from the residual [γ-32P]-ATP using PS1 phosphocellulose paper and quantitated by a scintillation counter after three washes with 0.75% phosphoric acid.	B	4.32	pIC50	48000	nM	IC50	US-8741944-B2. Anti-infective agents against intracellular pathogens (2014)
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)	B	4.86	pKi	13917	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA)	B	4.61	pIC50	24622	nM	IC50	DrugMatrix in vitro pharmacology data
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.76	pKi	173	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	6.16	pKi	692	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine)	B	5.82	pIC50	1516	nM	IC50	DrugMatrix in vitro pharmacology data
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	B	7.47	pKi	34.2	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.47	pKi	34.2	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Inhibition of 15-LOX (unknown origin)	B	7.31	pIC50	49	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917]
ChEMBL	Inhibition of 5LOX in human whole blood assessed as inhibition of calcium ionophore A 23187-stimulated 5HETE production by HPLC analysis	F	5	pIC50	>10000	nM	IC50	J Med Chem (2004) 47: 6195-6206 [PMID:15566290]
ChEMBL	Inhibition of 5-LOX (unknown origin)	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2023) 80: 129101-129101 [PMID:36481449]
ChEMBL	Inhibition of 5-LOX (unknown origin) using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 10 mins	B	5.76	pIC50	1720	nM	IC50	Eur J Med Chem (2020) 189: 112066-112066 [PMID:31982653]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	6.14	pKi	732	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL	DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)	B	4.92	pKi	12093	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol)	B	4.79	pIC50	16124	nM	IC50	DrugMatrix in vitro pharmacology data
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.16	pKi	6.9	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay	B	6.15	pKi	713	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3588c pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.15	pKi	713	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	B	6	pKi	1010	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	B	6.85	pKi	140	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	6.16	pKi	690	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	B	4.41	pKi	38500	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	B	5.99	pKi	1017	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	5.99	pKi	1017	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	6.94	pKi	116	nM	Ki	Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	B	6.97	pKi	108	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay	B	7.35	pKi	45	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 after 15 mins by stopped-flow CO2 hydration assay	B	7.35	pKi	45	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	5.51	pKi	3056	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL	Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay	B	6.01	pKi	981	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory activity against cloned human CA1	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	4.3	pKi	50000	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human carbonic anhydrase 1-catalyzed CO2 hydration activity by stopped flow assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of human recombinant full length CA1 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	4.3	pKi	50000	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	J Med Chem (2012) 55: 10742-10748 [PMID:23181552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human recombinant CA-1 after 15 mins by stopped-flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCAI)	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	4.3	pKi	50000	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of recombinant human cytosolic carbonic anhydrase 1 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibitory activity against human carbonic anhydrase I was determined	B	4.3	pIC50	50000	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase I	F	4.3	pIC50	50000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	Inhibitory concentration against carbonic anhydrase I	B	5	pIC50	>10000	nM	IC50	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Inhibitory activity against human carbonic anhydrase II at 0.01 uM	B	4.68	pKi	21000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	6.38	pKi	421	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.11	pKi	76.8	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	7.68	pKi	21	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.68	pKi	21	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of human recombinant full length CA2 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.68	pKi	21	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2012) 55: 10742-10748 [PMID:23181552]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human recombinant CA-2 after 15 mins by stopped-flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCAII)	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Binding affinity to human recombinant CA2 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.68	pKi	21	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibition of cloned human carbonic anhydrase II	B	7.68	pKi	21	nM	Ki	J Med Chem (2005) 48: 5721-5727 [PMID:16134940]
ChEMBL	Inhibitory activity against cloned human CA2	B	7.68	pKi	21	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA))	B	6.74	pIC50	181	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibitory activity against human carbonic anhydrase II was determined	B	7.68	pIC50	21	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against human carbonic anhydrase II	F	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
ChEMBL	Inhibitory concentration against carbonic anhydrase II	B	7.68	pIC50	21	nM	IC50	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 3 after 15 mins by stopped-flow CO2 hydration assay	B	4.15	pKi	70000	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant full length CA3 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	5.13	pKi	7400	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibitory activity against human carbonic anhydrase IV (hCAIV)	B	6.06	pKi	880	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assay	B	6.06	pKi	880	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant full length CA4 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.06	pKi	880	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
ChEMBL	Inhibition of recombinant human membrane-associated carbonic anhydrase 4 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.54	pKi	290	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Binding affinity to human recombinant CA4 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	6.54	pKi	290	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)	B	6.54	pKi	290	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against CA4 isolated from bovine lung microsomes	B	6.54	pKi	290	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV was determined	B	6.54	pIC50	290	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory activity of compound against bovine carbonic anhydrase IV	F	6.54	pIC50	290	nM	IC50	Bioorg Med Chem Lett (2004) 14: 337-341 [PMID:14698154]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX at 0.09 uM	B	4.8	pKi	16000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of recombinant human tumor-associated carbonic anhydrase 9 assessed as inhibition of CO2 hydration preincubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.7	pKi	20	nM	Ki	Bioorg Med Chem (2017) 25: 2210-2217 [PMID:28256371]
ChEMBL	Inhibitory activity against cloned human CA9	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay	B	7.8	pKi	16	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.8	pKi	16	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant CA-9 after 15 mins by stopped-flow CO2 hydrase assay	B	7.8	pKi	16	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
ChEMBL	Inhibition of human recombinant CA9	B	7.8	pKi	16	nM	Ki	Eur J Med Chem (2020) 205: 112666-112666 [PMID:32795767]
ChEMBL	Inhibition of catalytic domain of human recombinant carbonic anhydrase IX	B	7.8	pKi	16	nM	Ki	J Med Chem (2005) 48: 5721-5727 [PMID:16134940]
ChEMBL	Binding affinity to human recombinant CA9 assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay	B	7.83	pKi	14.8	nM	Ki	Eur J Med Chem (2021) 209: 112923-112923 [PMID:33121862]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX was determined	B	7.8	pIC50	16	nM	IC50	J Med Chem (2004) 47: 550-557 [PMID:14736236]
ChEMBL	Inhibitory concentration against carbonic anhydrase IX	B	7.8	pIC50	16	nM	IC50	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5a after 15 mins by stopped-flow CO2 hydration assay	B	6.1	pKi	794	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant full length CA5A pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.1	pKi	794	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 5b after 15 mins by stopped-flow CO2 hydration assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant full length CA5B pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.03	pKi	93	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.03	pKi	94	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay	B	7.03	pKi	94	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant full length CA6 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.03	pKi	94	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay	B	5.66	pKi	2170	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant full length CA7 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	5.66	pKi	2170	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	5.66	pKi	2170	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	5.66	pKi	2170	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	5.66	pKi	2170	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human recombinant CA-7 after 15 mins by stopped-flow CO2 hydrase assay	B	5.66	pKi	2170	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
GtoPdb	-	-	7.74	pKi	18	nM	Ki	Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175]
ChEMBL	Inhibitory activity against cloned human CA12	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem Lett (2011) 21: 5892-5896 [PMID:21852133]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.74	pKi	18	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human recombinant CA-12 after 15 mins by stopped-flow CO2 hydrase assay	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem (2015) 23: 1828-1840 [PMID:25766630]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay	B	7.01	pKi	98	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant CA13 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	7.01	pKi	98	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay	B	6.16	pKi	689	nM	Ki	Bioorg Med Chem Lett (2010) 20: 4376-4381 [PMID:20605094]
ChEMBL	Inhibition of human recombinant CA14 catalytic domain pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	6.16	pKi	689	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibition of human COX1 expressed in sf9 cells	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2005) 68: 1514-1518 [PMID:16252917]
ChEMBL	Compound was tested for the inhibition of recombinant human Prostaglandin G/H synthase 1 (COX-1)	B	4	pIC50	<100000	nM	IC50	J Med Chem (2003) 46: 5484-5504 [PMID:14640557]
ChEMBL	Inhibition of human platelets COX1 after 2 mins	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2010) 45: 6027-6038 [PMID:20970223]
ChEMBL	Inhibition of human platelet COX1	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2008) 43: 456-463 [PMID:17532544]
ChEMBL	Inhibition of COX1 in human OVCAR-3 cells assessed as reduction in PGE2 level incubated for 30 mins by ELISA	B	4.09	pIC50	80900	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
ChEMBL	Inhibition of COX1 (unknown origin) fluorescence based analysis	B	4.26	pIC50	54550	nM	IC50	J Nat Prod (2023) 86: 2592-2619 [PMID:37856864]
ChEMBL	Inhibition of COX-1 (unknown origin)	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2022) 229: 114085-114085 [PMID:34998058]
ChEMBL	Inhibition of human COX1 using arachidonic acid assessed as production of PGF2alpha after 5 mins by ELISA	B	4.36	pIC50	43370	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3491-3498 [PMID:27349331]
ChEMBL	Inhibition of COX1 (unknown origin) assessed as reduction in PGE2 level using arachidonic acid as substrate after 5 mins in presence of heme by ELISA	B	4.44	pIC50	36440	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3653-3660 [PMID:28720504]
ChEMBL	Inhibition of human recombinant COX1 by ELISA	B	4.49	pIC50	32600	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1947-1951 [PMID:25866240]
ChEMBL	Inhibition of human COX1 using arachidonic acid as substrate incubated for 2 mins by ELISA method	B	4.56	pIC50	27830	nM	IC50	Eur J Med Chem (2020) 185: 111780-111780 [PMID:31655429]
ChEMBL	Inhibition of COX-1 (unknown origin) by chemiluminescence assay	B	4.56	pIC50	27500	nM	IC50	Eur J Med Chem (2013) 62: 222-231 [PMID:23353741]
ChEMBL	Inhibition of COX1 by chemiluminescent enzyme assay	B	4.56	pIC50	27500	nM	IC50	Bioorg Med Chem (2011) 19: 6827-6832 [PMID:22000948]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1	B	4.57	pIC50	27000	nM	IC50	J Med Chem (2002) 45: 1511-1517 [PMID:11906292]
ChEMBL	Inhibitory effect on Prostaglandin G/H synthase 1 activity was evaluated in human whole blood as TXB2 production	F	4.58	pIC50	26400	nM	IC50	J Med Chem (2002) 45: 1402-1411 [PMID:11906281]
ChEMBL	Inhibition of COX1 (unknown origin)	B	4.59	pIC50	25740	nM	IC50	Eur J Med Chem (2013) 70: 579-588 [PMID:24211633]
ChEMBL	Inhibition of COX1 (unknown origin)	B	4.6	pIC50	25390	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1017-1025 [PMID:28089698]
ChEMBL	Inhibition of COX1 (unknown origin) using arachidonic acid as substrate incubated for 10 mins by Ellman's reagent based COX-1/COX-2 ELISA assay	B	4.61	pIC50	24470	nM	IC50	Eur J Med Chem (2019) 169: 168-184 [PMID:30877972]
ChEMBL	Inhibition of COX1	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5634-5637 [PMID:17822894]
ChEMBL	Inhibition of COX1 in human whole blood assessed as effect on A-23187-stimulated TxB2 production	B	4.63	pIC50	23470	nM	IC50	Bioorg Med Chem (2008) 16: 2697-2706 [PMID:18063374]
ChEMBL	Colorimetric Assay: The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as specified by the manufacturer.	B	4.64	pIC50	23000	nM	IC50	US-9388139-B2. Derivatives of celeboxib, use thereof and preparation thereof (2016)
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1	B	4.64	pIC50	22900	nM	IC50	J Med Chem (2001) 44: 2921-2927 [PMID:11520200]
ChEMBL	Inhibitory concentration against Prostaglandin G/H synthase 1	B	4.64	pIC50	22900	nM	IC50	J Med Chem (2001) 44: 3039-3042 [PMID:11520213]
ChEMBL	In vitro inhibitory concentration of compound required to inhibit Prostaglandin G/H synthase 1 enzyme was determined	B	4.64	pIC50	22900	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2753-2756 [PMID:12217369]
ChEMBL	Inhibition of COX-1 (unknown origin)	B	4.69	pIC50	20400	nM	IC50	Eur J Med Chem (2014) 81: 204-217 [PMID:24836072]
ChEMBL	Inhibition of COX1 assessed as TBX2 production in human whole blood	F	4.7	pIC50	20030	nM	IC50	Bioorg Med Chem Lett (2006) 16: 4440-4443 [PMID:16814546]
ChEMBL	Inhibition of COX-1 (unknown origin) assessed as reduction in PGH2 formation using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	4.7	pIC50	19880	nM	IC50	Bioorg Med Chem Lett (2021) 33: 127743-127743 [PMID:33316405]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production by radioimmunoassay	B	4.8	pIC50	16000	nM	IC50	Bioorg Med Chem (2008) 16: 8072-8081 [PMID:18752957]
ChEMBL	Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate and measured by fluorometric assay	B	4.82	pIC50	15275	nM	IC50	Eur J Med Chem (2022) 241: 114597-114597 [PMID:35931005]
GtoPdb	-	-	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2017) 141: 306-321 [PMID:29031075]; J Med Chem (1997) 40: 1347-65 [PMID:9135032]
ChEMBL	Inhibition of COX1 (unknown origin) by solid phase ELISA method	B	4.82	pIC50	15030	nM	IC50	Bioorg Med Chem (2014) 22: 4109-4118 [PMID:24934992]
ChEMBL	In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 1	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2000) 43: 775-777 [PMID:10715145]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 1	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1171-1174 [PMID:10328307]
ChEMBL	In vitro inhibitory concentration required to block recombinant human prostaglandin G/H synthase 1 (COX-1)	B	4.82	pIC50	15000	nM	IC50	J Med Chem (1997) 40: 1347-1365 [PMID:9135032]
ChEMBL	Inhibition of human COX1	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 993-996 [PMID:21215625]
ChEMBL	Inhibition of COX1	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2012) 55: 2287-2300 [PMID:22263894]
ChEMBL	In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 1	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2000) 43: 775-777 [PMID:10715145]
ChEMBL	Inhibition of human COX1 using arachidonic acid as substrate assessed as PGE2 formation incubated for 10 mins prior to substrate addition measured after 10 mins by ELISA	B	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2014) 76: 494-505 [PMID:24602792]
ChEMBL	Inhibition of COX1 in human whole blood assessed as reduction in calcium ionophore-stimulated TXB2 production incubated for 1 hr by ELISA	B	4.83	pIC50	14800	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by ELISA method	B	4.83	pIC50	14700	nM	IC50	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 1	B	4.85	pIC50	14200	nM	IC50	J Med Chem (2000) 43: 214-223 [PMID:10649977]
ChEMBL	Inhibition of COX1	B	4.85	pIC50	14000	nM	IC50	Eur J Med Chem (2008) 43: 2792-2799 [PMID:18262309]
ChEMBL	Compound was tested for the inhibition of human Prostaglandin G/H synthase 1 (COX-1) in human whole blood	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2003) 46: 5484-5504 [PMID:14640557]
ChEMBL	Compound was evaluated for inhibition concentration of prostaglandin G/H synthase 1 in human blood	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2004) 47: 2180-2193 [PMID:15084117]
ChEMBL	In vitro inhibition of Prostaglandin G/H synthase 1 in human whole blood	B	4.85	pIC50	14000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6049-6052 [PMID:15546727]
ChEMBL	In vitro inhibitory concentration against Prostaglandin G/H synthase 1 (COX-1) in human whole blood	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2005) 48: 3930-3934 [PMID:15916445]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TxB2 production after 1 hr	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2007) 50: 1449-1457 [PMID:17335184]
ChEMBL	Inhibition of COX1 in human whole blood assessed as effect on A23187-induced thromboxane B2 production	B	4.85	pIC50	14000	nM	IC50	J Med Chem (2007) 50: 6367-6382 [PMID:17994684]
ChEMBL	Inhibition of COX1 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay	F	4.87	pIC50	13500	nM	IC50	J Med Chem (2004) 47: 6195-6206 [PMID:15566290]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of 12-hydroxyheptadecatrienoic acid production by HPLC method	B	4.88	pIC50	13100	nM	IC50	Bioorg Med Chem (2010) 18: 3910-3924 [PMID:20451397]
ChEMBL	Inhibition of COX1 in human whole blood assessed as thromboxane B2 production by RIA	B	4.9	pIC50	12500	nM	IC50	J Med Chem (2010) 53: 723-733 [PMID:19957931]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TXB2 production	B	4.9	pIC50	12500	nM	IC50	J Med Chem (2007) 50: 5403-5411 [PMID:17915854]
ChEMBL	Inhibition of COX-1 in human whole blood assessed as thromboxane B2 production by RIA	B	4.9	pIC50	12470	nM	IC50	Bioorg Med Chem (2014) 22: 772-786 [PMID:24373735]
ChEMBL	Inhibition of platelet COX1-mediated TXB2 production in LPS-induced human whole blood after 60 mins by radioimmunoassay	B	4.9	pIC50	12470	nM	IC50	J Med Chem (2011) 54: 7759-7771 [PMID:21992176]
ChEMBL	In vitro inhibitory activity against recombinant human Prostaglandin G/H synthase 1	B	4.97	pIC50	10700	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1639-1643 [PMID:12729631]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of lipopolysaccharide-induced TxB2 production after 30 min by enzyme immunoassay	B	4.99	pIC50	10194	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of COX-1 by chemiluminescent assay	B	5	pIC50	10000	nM	IC50	Bioorg Med Chem (2012) 20: 6648-6654 [PMID:23062711]
ChEMBL	Biochemical index for Prostaglandin G/H synthase 1 measured as, thromboxane 2 (TXB2) levels following blood coagulation	B	5.01	pIC50	9730	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1745-1748 [PMID:10937738]
ChEMBL	Inhibition of COX1 (unknown origin)	B	5.1	pIC50	8000	nM	IC50	J Med Chem (2021) 64: 17656-17689 [PMID:34905377]
ChEMBL	Inhibition of COX1 by enzyme immunoassay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem (2009) 17: 1146-1151 [PMID:19157881]
ChEMBL	Inhibition of human whole blood COX-1 assessed as production of TXB2 after 24 hrs by EIA	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem (2011) 19: 3299-3311 [PMID:21570308]
ChEMBL	Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassay	B	5.18	pIC50	6650	nM	IC50	Bioorg Med Chem (2013) 21: 2355-2362 [PMID:23473947]
ChEMBL	Inhibitory activity against Prostaglandin G/H synthase 1 in human whole blood	B	5.2	pIC50	6300	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2207-2212 [PMID:10465547]
ChEMBL	In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1	B	5.2	pIC50	6300	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1773-1778 [PMID:10406640]
ChEMBL	Inhibitory concentration was measured against Prostaglandin G/H synthase 1 in human whole blood	B	5.2	pIC50	6300	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1195-1198 [PMID:12643942]
ChEMBL	In vitro potency against human Prostaglandin G/H synthase 1 (hCOX-1) in the human whole blood assay.	B	5.2	pIC50	6300	nM	IC50	J Med Chem (1999) 42: 1274-1281 [PMID:10197970]
ChEMBL	In vitro inhibitory potency against human COX-1 (HWB COX-2) by whole blood assay	B	5.2	pIC50	6300	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3181-3186 [PMID:10576684]
ChEMBL	Inhibition of Prostaglandin G/H synthase 1 in U-937 cells from human histiocytic lymphoma	B	5.29	pIC50	5100	nM	IC50	J Med Chem (2001) 44: 350-361 [PMID:11462976]
ChEMBL	In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells	B	5.29	pIC50	5100	nM	IC50	J Med Chem (2003) 46: 3463-3475 [PMID:12877584]
ChEMBL	Inhibition of COX1 in human whole blood assessed as inhibition of calcium ionophore A-23187-stimulated platelet aggregation by measuring TXB2 production	B	5.59	pIC50	2600	nM	IC50	J Med Chem (2004) 47: 6749-6759 [PMID:15615524]
ChEMBL	Inhibition of COX1 in human whole blood assessed as TXB2 production by enzyme immunoassay	B	5.59	pIC50	2600	nM	IC50	J Med Chem (2009) 52: 5864-5871 [PMID:19791801]
ChEMBL	Inhibition of COX-1 in human whole blood assessed as thromboxane B2 level in serum after 5 mins by enzyme immunoassay	B	5.59	pIC50	2600	nM	IC50	Eur J Med Chem (2014) 74: 12-22 [PMID:24440378]
ChEMBL	Inhibition of arachidonic acid induced TXB2 generation in isolated human platelets (Prostaglandin G/H synthase 1 cell assay)	F	5.7	pIC50	2000	nM	IC50	J Med Chem (2002) 45: 1402-1411 [PMID:11906281]
ChEMBL	In vitro inhibition of cyclooxygenase-1 by inhibition of TXB2 generation with 1 uM arachidonic acid in human platelets	F	5.73	pIC50	1880	nM	IC50	Bioorg Med Chem Lett (2002) 12: 533-537 [PMID:11844666]
ChEMBL	Inhibition of human cyclooxygenase-1 expressed in COS cells	B	5.77	pIC50	1689	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5445-5448 [PMID:15454242]
ChEMBL	Inhibition of human COX1 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 treated 1 hr before arachidonic acid challenge by enzyme immunoassay	B	5.77	pIC50	1689	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of human COX1 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 hr before arachidonic acid challenge by enzyme immunoassay	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	6.14	pIC50	723	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human recombinant COX1 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition for 30 secs and measured after 1 hr by microplate reader based enzyme immunoassay	B	6.88	pIC50	131.97	nM	IC50	Eur J Med Chem (2019) 171: 332-342 [PMID:30928706]
ChEMBL	Inhibition of COX1 (unknown origin) using arachidonic acid as substrate pretreated for 10 mins followed by substrate addition measured after 2 mins by enzyme-immunoassay	B	6.9	pIC50	125	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2377-2383 [PMID:28427813]
ChEMBL	In vitro inhibitory potency against U-937 microsomal COX-1	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3181-3186 [PMID:10576684]
ChEMBL	Inhibition of COX-1 in U-937 (human lymphoma) cell microsomes.	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3187-3192 [PMID:10576685]
ChEMBL	In vitro potency against human Prostaglandin G/H synthase 1 in U937 microsomes.	B	7.3	pIC50	50	nM	IC50	J Med Chem (1999) 42: 1274-1281 [PMID:10197970]
ChEMBL	Inhibitory concentration was measured against Prostaglandin G/H synthase 1 in the sensitive U937 microsome assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1195-1198 [PMID:12643942]
ChEMBL	Inhibition of COX1 (unknown origin)	B	7.89	pIC50	13	nM	IC50	Bioorg Med Chem Lett (2023) 80: 129101-129101 [PMID:36481449]
Cyclooxygenase-1 in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4133] [UniProtKB: Q8HZR1]
ChEMBL	In vitro inhibitory activity against canine prostaglandin G/H synthase 1.	B	5.25	pIC50	5570	nM	IC50	Bioorg Med Chem Lett (2004) 14: 95-98 [PMID:14684306]
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL	Inhibition of Bos taurus (bovine) COX-1 by Chemoiluminescence assay	B	4.61	pIC50	24300	nM	IC50	Med Chem Res (2010) 19: 782-793
ChEMBL	Inhibition of bovine COX1 assessed as PGE2 formation preincubated for 10 mins by ELISA	B	4.67	pIC50	21610	nM	IC50	Eur J Med Chem (2011) 46: 5763-5768 [PMID:22019186]
ChEMBL	Inhibition of COX1 in calf endotheliocyte assessed as 6keto-PGF1alpha production pretreated for 20 mins followed by addition of 10 uM arachidonic acid as substrate for 20 mins by radioimmuno assay	B	5.09	pIC50	8200	nM	IC50	Eur J Med Chem (2016) 108: 89-103 [PMID:26638042]
ChEMBL	Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC	B	5.1	pIC50	8000	nM	IC50	Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798]
ChEMBL	Inhibition of bovine COX1 by enzyme immunoassay	B	5.11	pIC50	7700	nM	IC50	J Med Chem (2009) 52: 1525-1529 [PMID:19296694]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition by ELISA	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2016) 24: 3818-3828 [PMID:27344214]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid after 5 mins by colorimetric method	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2015) 23: 6807-6814 [PMID:26455657]
ChEMBL	Inhibition of ovine COX1 after 5 mins by enzyme immunoassay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2011) 46: 1648-1655 [PMID:21388719]
ChEMBL	Inhibition of recombinant ovine COX1	B	4	pIC50	>100000	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2008) 16: 3907-3916 [PMID:18272371]
ChEMBL	Inhibition of ovine COX1 after 2 mins by EIA	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2014) 80: 167-174 [PMID:24780593]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid as substrate assessed as production of PGH2-alpha preincubated for 5 mins followed by addition of substrate measured after 2 mins by EIA	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2016) 24: 2032-2042 [PMID:27025563]
ChEMBL	Inhibition of ovine COX1-mediated prostaglandin alpha production by enzyme immuno assay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2013) 23: 2601-2605 [PMID:23528298]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated with compound for 5 mins followed by substrate addition and measured after 2 mins by fluorescence spectrum analysis	B	4	pIC50	>100000	nM	IC50	J Nat Prod (2023) 86: 958-965 [PMID:36880830]
ChEMBL	Inhibition of ovine COX-1 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resorufin after 5 mins by fluorescence based assay	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem Lett (2015) 25: 3295-3300 [PMID:26081289]
ChEMBL	Inhibition of ovine COX1 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured after 2 mins by enzyme immunoassay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2015) 92: 115-123 [PMID:25549551]
ChEMBL	Inhibition of ovine COX1 preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 2 mins by enzyme immunoassay	B	4	pIC50	>100000	nM	IC50	Eur J Med Chem (2016) 115: 121-131 [PMID:26999325]
ChEMBL	Inhibition of ovine COX1 pre-incubated for 15 mins followed by addition of heme and fluorometric substrate and further incubated for 15 mins in presence of arachidonic acid by fluorescence based assay	B	4.09	pIC50	81700	nM	IC50	Bioorg Med Chem Lett (2015) 25: 2469-2472 [PMID:25980909]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid after 15 mins by fluorescence based assay	B	4.11	pIC50	78400	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4082-4084 [PMID:26316467]
ChEMBL	Inhibition of ovine COX1 using fluorometric substrate after 15 mins	B	4.11	pIC50	78400	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1986-1989 [PMID:25819096]
ChEMBL	Inhibition of sheep COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by UV-visible spectrophotometric method	B	4.14	pIC50	72520	nM	IC50	Eur J Med Chem (2020) 186: 111863-111863 [PMID:31740050]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGH2-dervied PGF2alpha production using arachidonic acid substrate by enzyme immunoassay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 87: 868-880 [PMID:24576797]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	4.3	pIC50	>50000	nM	IC50	Medchemcomm (2016) 7: 2309-2327
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGH2 production using arachidonic acid substrate by enzyme immunoassay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 86: 122-132 [PMID:25147154]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by enzyme immunoassay	B	4.3	pIC50	>50000	nM	IC50	Eur J Med Chem (2014) 76: 482-493 [PMID:24607877]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2012) 20: 3306-3316 [PMID:22516672]
ChEMBL	Inhibition of ovine COX1 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassay	B	4.3	pIC50	>50000	nM	IC50	Bioorg Med Chem (2011) 19: 3416-3424 [PMID:21570309]
ChEMBL	Inhibition of full-length ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry	B	4.32	pIC50	48000	nM	IC50	Bioorg Med Chem (2022) 57: 116633-116633 [PMID:35134642]
ChEMBL	Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassay	B	4.46	pIC50	34500	nM	IC50	Eur J Med Chem (2012) 47: 111-124 [PMID:22119153]
ChEMBL	In vitro inhibitory concentration against ovine Prostaglandin G/H synthase 1	B	4.48	pIC50	33100	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4911-4914 [PMID:15341950]
ChEMBL	Inhibitory activity against ovine COX1	B	4.48	pIC50	33100	nM	IC50	J Med Chem (2006) 49: 1668-1683 [PMID:16509583]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	4.48	pIC50	33100	nM	IC50	Bioorg Med Chem (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	4.48	pIC50	33100	nM	IC50	Bioorg Med Chem (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	4.48	pIC50	33100	nM	IC50	Bioorg Med Chem (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL	In vitro inhibition of ovine prostaglandin G/H synthase 1	B	4.48	pIC50	33100	nM	IC50	J Med Chem (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL	In vitro inhibitory concentration against ovine Cyclooxygenase-1	B	4.48	pIC50	33100	nM	IC50	Bioorg Med Chem Lett (2005) 15: 439-442 [PMID:15603969]
ChEMBL	Inhibition of ovine COX1 assessed as inhibition of PGF2a formation after 20 mins by Ellman's method	B	4.48	pIC50	33100	nM	IC50	J Med Chem (2010) 53: 3707-3717 [PMID:20387815]
ChEMBL	Inhibition of ovine Prostaglandin G/H synthase 1	B	4.48	pIC50	33100	nM	IC50	J Med Chem (2004) 47: 3972-3990 [PMID:15267236]
ChEMBL	In vitro inhibitory concentration against ovine Cyclooxygenase-1	B	4.48	pIC50	33100	nM	IC50	Bioorg Med Chem Lett (2005) 15: 439-442 [PMID:15603969]
ChEMBL	Inhibition of ovine COX1 by enzyme-immuno assay	B	4.48	pIC50	33100	nM	IC50	Eur J Med Chem (2009) 44: 3798-3804 [PMID:19457595]
ChEMBL	Inhibition of ovine COX1	B	4.49	pIC50	32000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 5324-5329 [PMID:25444084]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after 5 mins by EIA	B	4.52	pIC50	>30000	nM	IC50	Eur J Med Chem (2014) 80: 47-56 [PMID:24763362]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate assessed as production of PGF2alpha preincubated for 10 mins followed by substrate addition measured after 2 mins by EIA in presence of stannous chloride	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem (2013) 21: 4581-4590 [PMID:23769654]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate assessed as conversion of PGH2 to PGF2alpha after 10 mins by EIA	B	4.52	pIC50	>30000	nM	IC50	Bioorg Med Chem (2014) 22: 2080-2089 [PMID:24631365]
ChEMBL	Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay	B	4.52	pIC50	30000	nM	IC50	ACS Med Chem Lett (2014) 5: 983-988 [PMID:25221653]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate	B	4.56	pIC50	27250	nM	IC50	ACS Med Chem Lett (2014) 5: 512-516 [PMID:24900871]
ChEMBL	Inhibition of ovine COX1	B	4.57	pIC50	26610	nM	IC50	Bioorg Med Chem Lett (2006) 16: 4440-4443 [PMID:16814546]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by colorimetric based ELISA	B	4.6	pIC50	>25000	nM	IC50	Eur J Med Chem (2018) 158: 134-143 [PMID:30216848]
ChEMBL	Inhibition of ovine COX1 by chemiluminescent assay	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3162-3165 [PMID:19447036]
ChEMBL	Inhibition of ovine COX1 by chemiluminescence assay	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem (2009) 17: 5369-5373 [PMID:19596198]
ChEMBL	Inhibition of ovine COX1 by chemiluminescent enzyme assay	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem (2009) 17: 5312-5317 [PMID:19560931]
ChEMBL	Inhibition of ovine COX1 by enzyme chemiluminescent enzyme assay	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem (2010) 18: 1029-1033 [PMID:20061161]
ChEMBL	Inhibition of ovine COX1 by chemiluminescence assay	B	4.61	pIC50	24300	nM	IC50	Eur J Med Chem (2010) 45: 4013-4017 [PMID:20691338]
ChEMBL	Inhibition of Ovine COX-1 by chemiluminescent enzyme method	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem (2021) 32: 115960-115960 [PMID:33477020]
ChEMBL	Inhibition of ovine COX1 by chemiluminescent assay	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1336-1339 [PMID:18226898]
ChEMBL	Inhibition of Ovis aries (sheep) COX1 using arachidonic acid as substrate using cyclic naphthalene hydrazide by chemiluminescence assay	B	4.61	pIC50	24300	nM	IC50	Med Chem Res (2012) 21: 1869-1875
ChEMBL	Inhibition of Ovis aries (sheep) COX1 using arachidonic acid as substrate using cyclic naphthalene hydrazide by chemiluminescence assay	B	4.61	pIC50	24300	nM	IC50	Med Chem Res (2012) 21: 1803-1810
ChEMBL	Inhibition of Ovis aries (sheep) cyclooxygenase-1 using arachidonic acid as substrate by chemiluminescent assay	B	4.61	pIC50	24300	nM	IC50	Med Chem Res (2013) 22: 3881-3887
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate by chemiluminescence assay	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem (2014) 22: 865-873 [PMID:24361187]
ChEMBL	In vitro inhibitory activity against prostaglandin G/H synthase 1 from ovine	B	4.64	pIC50	23000	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1953-1956 [PMID:15050635]
ChEMBL	Inhibition of Ovis aries (sheep) COX-1 assessed as decrease in PGF2a production from PGH2 upon reduction with stannous chloride using arachidonic acid as substrate pre-incubated with enzyme for 5 min prior to substrate addition by enzyme immunoassay	B	4.64	pIC50	23000	nM	IC50	Med Chem Res (2013) 22: 2493-2504
ChEMBL	In vitro inhibition against ovine Prostaglandin G/H synthase 1	B	4.64	pIC50	22900	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2205-2209 [PMID:12798335]
ChEMBL	Inhibition of ram seminal vesicle COX-1 assessed as conversion of arachidonic acid to PGH2	B	4.64	pIC50	22900	nM	IC50	Bioorg Med Chem Lett (2014) 24: 317-324 [PMID:24295787]
ChEMBL	In vitro inhibitory activity against Prostaglandin G/H synthase 1 (COX-1)	B	4.64	pIC50	22900	nM	IC50	J Med Chem (2003) 46: 4872-4882 [PMID:14584938]
ChEMBL	Inhibition of ovine COX1 by measuring PGE2	B	4.72	pIC50	19030	nM	IC50	Bioorg Med Chem (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL	Inhibition of ovine COX-1 assessed as production of PGE2 using arachidonic acid as a substrate preincubated for 60 mins followed by substrate addition and measured after 2 mins by ELISA analysis	B	4.78	pIC50	16520	nM	IC50	Bioorg Med Chem (2021) 46: 116344-116344 [PMID:34438337]
ChEMBL	Inhibition of ovine COX-1 assessed as reduction in oxidation of TMPD using arachidonic acid as substrate preincubated for 5 mins followed by substrate and TMPD addition measured after 5 mins by colorimetric assay	B	4.79	pIC50	16200	nM	IC50	Bioorg Med Chem (2017) 25: 665-676 [PMID:27916468]
ChEMBL	In vitro inhibition against Prostaglandin G/H synthase 1 from ram seminal vesicles	B	4.81	pIC50	15330	nM	IC50	J Med Chem (2003) 46: 3975-3984 [PMID:12954051]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)	B	4.82	pIC50	15135.61	nM	IC50	J Med Chem (2002) 45: 4816-4827 [PMID:12383007]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	4.82	pIC50	15130	nM	IC50	Bioorg Med Chem (2016) 24: 5626-5632 [PMID:27658794]
ChEMBL	Inhibition of ovine COX-1 by EIA method	B	4.82	pIC50	15100	nM	IC50	Eur J Med Chem (2019) 183: 111693-111693 [PMID:31539778]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 77-82 [PMID:24332492]
ChEMBL	Inhibition of ovine COX-1 preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 2 mins by fluorescence analysis	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 5 mins by ELISA	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2018) 28: 952-957 [PMID:29426771]
ChEMBL	Inhibition of ovine COX-1 assessed as decrease in prostaglandin production using arachidonic acid as substrate incubated with enzyme for 10 mins prior to substrate challenge by enzyme immunoassay	B	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2014) 77: 185-192 [PMID:24631898]
ChEMBL	Inhibition of ovine COX1 by fluorescence assay	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem (2012) 20: 2221-2226 [PMID:22386983]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2016) 59: 3920-3934 [PMID:27019010]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6745-6749 [PMID:23010270]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate incubated for 10 mins followed by substrate addition and measured after 2 mins by EIA assay	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem (2020) 28: 115246-115246 [PMID:31843462]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2021) 64: 9550-9566 [PMID:34137625]
ChEMBL	Inhibition of ovine COX-1 assessed as PGF2alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis	B	4.82	pIC50	15000	nM	IC50	Eur J Med Chem (2015) 97: 104-123 [PMID:25956953]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assay	B	4.83	pIC50	14800	nM	IC50	Bioorg Med Chem (2017) 25: 5637-5651 [PMID:28916158]
ChEMBL	Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA method	B	4.83	pIC50	14800	nM	IC50	Eur J Med Chem (2019) 167: 562-582 [PMID:30818268]
ChEMBL	Inhibition of ovine COX -1 by colorimetric inhibitor screening assay kit method	B	4.83	pIC50	14800	nM	IC50	Eur J Med Chem (2019) 167: 161-186 [PMID:30771604]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGF2alpha production using arachidonic acid as substrate by colorimetric method	B	4.83	pIC50	14800	nM	IC50	Eur J Med Chem (2018) 144: 635-650 [PMID:29289887]
ChEMBL	Inhibition of ovine COX1 by colorimetric analysis	B	4.83	pIC50	14700	nM	IC50	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISA	B	4.85	pIC50	14000	nM	IC50	Eur J Med Chem (2017) 139: 936-946 [PMID:28881288]
ChEMBL	Inhibition of ovine COX1 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assay	B	4.85	pIC50	14000	nM	IC50	Bioorg Med Chem (2014) 22: 2855-2866 [PMID:24751552]
ChEMBL	Inhibition of ovine COX1	B	4.89	pIC50	13000	nM	IC50	Bioorg Med Chem (2008) 16: 276-283 [PMID:17937989]
ChEMBL	In vitro inhibitory activity against prostaglandin G/H synthase 1 from the microsomal fraction of ram seminal vesicles	B	4.97	pIC50	10700	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1683-1688 [PMID:15026050]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 1 from ram seminal vesicles	B	4.97	pIC50	10700	nM	IC50	Bioorg Med Chem Lett (2004) 14: 499-504 [PMID:14698190]
ChEMBL	Competitive inhibition of ovine COX1 by enzyme immunoassay	B	5	pIC50	10000	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2235-2238 [PMID:22341941]
ChEMBL	Inhibition of ovine COX-1 by fluorescence assay	B	5.03	pIC50	9400	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1823-1826 [PMID:21316237]
ChEMBL	Inhibition of sheep COX-1	B	5.06	pIC50	8770	nM	IC50	Eur J Med Chem (2023) 256: 115443-115443 [PMID:37182334]
ChEMBL	Inhibition of ovine COX-1 assessed as inhibition of transformation of AA to PGH2 by EIA	B	5.08	pIC50	8320	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL	Inhibition of ovine COX1 assessed as PGF2alpha level by EIA	B	5.09	pIC50	8100	nM	IC50	Bioorg Med Chem (2011) 19: 2074-2083 [PMID:21349729]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate by colorimetric enzyme immune assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4358-4369 [PMID:28844389]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of ovine COX1 by enzyme immunoassay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL	Inhibition of ovine COX1	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of ovine COX-1 by enzyme immuno assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.11	pIC50	7700	nM	IC50	Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of ovine COX-1 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay	B	5.12	pIC50	7600	nM	IC50	Eur J Med Chem (2016) 118: 250-258 [PMID:27131067]
ChEMBL	Inhibition of ovine COX-1	B	5.13	pIC50	7340	nM	IC50	RSC Med Chem (2022) 13: 1150-1196 [PMID:36325400]
ChEMBL	Inhibition of ovine COX1 assessed as PGH2 formation preincubated for 10 mins followed by addition of arachidonic acid as substrate measured after 2 mins by ELISA	B	5.15	pIC50	7000	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4757-4762 [PMID:27567369]
ChEMBL	Inhibition of ovine COX-1 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay	B	5.16	pIC50	6900	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5787-5791 [PMID:26546221]
ChEMBL	Inhibition of sheep COX1 by spectrophotometry	B	5.16	pIC50	6860	nM	IC50	J Med Chem (2010) 53: 6560-6571 [PMID:20804197]
ChEMBL	Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay	B	5.17	pIC50	6700	nM	IC50	Bioorg Med Chem (2017) 25: 4424-4432 [PMID:28669741]
ChEMBL	Inhibition of ovine COX1 by enzyme immuno assay	B	5.17	pIC50	6700	nM	IC50	Bioorg Med Chem Lett (2016) 26: 406-412 [PMID:26691756]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in Prostaglandin production by enzyme immunoassay	B	5.21	pIC50	6200	nM	IC50	Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	5.25	pIC50	5640	nM	IC50	Eur J Med Chem (2017) 127: 10-21 [PMID:28038322]
ChEMBL	Inhibition of ovine COX-1 by EIA method	B	5.26	pIC50	5460	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of ovine purified COX1 after 20 mins	B	5.4	pIC50	>4000	nM	IC50	ACS Med Chem Lett (2011) 2: 160-164 [PMID:21318094]
ChEMBL	Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL	Inhibition of ovine COX1 by fluorescence assay	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem (2013) 21: 4288-4295 [PMID:23706267]
ChEMBL	Inhibition of ovine COX1	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem (2007) 15: 1976-1982 [PMID:17258905]
ChEMBL	Inhibition of ovine COX-1 using arachidonic acid as substrate by fluorescence assay	B	7.04	pIC50	91	nM	IC50	Eur J Med Chem (2021) 224: 113682-113682 [PMID:34245948]
ChEMBL	Inhibition of COX1	B	8.43	pIC50	3.7	nM	IC50	Bioorg Med Chem Lett (2006) 16: 4483-4487 [PMID:16806914]
COX-1 /Cyclooxygenase-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2649] [GtoPdb: 1375] [UniProtKB: P22437]
ChEMBL	Inhibition of COX1-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIA	B	5.29	pIC50	5100	nM	IC50	J Med Chem (2010) 53: 723-733 [PMID:19957931]
ChEMBL	In vitro inhibitory activity against Prostaglandin G/H synthase 1 in murine J774 cells	B	5.29	pIC50	5100	nM	IC50	J Med Chem (2005) 48: 3428-3432 [PMID:15857149]
ChEMBL	Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate preincubated for 15 mins followed substrate addition and assessed as inhibition of PGE2 production after 30 mins by enzyme immuno-assay (EIA)	B	5.42	pIC50	3840	nM	IC50	Eur J Med Chem (2022) 241: 114615-114615 [PMID:35932568]
ChEMBL	Inhibition of COX-1-mediated PGE2 production in arachidonic acid-stimulated mouse J774 cells incubated for 15 mins prior to arachidonic acid-challenge by radioimmunoassay	B	5.42	pIC50	3840	nM	IC50	J Med Chem (2011) 54: 7759-7771 [PMID:21992176]
ChEMBL	Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of PGE2 production incubated for 15 mins prior to substrate addition measured after 30 mins by radioimmunoassay	B	5.42	pIC50	3840	nM	IC50	Bioorg Med Chem (2013) 21: 3695-3701 [PMID:23680444]
ChEMBL	Inhibition of COX1 in arachidonic acid-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassay	B	5.43	pIC50	3700	nM	IC50	Bioorg Med Chem (2008) 16: 8072-8081 [PMID:18752957]
ChEMBL	Inhibition of COX1 in mouse J774 cells assessed as arachidonic acid-induced PGE2 levels by radio immunoassay	B	5.43	pIC50	3700	nM	IC50	J Med Chem (2007) 50: 5403-5411 [PMID:17915854]
ChEMBL	Tested for inhibition against Prostaglandin G/H synthase 2 from mouse resident macrophages	B	9.15	pIC50	0.7	nM	IC50	J Med Chem (2000) 43: 4582-4593 [PMID:11101350]
COX-1 /Cyclooxygenase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4042] [GtoPdb: 1375] [UniProtKB: Q63921]
ChEMBL	Inhibition of rat seminal vesicle COX-1 using arachidonic acid as substrate assessed as reduction of PGG2 to PGH2 incubated for 1 min prior to substrate addition measured after 25 secs by chromogenic assay	B	4.82	pIC50	15000	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2251-2255 [PMID:24745964]
ChEMBL	In vitro inhibitory concentration against rat prostaglandin G/H synthase 1	B	4.85	pIC50	14200	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2687-2690 [PMID:11591502]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH based fluorometric analysis	B	9.33	pKi	0.47	nM	Ki	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	5.06	pIC50	8770	nM	IC50	Eur J Med Chem (2023) 256: 115443-115443 [PMID:37182334]
ChEMBL	Inhibitory effect on Prostaglandin G/H synthase 2 activity was evaluated in human whole blood as LPS-induced PGE-2 generation	F	5.44	pIC50	3600	nM	IC50	J Med Chem (2002) 45: 1402-1411 [PMID:11906281]
ChEMBL	Inhibition of COX-2 (unknown origin) incubated for 5 to 10 mins by fluorometric analysis	B	5.44	pIC50	3600	nM	IC50	Eur J Med Chem (2023) 249: 115138-115138 [PMID:36696764]
ChEMBL	Inhibition of PGHS2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassay	B	5.54	pIC50	2900	nM	IC50	Bioorg Med Chem (2009) 17: 74-84 [PMID:19059783]
ChEMBL	Inhibition of COX2 (unknown origin) by colorimetric method	B	5.58	pIC50	2660	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1952-1957 [PMID:24661847]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	5.64	pIC50	2270	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of human COX2 expressed in insect cells using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately	B	5.88	pIC50	1310	nM	IC50	J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
ChEMBL	Inhibition of recombinant human COX2 using arachidonic acid as substrate pretreated for 5 mins followed by substrate addition and measured after 2 mins by fluorescence based enzyme immunoassay	B	5.88	pIC50	1310	nM	IC50	Eur J Med Chem (2019) 180: 86-98 [PMID:31301566]
ChEMBL	Activity of COX2 in human heparinized blood assessed as inhibition of LPS-induced PGE2 production after 24 hrs	B	5.89	pIC50	1300	nM	IC50	J Med Chem (2007) 50: 1449-1457 [PMID:17335184]
ChEMBL	In vitro inhibitory concentration against Prostaglandin G/H synthase 2 (COX-2) in human whole blood	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2005) 48: 3930-3934 [PMID:15916445]
ChEMBL	Compound was tested for the inhibition of human Prostaglandin G/H synthase 2 (COX-2) in human whole blood	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2003) 46: 5484-5504 [PMID:14640557]
ChEMBL	Inhibition of COX2	B	5.92	pIC50	1200	nM	IC50	Eur J Med Chem (2008) 43: 2792-2799 [PMID:18262309]
ChEMBL	Compound was evaluated for inhibition concentration of prostaglandin G/H synthase 2 in human blood	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2004) 47: 2180-2193 [PMID:15084117]
ChEMBL	Inhibition of COX2 in human whole blood assessed as effect on LPS-induced thromboxane B2 production	B	5.92	pIC50	1200	nM	IC50	J Med Chem (2007) 50: 6367-6382 [PMID:17994684]
ChEMBL	In vitro inhibition of Prostaglandin G/H synthase 2 in human whole blood	B	5.92	pIC50	1200	nM	IC50	Bioorg Med Chem Lett (2004) 14: 6049-6052 [PMID:15546727]
ChEMBL	Inhibition of recombinant human COX2 using arachidonic acid as substrate by colorimetric enzyme immune assay	B	5.94	pIC50	1140	nM	IC50	Bioorg Med Chem Lett (2017) 27: 4358-4369 [PMID:28844389]
ChEMBL	Inhibition of human recombinant COX-2	B	5.95	pIC50	1110	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	5.95	pIC50	1110	nM	IC50	Eur J Med Chem (2023) 249: 115138-115138 [PMID:36696764]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 2	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2000) 43: 214-223 [PMID:10649977]
ChEMBL	Inhibition of human recombinant COX2 assessed as decrease in prostaglandin production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	5.97	pIC50	1070	nM	IC50	Medchemcomm (2019) 10: 1775-1788 [PMID:31803395]
ChEMBL	In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 2	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1773-1778 [PMID:10406640]
ChEMBL	Inhibitory potency against PGE-2 production in the human whole blood (HWB COX-2) assay	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3187-3192 [PMID:10576685]
ChEMBL	In vitro inhibitory potency against human COX-2 (HWB COX-2) by whole blood assay	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3181-3186 [PMID:10576684]
ChEMBL	In vitro potency against human Prostaglandin G/H synthase 2 in the human whole blood assay.	B	6	pIC50	1000	nM	IC50	J Med Chem (1999) 42: 1274-1281 [PMID:10197970]
ChEMBL	Inhibition of human COX2	B	6	pIC50	1000	nM	IC50	Eur J Med Chem (2008) 43: 1152-1159 [PMID:17976864]
ChEMBL	Inhibitory concentration was measured against Cyclooxygenase-2 in human whole blood	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1195-1198 [PMID:12643942]
ChEMBL	Inhibition of Prostaglandin G/H synthase 2 in human whole blood	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2207-2212 [PMID:10465547]
ChEMBL	Inhibition of human recombinant COX-2 preincubated for 2 mins prior to arachidonic acid addition by enzyme immuno assay	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5787-5791 [PMID:26546221]
ChEMBL	Inhibition of recombinant human COX2 using arachidonic acid as substrate assessed as decrease in PGF2 production preincubated for 15 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	6.06	pIC50	880	nM	IC50	Eur J Med Chem (2017) 127: 972-985 [PMID:27837994]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	6.06	pIC50	870	nM	IC50	Bioorg Med Chem Lett (2016) 26: 406-412 [PMID:26691756]
ChEMBL	Inhibition of COX-2 (unknown origin) by EIA kit method	B	6.06	pIC50	870	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassay	B	6.06	pIC50	870	nM	IC50	Bioorg Med Chem (2013) 21: 2355-2362 [PMID:23473947]
ChEMBL	Inhibition of human COX-2 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay	B	6.06	pIC50	870	nM	IC50	Bioorg Med Chem (2017) 25: 4424-4432 [PMID:28669741]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	6.06	pIC50	870	nM	IC50	Medchemcomm (2017) 8: 492-500 [PMID:30108767]
ChEMBL	Inhibition of COX2 (unknown origin) by EIA	B	6.08	pIC50	840	nM	IC50	Eur J Med Chem (2019) 180: 486-508 [PMID:31330449]
ChEMBL	Inhibition of recombinant human COX-2 by colorimetric enzyme immunoassay	B	6.08	pIC50	830	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of COX2 in LPS-stimulated human blood	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of 12-hydroxyheptadecatrienoic acid production by HPLC method	B	6.1	pIC50	800	nM	IC50	Bioorg Med Chem (2010) 18: 3910-3924 [PMID:20451397]
ChEMBL	Inhibition of recombinant human COX-2 using arachidonic acid as substrate preincubated with compound for 5 mins followed by substrate addition and measured after 2 mins by fluorescence spectrum analysis	B	6.1	pIC50	790	nM	IC50	J Nat Prod (2023) 86: 958-965 [PMID:36880830]
ChEMBL	Inhibition of COX-2 (unknown origin) at 20 uM	B	6.11	pIC50	780	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of human COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	6.11	pIC50	780	nM	IC50	Eur J Med Chem (2017) 127: 10-21 [PMID:28038322]
ChEMBL	Inhibition of human COX2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA	B	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2020) 189: 112066-112066 [PMID:31982653]
ChEMBL	Inhibition of COX2 (unknown origin)	B	6.19	pIC50	640	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1017-1025 [PMID:28089698]
ChEMBL	In vitro percent inhibition of Prostaglandin G/H synthase 2 (COX-2) in human whole blood was determined	B	6.22	pIC50	600	nM	IC50	J Med Chem (2003) 46: 3463-3475 [PMID:12877584]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassay	B	6.27	pIC50	540	nM	IC50	Bioorg Med Chem (2008) 16: 8072-8081 [PMID:18752957]
ChEMBL	Inhibition of COX-2 in human whole blood assessed as prostaglandin E2 production by RIA	B	6.27	pIC50	540	nM	IC50	Bioorg Med Chem (2014) 22: 772-786 [PMID:24373735]
ChEMBL	Inhibition of COX2-mediated PGE2 production in LPS-induced human whole blood after 60 mins by radioimmunoassay	B	6.27	pIC50	540	nM	IC50	J Med Chem (2011) 54: 7759-7771 [PMID:21992176]
ChEMBL	Inhibition of COX2 in LPS-induced monocyte assessed as PGE2 production in human whole blood	B	6.27	pIC50	540	nM	IC50	J Med Chem (2007) 50: 5403-5411 [PMID:17915854]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 production by RIA	B	6.27	pIC50	540	nM	IC50	J Med Chem (2010) 53: 723-733 [PMID:19957931]
ChEMBL	Biochemical index for Prostaglandin G/H synthase 2 measured as, PGE-2 levels in lipopolysaccharide (LPS)-challenged human whole blood	B	6.28	pIC50	530	nM	IC50	Bioorg Med Chem Lett (2000) 10: 1745-1748 [PMID:10937738]
ChEMBL	Colorimetric Assay: The activities of COX-1 and COX-2 were measured after the addition of arachidonic acid and incubation at 25° C. for 5 min by absorbance at 590 nm as specified by the manufacturer.	B	6.3	pIC50	500	nM	IC50	US-9388139-B2. Derivatives of celeboxib, use thereof and preparation thereof (2016)
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	B	6.32	pIC50	484	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of COX2 in human whole blood assessed as reduction in LPS stimulated PGE2 production incubated for 1 hr by ELISA	B	6.36	pIC50	440	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of COX2 (unknown origin) assessed as reduction in PGE2 level using arachidonic acid as substrate after 5 mins in presence of heme by ELISA	B	6.39	pIC50	410	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3653-3660 [PMID:28720504]
ChEMBL	Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry	B	6.4	pIC50	400	nM	IC50	Bioorg Med Chem (2022) 57: 116633-116633 [PMID:35134642]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	6.42	pIC50	380	nM	IC50	Eur J Med Chem (2021) 226: 113865-113865 [PMID:34655985]
ChEMBL	Inhibition of human COX2 using [14C]arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by TLC	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112]
ChEMBL	Inhibition of COX2 (unknown origin) using arachidonic acid as substrate pretreated for 10 mins followed by substrate addition and measured after 2 mins by ELISA	B	6.44	pIC50	360	nM	IC50	Bioorg Med Chem (2018) 26: 4264-4275 [PMID:30031652]
ChEMBL	Inhibition of COX2 in LPS-stimulated human whole blood assessed as PGE2 production by enzyme immunoassay	B	6.46	pIC50	350	nM	IC50	J Med Chem (2009) 52: 5864-5871 [PMID:19791801]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production	B	6.46	pIC50	350	nM	IC50	J Med Chem (2004) 47: 6749-6759 [PMID:15615524]
ChEMBL	Inhibition of COX-2 in human whole blood assessed as PGE2 level in plasma after 5 mins by enzyme immunoassay	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2014) 74: 12-22 [PMID:24440378]
ChEMBL	Inhibition of human recombinant COX-2 assessed as reduction in oxidation of TMPD using arachidonic acid as substrate preincubated for 5 mins followed by substrate and TMPD addition measured after 5 mins by colorimetric assay	B	6.47	pIC50	340	nM	IC50	Bioorg Med Chem (2017) 25: 665-676 [PMID:27916468]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of lipopolysaccharide-stimulated PGE2 production after 24 hrs by enzyme immunoassay	B	6.47	pIC50	336	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of COX2 assessed as LPS-stimulated PGE2 production in human whole blood leukocyte	F	6.48	pIC50	330	nM	IC50	Bioorg Med Chem Lett (2006) 16: 4440-4443 [PMID:16814546]
ChEMBL	Inhibition of human recombinant COX2 expressed in insect cell expression system using TMPD and arachidonic acid as substrate incubated for 1 min prior to substrate addition by spectrophotometry	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2013) 70: 579-588 [PMID:24211633]
ChEMBL	Inhibition of human COX2 using arachidonic acid assessed as production of PGF2alpha after 5 mins by ELISA	B	6.51	pIC50	310	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3491-3498 [PMID:27349331]
GtoPdb	-	-	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2017) 141: 306-321 [PMID:29031075]
ChEMBL	Inhibition of human recombinant COX2	B	6.52	pIC50	<300	nM	IC50	Eur J Med Chem (2008) 43: 456-463 [PMID:17532544]
ChEMBL	Inhibition of COX-2 (unknown origin) at 0.5 uM by colorimetric assay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of human COX-2 using [14C]-arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 45 mins by thin layer chromatographic method	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2017) 141: 306-321 [PMID:29031075]
ChEMBL	Inhibition of COX2 in human whole blood assessed as effect on LPS-stimulated PGE2 production	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2008) 16: 2697-2706 [PMID:18063374]
ChEMBL	Inhibition of human recombinant COX2 after 45 mins	B	6.52	pIC50	<300	nM	IC50	Eur J Med Chem (2010) 45: 6027-6038 [PMID:20970223]
ChEMBL	Inhibition of human recombinant COX2 using arachidonic acid as substrate	B	6.54	pIC50	290	nM	IC50	ACS Med Chem Lett (2014) 5: 512-516 [PMID:24900871]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2022) 229: 114085-114085 [PMID:34998058]
ChEMBL	Inhibition of human recombinant COX2 after 2 mins by EIA	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2014) 80: 167-174 [PMID:24780593]
ChEMBL	Inhibition of human recombinant COX2 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by enzyme immunoassay	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2014) 76: 482-493 [PMID:24607877]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	6.57	pIC50	270	nM	IC50	Eur J Med Chem (2014) 81: 204-217 [PMID:24836072]
ChEMBL	Inhibition of COX2 (unknown origin)	B	6.57	pIC50	270	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127376-127376 [PMID:32738961]
ChEMBL	Inhibition of recombinant N-terminal His6-tagged human COX-2 expressed in Baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 1 hr	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem (2018) 26: 5388-5396 [PMID:30293795]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2016) 108: 89-103 [PMID:26638042]
ChEMBL	Inhibition of COX2 (unknown origin) using arachidonic acid as substrate incubated for 10 mins by Ellman's reagent based COX-1/COX-2 ELISA assay	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2019) 169: 168-184 [PMID:30877972]
ChEMBL	Inhibition of human COX2 using arachidonic acid as substrate incubated for 2 mins by ELISA method	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2020) 185: 111780-111780 [PMID:31655429]
ChEMBL	Inhibition of COX-2 (unknown origin) assessed as reduction in PGH2 formation using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	6.62	pIC50	240	nM	IC50	Bioorg Med Chem Lett (2021) 33: 127743-127743 [PMID:33316405]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2	B	6.64	pIC50	230	nM	IC50	J Med Chem (2002) 45: 1511-1517 [PMID:11906292]
ChEMBL	Inhibition of COX2 (unknown origin)	B	6.66	pIC50	220	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1909-1912 [PMID:31160177]
ChEMBL	Inhibition of COX2 assessed as inhibition of PGE2 production using arachidonic acid as substrate after 10 mins by ELISA	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2012) 22: 793-796 [PMID:22217871]
ChEMBL	Inhibition of human whole blood COX-2 assessed as production of PGE2 after 24 hrs by EIA	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2011) 19: 3299-3311 [PMID:21570308]
ChEMBL	Inhibition of human COX2 assessed as fluorescence by microplate reader	B	6.8	pIC50	160	nM	IC50	Eur J Med Chem (2021) 222: 113564-113564 [PMID:34091208]
ChEMBL	Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 cells assessed as reduction in prostaglandin production by enzyme immunoassay	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2018) 26: 891-902 [PMID:29373271]
ChEMBL	Inhibition of COX2	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1612-1616 [PMID:21345672]
ChEMBL	Inhibition of COX2 in human whole blood assessed as inhibition of LPS-induced PGE2 synthesis up to 24 hrs by radioimmunoassay	B	6.85	pIC50	140	nM	IC50	Bioorg Med Chem Lett (2012) 22: 5031-5034 [PMID:22749420]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate measured after 10 mins by fluorometric based multimode microplate reader	B	6.88	pIC50	132	nM	IC50	Eur J Med Chem (2021) 209: 112918-112918 [PMID:33071054]
ChEMBL	Inhibition of recombinant human COX-2 assessed as reduction of prostaglandin-G2 to prostaglandin-H2 and oxidation of 10-acetyl-3,7-dihydroxyphenoxazine to resorufin after 5 mins by fluorescence based assay	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2015) 25: 3295-3300 [PMID:26081289]
ChEMBL	Inhibition of COX2 by chemiluminescent enzyme assay	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2011) 19: 6827-6832 [PMID:22000948]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem (2009) 17: 5182-5188 [PMID:19500994]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	6.92	pIC50	120	nM	IC50	J Med Chem (2009) 52: 1525-1529 [PMID:19296694]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2009) 19: 584-588 [PMID:19136259]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 5 to 10 mins by fluorometric analysis	B	6.92	pIC50	120	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of PGE-2 generation in LPS-stimulated human monocytes (Prostaglandin G/H synthase 2 cell assay)	F	6.92	pIC50	120	nM	IC50	J Med Chem (2002) 45: 1402-1411 [PMID:11906281]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immunoassay	B	6.92	pIC50	120	nM	IC50	Bioorg Med Chem Lett (2010) 20: 1324-1329 [PMID:20097072]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by spectrophotometer based analysis	B	6.94	pIC50	115	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	In vitro inhibition of PGE-2 generation by LPS-stimulated monocytes isolated from human blood.	F	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2002) 12: 533-537 [PMID:11844666]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 1 hr by absorbance based analysis	B	6.96	pIC50	110	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of human recombinant COX-2 assessed as PGF2alpha production by enzyme immunoassay	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2012) 47: 111-124 [PMID:22119153]
ChEMBL	Inhibition of COX-2 by chemiluminescent assay	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2012) 20: 6648-6654 [PMID:23062711]
ChEMBL	Inhibition of COX-2 (unknown origin) by chemiluminescence assay	B	7	pIC50	100	nM	IC50	Eur J Med Chem (2013) 62: 222-231 [PMID:23353741]
ChEMBL	Inhibition of COX2 human HCA7 cells	B	7.05	pIC50	90	nM	IC50	J Med Chem (2020) 63: 3817-3833 [PMID:31820982]
ChEMBL	Inhibition of recombinant human COX2	B	7.05	pIC50	90	nM	IC50	ACS Med Chem Lett (2021) 12: 798-804 [PMID:34055228]
ChEMBL	Inhibition of COX-2 in human Osteosarcoma cell incubated for 15 mins	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2023) 249: 115138-115138 [PMID:36696764]
ChEMBL	Inhibition of human COX2 expressed in sf9 cells	B	7.1	pIC50	80	nM	IC50	J Nat Prod (2005) 68: 1514-1518 [PMID:16252917]
ChEMBL	Inhibition of Prostaglandin G/H synthase 2 in 143.98.2 from human osteosarcoma cells	B	7.1	pIC50	80	nM	IC50	J Med Chem (2001) 44: 350-361 [PMID:11462976]
ChEMBL	In vitro inhibitory activity against human Prostaglandin G/H synthase 2 (COX-2) in 143982 cells	B	7.1	pIC50	79	nM	IC50	J Med Chem (2003) 46: 3463-3475 [PMID:12877584]
ChEMBL	Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substrate challenge for 2 mins by enzyme immunoassay	B	7.14	pIC50	72	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL	In vitro inhibition against human Prostaglandin G/H synthase 2	B	7.15	pIC50	70	nM	IC50	J Med Chem (2003) 46: 3975-3984 [PMID:12954051]
ChEMBL	Inhibition of human recombinant COX2	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2154-2159 [PMID:22361134]
ChEMBL	Inhibition of COX2 by enzyme immunoassay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2009) 17: 1146-1151 [PMID:19157881]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	7.15	pIC50	70	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of human recombinant COX-2 by enzyme immunoassay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2014) 22: 2529-2534 [PMID:24650702]
ChEMBL	Inhibition of human COX2 assessed as reduction in PGE2 production incubated for 2 mins using arachidonic acid substrate by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Medchemcomm (2017) 8: 492-500 [PMID:30108767]
ChEMBL	Inhibition of human COX2	B	7.15	pIC50	70	nM	IC50	J Med Chem (2020) 63: 3817-3833 [PMID:31820982]
ChEMBL	Inhibition of human recombinant COX2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2011) 21: 3951-3956 [PMID:21641217]
ChEMBL	Inhibition of human cyclooxygenase-2 expressed in COS cells	B	7.17	pIC50	68	nM	IC50	Bioorg Med Chem Lett (2004) 14: 5445-5448 [PMID:15454242]
ChEMBL	Inhibition of human COX2 expressed in african green monkey COS cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 hr before arachidonic acid challenge by enzyme immunoassay	B	7.17	pIC50	68	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of human recombinant COX2 by EIA	B	7.19	pIC50	65	nM	IC50	Bioorg Med Chem Lett (2010) 20: 5245-5250 [PMID:20655211]
ChEMBL	Inhibition of human COX2 by enzyme immunoassay	B	7.19	pIC50	65	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4544-4549 [PMID:20576432]
ChEMBL	Inhibition of human COX2 expressed in baculovirus-infected SF9 cells assessed as inhibition of arachidonic acid-stimulated PGE2 production treated 1 hr before arachidonic acid challenge by enzyme immunoassay	B	7.2	pIC50	63	nM	IC50	Bioorg Med Chem Lett (2009) 19: 4504-4508 [PMID:19520573]
ChEMBL	Inhibition of human COX2 by fluorescence based assay	B	7.22	pIC50	60	nM	IC50	Medchemcomm (2017) 8: 492-500 [PMID:30108767]
ChEMBL	Inhibition of COX2	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5634-5637 [PMID:17822894]
ChEMBL	Inhibition of human recombinant COX2 by enzymatic fluorescence assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2012) 20: 3410-3421 [PMID:22560838]
ChEMBL	Competitive inhibition of human recombinant COX2 by enzyme immunoassay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2235-2238 [PMID:22341941]
ChEMBL	Inhibition of COX-2 (unknown origin) by ELISA	B	7.24	pIC50	57	nM	IC50	Bioorg Med Chem Lett (2014) 24: 317-324 [PMID:24295787]
ChEMBL	Inhibition of COX2 (unknown origin)	B	7.24	pIC50	57	nM	IC50	Med Chem Res (2013) 22: 1529-1537
ChEMBL	Inhibition of COX2 (unknown origin) expressed in HEK293 TRex cells assessed as reduction in PGE2 production using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 1 hr in presence of 10% FBS by RapidFire High-Throughput Mass Spectrometry	B	7.24	pIC50	57	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibitory concentration against Prostaglandin G/H synthase 2	B	7.25	pIC50	56.7	nM	IC50	J Med Chem (2001) 44: 2921-2927 [PMID:11520200]
ChEMBL	In vitro inhibitory concentration of compound required to inhibit Prostaglandin G/H synthase 2 enzyme was determined	B	7.25	pIC50	56.7	nM	IC50	Bioorg Med Chem Lett (2002) 12: 2753-2756 [PMID:12217369]
ChEMBL	Inhibition of human recombinant COX-2 assessed as production of PGE2 using arachidonic acid as a substrate preincubated for 60 mins followed by substrate addition and measured after 2 mins by ELISA analysis	B	7.25	pIC50	56	nM	IC50	Bioorg Med Chem (2021) 46: 116344-116344 [PMID:34438337]
ChEMBL	Inhibition of recombinant human COX-2 by enzyme immunoassay	B	7.26	pIC50	55	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of COX-2 in human HNSCC 1483 cells using [14C] arachidonic acid as substrate preincubated for 30 mins before substrate addition measured after 30 mins	B	7.27	pIC50	54	nM	IC50	J Med Chem (2012) 55: 2287-2300 [PMID:22263894]
ChEMBL	Compound was tested for the inhibition of recombinant human Prostaglandin G/H synthase 2 (COX-2)	B	7.27	pIC50	54	nM	IC50	J Med Chem (2003) 46: 5484-5504 [PMID:14640557]
ChEMBL	Inhibition of human recombinant COX2 by ELISA	B	7.28	pIC50	52	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1947-1951 [PMID:25866240]
ChEMBL	Inhibitory concentration against Prostaglandin G/H synthase 2	B	7.29	pIC50	50.7	nM	IC50	J Med Chem (2001) 44: 3039-3042 [PMID:11520213]
ChEMBL	Inhibition of human recombinant COX2 by colorimetric analysis	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2020) 200: 112439-112439 [PMID:32485532]
ChEMBL	Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver esterase by fluorescence assay	B	7.3	pIC50	50	nM	IC50	ACS Med Chem Lett (2014) 5: 983-988 [PMID:25221653]
ChEMBL	Inhibition of human recombinant COX2 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2019) 167: 562-582 [PMID:30818268]
ChEMBL	Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate by colorimetric method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2018) 144: 635-650 [PMID:29289887]
ChEMBL	Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assay	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2017) 25: 5637-5651 [PMID:28916158]
ChEMBL	Inhibition of human recombinant COX-2 by EIA method	B	7.31	pIC50	49	nM	IC50	Eur J Med Chem (2019) 183: 111693-111693 [PMID:31539778]
ChEMBL	Inhibition of human recombinant COX-2	B	7.31	pIC50	49	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of human COX-2	B	7.32	pIC50	48	nM	IC50	Eur J Med Chem (2020) 200: 112438-112438 [PMID:32485533]
ChEMBL	Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA	B	7.35	pIC50	45	nM	IC50	Bioorg Med Chem (2020) 28: 115403-115403 [PMID:32127262]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by ELISA method	B	7.35	pIC50	45	nM	IC50	Eur J Med Chem (2023) 250: 115180-115180 [PMID:36796297]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by colorimetric analysis	B	7.35	pIC50	45	nM	IC50	Eur J Med Chem (2021) 219: 113457-113457 [PMID:33892270]
ChEMBL	Inhibition of human recombinant COX2 expressed in insect cells using arachidonic acid as substrate incubated for 1 min prior to substrate addition measured for 25 secs by TMPD-based chromogenic assay	B	7.38	pIC50	42	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6745-6749 [PMID:23010270]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after 2 mins by fluorescence based analysis	B	7.39	pIC50	40.95	nM	IC50	J Nat Prod (2023) 86: 2592-2619 [PMID:37856864]
ChEMBL	Inhibition of COX2 (unknown origin)	B	7.4	pIC50	40	nM	IC50	J Med Chem (2021) 64: 17656-17689 [PMID:34905377]
ChEMBL	Inhibition of human recombinant COX-2 expressed in insect cell system using arachidonic acid as substrate assessed as reduction of PGG2 to PGH2 incubated for 1 min prior to substrate addition measured after 25 secs by chromogenic assay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2014) 24: 2251-2255 [PMID:24745964]
ChEMBL	Inhibition of human recombinant COX2 using arachidonic acid as substrate incubated for 10 mins prior to substrate addition measured after 2 mins by spectrophotometry	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2014) 24: 77-82 [PMID:24332492]
ChEMBL	Inhibition of human recombinant COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate incubated with enzyme for 10 mins prior to substrate challenge by enzyme immunoassay	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2014) 77: 185-192 [PMID:24631898]
ChEMBL	Inhibition of COX2 (unknown origin) by solid phase ELISA method	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2014) 22: 4109-4118 [PMID:24934992]
ChEMBL	Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior to substrate addition by spectrophotometric analysis	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2015) 97: 104-123 [PMID:25956953]
ChEMBL	Inhibition of COX2	B	7.4	pIC50	40	nM	IC50	J Med Chem (2012) 55: 2287-2300 [PMID:22263894]
ChEMBL	Inhibition of COX2 (unknown origin)	B	7.4	pIC50	40	nM	IC50	Medchemcomm (2015) 6: 2081-2123
ChEMBL	Inhibition of COX-2 (unknown origin)	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL	Inhibition of recombinant human COX-2 preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 2 mins by fluorescence analysis	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1516-1520 [PMID:26898334]
ChEMBL	Inhibition of human recombinant COX2 assessed as reduction in PGH2-derived PGF2alpha using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	7.4	pIC50	40	nM	IC50	J Med Chem (2016) 59: 3920-3934 [PMID:27019010]
ChEMBL	Inhibition of human recombinant COX2 by fluorescence assay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2012) 20: 2221-2226 [PMID:22386983]
ChEMBL	Inhibition of human COX2	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2011) 21: 993-996 [PMID:21215625]
ChEMBL	Inhibition of human COX2 pre-incubated for 10 mins before arachidonic acid addition and measured after 2 mins by EIA method	B	7.4	pIC50	40	nM	IC50	J Med Chem (2018) 61: 7929-7941 [PMID:30095904]
ChEMBL	Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ELISA	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2019) 162: 1-17 [PMID:30396033]
ChEMBL	Inhibition of recombinant human COX-2 assessed as reduction in prostaglandin production preincubated for 10 mins followed by arachidonic acid addition and measured after 2 mins by EIA method	B	7.4	pIC50	40	nM	IC50	J Med Chem (2019) 62: 6363-6376 [PMID:31244108]
ChEMBL	Inhibition of human COX2 using arachidonic acid as substrate incubated for 10 mins followed by substrate addition and measured after 2 mins by EIA assay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2020) 28: 115246-115246 [PMID:31843462]
ChEMBL	In vitro inhibitory concentration required to block human recombinant prostaglandin G/H synthase 2 (COX-2)	B	7.4	pIC50	40	nM	IC50	J Med Chem (1997) 40: 1347-1365 [PMID:9135032]
ChEMBL	Inhibition of human COX-2 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA	B	7.4	pIC50	40	nM	IC50	J Med Chem (2021) 64: 9550-9566 [PMID:34137625]
ChEMBL	In vitro inhibitory activity against human Prostaglandin G/H synthase 2	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (1999) 9: 1171-1174 [PMID:10328307]
ChEMBL	Inhibition of human COX2 using arachidonic acid as substrate assessed as PGE2 formation incubated for 10 mins prior to substrate addition measured after 10 mins by ELISA	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2014) 76: 494-505 [PMID:24602792]
ChEMBL	Inhibitory concentration against human prostaglandin G/H synthase 2 at 25 degrees.	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2002) 12: 267-270 [PMID:11814774]
ChEMBL	In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2	B	7.4	pIC50	40	nM	IC50	J Med Chem (2000) 43: 775-777 [PMID:10715145]
ChEMBL	In Vitro activity of compound against human recombinant Prostaglandin G/H synthase 2	B	7.4	pIC50	40	nM	IC50	J Med Chem (2000) 43: 775-777 [PMID:10715145]
ChEMBL	Inhibition of COX-2 (unknown origin)	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2023) 256: 115443-115443 [PMID:37182334]
ChEMBL	Inhibition of recombinant human COX-2	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2023) 256: 115443-115443 [PMID:37182334]
ChEMBL	Inhibition of human Prostaglandin G/H synthase 2	B	7.4	pIC50	39.81	nM	IC50	J Med Chem (2001) 44: 3223-3230 [PMID:11563921]
ChEMBL	Inhibitory activity against human Prostaglandin G/H synthase 2 expressed in sf-9 cells infected with baculovirus	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2004) 14: 499-504 [PMID:14698190]
ChEMBL	In vitro inhibitory activity against recombinant human Prostaglandin G/H synthase 2	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1639-1643 [PMID:12729631]
ChEMBL	Inhibition of COX2 expressed in CHO cells assessed as inhibition of arachidonic acid-stimulated PGE2 production by enzyme immunoassay	F	7.44	pIC50	36	nM	IC50	J Med Chem (2004) 47: 6195-6206 [PMID:15566290]
ChEMBL	In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 expressed in sf-9 cells infected with baculovirus	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1683-1688 [PMID:15026050]
ChEMBL	Inhibition of human recombinant COX-2 assessed as reduction in PGF2alpha formation using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition for 30 secs and measured after 1 hr by microplate reader based enzyme immunoassay	B	7.45	pIC50	35.56	nM	IC50	Eur J Med Chem (2019) 171: 332-342 [PMID:30928706]
ChEMBL	Inhibition of human recombinant COX2 by measuring PGE2	B	7.46	pIC50	35	nM	IC50	Bioorg Med Chem (2007) 15: 6109-6118 [PMID:17604631]
ChEMBL	Inhibition of human recombinant COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by ADHP probe-based fluorescence assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2017) 27: 1721-1726 [PMID:28284805]
ChEMBL	Inhibition of COX2 by fluorescence assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2012) 22: 3567-3570 [PMID:22516282]
ChEMBL	Inhibition of human recombinant COX-2 by fluorescence assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2011) 21: 1823-1826 [PMID:21316237]
ChEMBL	Inhibition of human recombinant COX-2 assessed as reduction in peroxidase activity using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH based fluorometric analysis	B	7.55	pIC50	28	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of human recombinant COX2 by fluorescence assay	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2013) 21: 4288-4295 [PMID:23706267]
ChEMBL	Inhibition of recombinant human COX2 assessed as PGH2 formation preincubated for 10 mins followed by addition of arachidonic acid as substrate measured after 2 mins by ELISA	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4757-4762 [PMID:27567369]
ChEMBL	Inhibition of human recombinant COX2 using fluorometric substrate after 15 mins	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2015) 25: 1986-1989 [PMID:25819096]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid after 15 mins by fluorescence based assay	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4082-4084 [PMID:26316467]
ChEMBL	Inhibition of human COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 10 mins followed by substrate addition by ELISA	B	7.75	pIC50	17.79	nM	IC50	Eur J Med Chem (2019) 171: 25-37 [PMID:30904755]
ChEMBL	Inhibition of human recombinant COX2 pre-incubated for 15 mins followed by addition of heme and fluorometric substrate and further incubated for 15 mins in presence of arachidonic acid by fluorescence based assay	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem Lett (2015) 25: 2469-2472 [PMID:25980909]
ChEMBL	Inhibition of COX2 (unknown origin) fluorescence based analysis	B	7.82	pIC50	15	nM	IC50	J Nat Prod (2023) 86: 2592-2619 [PMID:37856864]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate and measured by fluorometric assay	B	7.91	pIC50	12.2	nM	IC50	Eur J Med Chem (2022) 241: 114597-114597 [PMID:35931005]
ChEMBL	Inhibition of human COX2 assessed as reduction in PGF2alpha level using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by ELISA	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem (2018) 26: 141-151 [PMID:29191502]
ChEMBL	Inhibition of human COX-2 using arachidonic acid as substrate incubated for 5 mins by fluorescence-based assay	B	7.95	pIC50	11.2	nM	IC50	Eur J Med Chem (2019) 180: 41-50 [PMID:31299586]
ChEMBL	Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate incubated for 1 min by absorbance based analysis	B	7.99	pIC50	10.25	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of human recombinant COX-2 after 2 mins by fluorescence assay	B	8	pIC50	10	nM	IC50	J Med Chem (2011) 54: 3037-3050 [PMID:21434686]
ChEMBL	Inhibition of recombinant human COX-2 preincubated for 15 mins followed by fluorometric substrate/heme addition for 15 mins subsequently incubated with arachidonic acid for 2 mins by fluorescence analysis	B	8.15	pIC50	7	nM	IC50	J Med Chem (2017) 60: 4135-4146 [PMID:28475316]
ChEMBL	Inhibitory concentration against COX-2; (valus obtained by Kato et al.)	B	8.17	pIC50	6.8	nM	IC50	J Med Chem (2005) 48: 6997-7004 [PMID:16250658]
ChEMBL	Inhibition of human recombinant COX-2 using arachidonic acid as substrate by fluorescence assay	B	8.22	pIC50	6	nM	IC50	Eur J Med Chem (2021) 224: 113682-113682 [PMID:34245948]
ChEMBL	Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree C	B	8.22	pIC50	6	nM	IC50	J Med Chem (2005) 48: 6997-7004 [PMID:16250658]
ChEMBL	Inhibition of COX2 (unknown origin) using arachidonic acid as substrate pretreated for 10 mins followed by substrate addition measured after 2 mins by enzyme-immunoassay	B	8.32	pIC50	4.8	nM	IC50	Bioorg Med Chem Lett (2017) 27: 2377-2383 [PMID:28427813]
ChEMBL	Inhibition of COX2	B	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem Lett (2006) 16: 4483-4487 [PMID:16806914]
ChEMBL	Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells.	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1195-1198 [PMID:12643942]
ChEMBL	In vitro potency against human Prostaglandin G/H synthase 2 in transfected CHO cells.	B	8.7	pIC50	2	nM	IC50	J Med Chem (1999) 42: 1274-1281 [PMID:10197970]
ChEMBL	In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3181-3186 [PMID:10576684]
ChEMBL	Inhibition of PGE-2 production in CHO cells expressing human COX-2.	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (1999) 9: 3187-3192 [PMID:10576685]
GtoPdb	-	-	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1195-8 [PMID:12643942]
ChEMBL	Inhibition of COX2	B	9.28	pIC50	0.52	nM	IC50	Eur J Med Chem (2008) 43: 1297-1303 [PMID:17714833]
ChEMBL	Inhibition of COX2	B	9.28	pIC50	0.52	nM	IC50	Eur J Med Chem (2008) 43: 1297-1303 [PMID:17714833]
Cyclooxygenase-2 in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4033] [UniProtKB: Q8SPQ9]
ChEMBL	In vitro inhibitory activity against canine prostaglandin G/H synthase 2.	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2004) 14: 95-98 [PMID:14684306]
Cyclooxygenase-2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3331] [UniProtKB: O62698]
ChEMBL	Inhibition of Bos taurus (bovine) COX-2 by Chemoiluminescence assay	B	7.22	pIC50	60	nM	IC50	Med Chem Res (2010) 19: 782-793
ChEMBL	In vitro inhibitory activity against prostaglandin G/H synthase 2 (COX-2)	B	7.24	pIC50	57	nM	IC50	J Med Chem (2003) 46: 4872-4882 [PMID:14584938]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibitory concentration against Prostaglandin G/H synthase 2 from sheep placenta at 100 uM	B	5.69	pIC50	2050	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1793-1797 [PMID:15780608]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	5.77	pIC50	1710	nM	IC50	Bioorg Med Chem (2008) 16: 3907-3916 [PMID:18272371]
ChEMBL	Inhibition of Ovine COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate pretreated for 15 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay	B	5.81	pIC50	1540	nM	IC50	Bioorg Med Chem Lett (2016) 26: 2893-2899 [PMID:27158139]
ChEMBL	Inhibition of ovine COX-2 assessed as reduction in PGF2-alpha formation using arachidonic acid as substrate by enzyme immunoassay	B	5.81	pIC50	1540	nM	IC50	Eur J Med Chem (2016) 118: 250-258 [PMID:27131067]
ChEMBL	Inhibition of ovine COX-2 assessed as appearance of oxidized TMPD level by EIA method	B	5.81	pIC50	1540	nM	IC50	Eur J Med Chem (2016) 123: 803-813 [PMID:27541263]
ChEMBL	Inhibition of ovine COX-2	B	5.95	pIC50	1110	nM	IC50	RSC Med Chem (2022) 13: 1150-1196 [PMID:36325400]
ChEMBL	Inhibition of ovine COX-2 colorimetric enzyme immunoassay	B	6.05	pIC50	890	nM	IC50	RSC Med Chem (2022) 13: 471-496 [PMID:35685617]
ChEMBL	Inhibition of ovine COX2	B	6.18	pIC50	660	nM	IC50	Bioorg Med Chem Lett (2017) 27: 3378-3381 [PMID:28610982]
ChEMBL	Inhibition of ovine COX-2 using arachidonic acid after 5 mins by colorimetric method	B	6.25	pIC50	560	nM	IC50	Bioorg Med Chem (2015) 23: 6807-6814 [PMID:26455657]
ChEMBL	Inhibition of ovine COX2 by colorimetric assay	B	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2019) 162: 435-447 [PMID:30469039]
ChEMBL	Inhibition of ovine COX2	B	6.36	pIC50	440	nM	IC50	Bioorg Med Chem Lett (2006) 16: 4440-4443 [PMID:16814546]
ChEMBL	Inhibition of ovine COX2 assessed as PGE2 formation preincubated for 10 mins by ELISA	B	6.44	pIC50	360	nM	IC50	Eur J Med Chem (2011) 46: 5763-5768 [PMID:22019186]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGF2alpha production using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 2 mins by colorimetric analysis	B	6.48	pIC50	330	nM	IC50	Eur J Med Chem (2016) 121: 410-421 [PMID:27318118]
ChEMBL	Inhibition of ovine COX2 assessed as PGF2alpha production from PGH2 after 5 mins by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2011) 19: 3416-3424 [PMID:21570309]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition by ELISA	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2016) 24: 3818-3828 [PMID:27344214]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGH2-dervied PGF2alpha production preincubated for 5 mins followed by addition of arachidonic acid as substrate measured after 2 mins by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2016) 115: 121-131 [PMID:26999325]
ChEMBL	Inhibition of ovine COX-2 using arachidonic acid as substrate assessed as production of PGH2-alpha preincubated for 5 mins followed by addition of substrate measured after 2 mins by EIA	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2016) 24: 2032-2042 [PMID:27025563]
ChEMBL	Inhibition of ovine COX2	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2014) 24: 5324-5329 [PMID:25444084]
ChEMBL	Inhibition of ovine COX2 after 5 mins by enzyme immunoassay	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2011) 46: 1648-1655 [PMID:21388719]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGH2-dervied PGF2alpha production using arachidonic acid substrate by enzyme immunoassay	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2014) 87: 868-880 [PMID:24576797]
ChEMBL	Inhibition of ovine COX2 by peroxidase activity-based colorimetric assay	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2014) 74: 606-618 [PMID:24531199]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	6.55	pIC50	280	nM	IC50	Bioorg Med Chem (2012) 20: 3306-3316 [PMID:22516672]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGH2 production using arachidonic acid substrate by enzyme immunoassay	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2014) 86: 122-132 [PMID:25147154]
ChEMBL	Inhibition of ovine COX2-mediated prostaglandin alpha production by enzyme immuno assay	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem Lett (2013) 23: 2601-2605 [PMID:23528298]
ChEMBL	Inhibition of ovine COX2 assessed as inhibition of PGF2alpha production from PGH2 preincubated for 5 mins before arachidonic acid addition measured after 2 mins by enzyme immunoassay	B	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2015) 92: 115-123 [PMID:25549551]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate assessed as conversion of PGH2 to PGF2alpha after 10 mins by EIA	B	6.66	pIC50	220	nM	IC50	Bioorg Med Chem (2014) 22: 2080-2089 [PMID:24631365]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by enzyme immunoassay	B	6.74	pIC50	180	nM	IC50	Medchemcomm (2016) 7: 2309-2327
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after 5 mins by EIA	B	6.82	pIC50	150	nM	IC50	Eur J Med Chem (2014) 80: 47-56 [PMID:24763362]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate assessed as production of PGF2alpha preincubated for 10 mins followed by substrate addition measured after 2 mins by EIA in presence of stannous chloride	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2013) 21: 4581-4590 [PMID:23769654]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGF2alpha formation incubated for 18 hrs by enzyme immunoassay	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2014) 24: 4638-4642 [PMID:25219899]
ChEMBL	Inhibition of ovine COX-2 assessed as inhibition of transformation of AA to PGH2 by EIA	B	6.95	pIC50	113	nM	IC50	Bioorg Med Chem Lett (2009) 19: 6922-6925 [PMID:19880317]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate incubated for 5 mins followed by substrate addition measured after 2 mins by colorimetric based ELISA	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2018) 158: 134-143 [PMID:30216848]
ChEMBL	Inhibition of sheep COX2 by spectrophotometry	B	7	pIC50	100	nM	IC50	J Med Chem (2010) 53: 6560-6571 [PMID:20804197]
ChEMBL	Inhibition of ovine COX2 by ELISA	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127173-127173 [PMID:32278513]
ChEMBL	Inhibition of ovine COX2 using arachidonic acid substrate by TMPD dye based colorimetry	B	7	pIC50	100	nM	IC50	Medchemcomm (2017) 8: 492-500 [PMID:30108767]
ChEMBL	Inhibitory activity against ovine COX2	B	7.15	pIC50	70	nM	IC50	J Med Chem (2006) 49: 1668-1683 [PMID:16509583]
ChEMBL	In vitro inhibition of ovine prostaglandin G/H synthase 2	B	7.15	pIC50	70	nM	IC50	J Med Chem (2004) 47: 6108-6111 [PMID:15537365]
ChEMBL	Inhibition of ovine COX2 assessed as inhibition of PGF2a formation after 20 mins by Ellman's method	B	7.15	pIC50	70	nM	IC50	J Med Chem (2010) 53: 3707-3717 [PMID:20387815]
ChEMBL	In vitro inhibitory concentration against ovine Cyclooxygenase-2	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2005) 15: 439-442 [PMID:15603969]
ChEMBL	In vitro inhibitory concentration against ovine Prostaglandin G/H synthase 2	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4911-4914 [PMID:15341950]
ChEMBL	Inhibition of ovine COX2 by enzyme-immuno assay	B	7.15	pIC50	70	nM	IC50	Eur J Med Chem (2009) 44: 3798-3804 [PMID:19457595]
ChEMBL	Inhibition of ovine Prostaglandin G/H synthase 2	B	7.15	pIC50	70	nM	IC50	J Med Chem (2004) 47: 3972-3990 [PMID:15267236]
ChEMBL	In vitro inhibitory concentration against ovine Cyclooxygenase-2	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2005) 15: 439-442 [PMID:15603969]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2008) 16: 9694-9698 [PMID:18930406]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2008) 18: 6138-6141 [PMID:18945614]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2008) 16: 3302-3308 [PMID:18096394]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2008) 16: 1948-1956 [PMID:18023187]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6074-6080 [PMID:21890358]
ChEMBL	Inhibition of ovine COX2 by enzyme immuno assay	B	7.15	pIC50	70	nM	IC50	Bioorg Med Chem (2007) 15: 6796-6801 [PMID:17764958]
ChEMBL	Inhibition of ovine COX2 by chemiluminescent assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2009) 19: 3162-3165 [PMID:19447036]
ChEMBL	Inhibition of ovine COX2 by chemiluminescence assay	B	7.22	pIC50	60	nM	IC50	Eur J Med Chem (2010) 45: 4013-4017 [PMID:20691338]
ChEMBL	Inhibition of Ovis aries (sheep) COX2 using arachidonic acid as substrate using cyclic naphthalene hydrazide by chemiluminescence assay	B	7.22	pIC50	60	nM	IC50	Med Chem Res (2012) 21: 1869-1875
ChEMBL	Inhibition of Ovis aries (sheep) COX2 using arachidonic acid as substrate using cyclic naphthalene hydrazide by chemiluminescence assay	B	7.22	pIC50	60	nM	IC50	Med Chem Res (2012) 21: 1803-1810
ChEMBL	Inhibition of Ovis aries (sheep) cyclooxygenase-2 using arachidonic acid as substrate by chemiluminescent assay	B	7.22	pIC50	60	nM	IC50	Med Chem Res (2013) 22: 3881-3887
ChEMBL	Inhibition of ovine COX2 using arachidonic acid as substrate by chemiluminescence assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2014) 22: 865-873 [PMID:24361187]
ChEMBL	Inhibition of ovine COX2 by enzyme chemiluminescent enzyme assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2010) 18: 1029-1033 [PMID:20061161]
ChEMBL	Inhibition of ovine COX2 by chemiluminescent enzyme assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2009) 17: 5312-5317 [PMID:19560931]
ChEMBL	Inhibition of ovine COX2 by chemiluminescence assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2009) 17: 5369-5373 [PMID:19596198]
ChEMBL	Inhibition of ovine COX2 by chemiluminescent assay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem Lett (2008) 18: 1336-1339 [PMID:18226898]
ChEMBL	Inhibition of Ovine COX-2 by chemiluminescent enzyme method	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2021) 32: 115960-115960 [PMID:33477020]
ChEMBL	Inhibition of Ovis aries (sheep) COX-2 assessed as decrease in PGF2a production from PGH2 upon reduction with stannous chloride using arachidonic acid as substrate pre-incubated with enzyme for 5 min prior to substrate addition by enzyme immunoassay	B	7.24	pIC50	57	nM	IC50	Med Chem Res (2013) 22: 2493-2504
ChEMBL	In vitro inhibitory activity against prostaglandin G/H synthase 2 from ovine	B	7.24	pIC50	57	nM	IC50	Bioorg Med Chem Lett (2004) 14: 1953-1956 [PMID:15050635]
ChEMBL	In vitro inhibition against ovine Prostaglandin G/H synthase 2	B	7.25	pIC50	56.7	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2205-2209 [PMID:12798335]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay	B	7.29	pIC50	50.7	nM	IC50	Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in oxidized TMPD using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetric assay	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2019) 171: 372-382 [PMID:30928709]
ChEMBL	Inhibition of ovine COX2 assessed as PGF2alpha level by EIA	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2011) 19: 2074-2083 [PMID:21349729]
ChEMBL	Inhibition of ovine COX -2 by colorimetric inhibitor screening assay kit method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2019) 167: 161-186 [PMID:30771604]
ChEMBL	Inhibition of sheep COX-2 by Cayman colorimetric analysis	B	7.4	pIC50	40	nM	IC50	RSC Med Chem (2022) 13: 522-567 [PMID:35694689]
ChEMBL	Inhibition of ovine COX2 peroxidase activity assessed as reduction of PGG2 to PGH2 by measuring oxidized TMPD level by colorimetric assay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2014) 22: 2855-2866 [PMID:24751552]
ChEMBL	Inhibition of ovine COX2 by enzyme immunoassay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2016) 24: 5626-5632 [PMID:27658794]
ChEMBL	Inhibition of ovine COX2	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem (2008) 16: 276-283 [PMID:17937989]
COX-2 /Cyclooxygenase-2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4321] [GtoPdb: 1376] [UniProtKB: Q05769]
ChEMBL	Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells at 10 uM by RIA	B	4.02	pIC50	95000	nM	IC50	J Med Chem (2010) 53: 723-733 [PMID:19957931]
ChEMBL	Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells at 1 uM by RIA	B	4.1	pIC50	80000	nM	IC50	J Med Chem (2010) 53: 723-733 [PMID:19957931]
ChEMBL	Inhibition of mouse COX2	B	4.6	pIC50	>25000	nM	IC50	Bioorg Med Chem (2007) 15: 1976-1982 [PMID:17258905]
ChEMBL	Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production	B	6.92	pIC50	120	nM	IC50	Eur J Med Chem (2013) 62: 222-231 [PMID:23353741]
ChEMBL	Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIA	B	7.1	pIC50	79	nM	IC50	J Med Chem (2010) 53: 723-733 [PMID:19957931]
ChEMBL	In vitro inhibitory activity against Prostaglandin G/H synthase 2 in murine J774 cells	B	7.1	pIC50	79	nM	IC50	J Med Chem (2005) 48: 3428-3432 [PMID:15857149]
ChEMBL	Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production and measured after 24 hrs by enzyme immuno-assay (EIA)	B	7.21	pIC50	61	nM	IC50	Eur J Med Chem (2022) 241: 114615-114615 [PMID:35932568]
ChEMBL	Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassay	B	7.21	pIC50	61	nM	IC50	J Med Chem (2011) 54: 7759-7771 [PMID:21992176]
ChEMBL	Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassay	B	7.21	pIC50	61	nM	IC50	Bioorg Med Chem (2013) 21: 3695-3701 [PMID:23680444]
ChEMBL	Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassay	B	7.22	pIC50	60	nM	IC50	J Med Chem (2007) 50: 5403-5411 [PMID:17915854]
ChEMBL	Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassay	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2008) 16: 8072-8081 [PMID:18752957]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)	B	7.4	pIC50	39.81	nM	IC50	J Med Chem (2002) 45: 4816-4827 [PMID:12383007]
ChEMBL	Inhibition of mouse purified COX2 after 20 mins	B	7.52	pIC50	30	nM	IC50	ACS Med Chem Lett (2011) 2: 160-164 [PMID:21318094]
ChEMBL	Tested for inhibition against Prostaglandin G/H synthase 1 from mouse resident macrophages	B	8.03	pIC50	9.3	nM	IC50	J Med Chem (2000) 43: 4582-4593 [PMID:11101350]
ChEMBL	Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay	B	8.06	pIC50	8.7	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1958-1962 [PMID:24656662]
ChEMBL	In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring reduction in polyp area and relevant plasma exposures	F	8.49	pIC50	3.2	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring reduction in polyp area and relevant ileum exposures	F	8.49	pIC50	3.2	nM	IC50	J Med Chem (2021) 64: 11570-11596 [PMID:34279934]
ChEMBL	Inhibition of LPS-induced COX2 activity in C57BL/6J mouse peritoneal macrophages by RIA	B	9.29	pIC50	0.51	nM	IC50	J Nat Prod (2006) 69: 1591-1595 [PMID:17125227]
COX-2 /Cyclooxygenase-2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2977] [GtoPdb: 1376] [UniProtKB: P35355]
ChEMBL	In vitro inhibitory concentration against rat Prostaglandin G/H synthase 2	B	5.96	pIC50	1100	nM	IC50	Bioorg Med Chem Lett (2001) 11: 2687-2690 [PMID:11591502]
ChEMBL	Inhibition of COX2 in rat abdominal macrophages assessed as PGE2 production pretreated for 30 mins followed by addition of 10 uM arachidonic acid as substrate for 20 mins by EIA	B	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2016) 108: 89-103 [PMID:26638042]
ChEMBL	Inhibition of COX-2 in rat peritoneal macrophages assessed as reduction in PGE2 production using radiolabelled-arachidonic acid as substrate pretreated for 30 mins followed by substrate addition measured after 30 mins	B	7.15	pIC50	71	nM	IC50	Bioorg Med Chem (2017) 25: 4887-4893 [PMID:28757100]
Cytochrome c oxidase subunit 1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6011] [UniProtKB: O78749]
ChEMBL	Inhibition of ovine COX1 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISA	B	4.56	pIC50	27250	nM	IC50	Eur J Med Chem (2019) 182: 111601-111601 [PMID:31445233]
ChEMBL	Inhibition of sheep COX1	B	4.61	pIC50	24300	nM	IC50	Bioorg Med Chem (2010) 18: 5855-5860 [PMID:20650641]
ChEMBL	Inhibition of ovine COX1 preincubated for 5 mins followed by arachidonic acid addition and measured after 2 mins by colorimetric method	B	5.19	pIC50	6500	nM	IC50	Bioorg Med Chem (2019) 27: 3979-3997 [PMID:31401008]
Cytochrome c oxidase subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6174] [UniProtKB: P00403]
ChEMBL	Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISA	B	6.27	pIC50	540	nM	IC50	Eur J Med Chem (2017) 139: 936-946 [PMID:28881288]
ChEMBL	Inhibition of recombinant human COX2 assessed as reduction in PGF2alpha incubated for 2 mins using arachidonic acid as substrate by ELISA	B	6.53	pIC50	293	nM	IC50	Eur J Med Chem (2019) 182: 111601-111601 [PMID:31445233]
ChEMBL	Inhibition of recombinant human COX2 expressed in baculovirus infected Sf21 cells using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by UV-visible spectrophotometric method	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2020) 186: 111863-111863 [PMID:31740050]
Cytochrome c oxidase subunit 2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1250404] [UniProtKB: O78750]
ChEMBL	Inhibition of ovine COX-2 by colorimetric inhibitor screening assay	B	6.8	pIC50	160	nM	IC50	Eur J Med Chem (2021) 221: 113493-113493 [PMID:34029774]
ChEMBL	Inhibition of ovine COX-2 using arachidonic acid as substrate measured after 2 mins by colorimetric enzyme immune assay	B	7.05	pIC50	90	nM	IC50	Eur J Med Chem (2021) 221: 113493-113493 [PMID:34029774]
ChEMBL	Inhibition of sheep COX2	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2010) 18: 5855-5860 [PMID:20650641]
ChEMBL	Inhibition of ovine COX-2 colorimetric enzyme immunoassay	B	7.37	pIC50	42.6	nM	IC50	Eur J Med Chem (2021) 221: 113493-113493 [PMID:34029774]
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL	DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	6	pIC50	1000	nM	IC50	DrugMatrix in vitro pharmacology data
Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
ChEMBL	Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	6.58	pKi	265	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728]
ChEMBL	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	B	4.85	pKi	13997	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	B	4.55	pIC50	27994	nM	IC50	DrugMatrix in vitro pharmacology data
DAT/Dopamine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL238] [GtoPdb: 927] [UniProtKB: Q01959]
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	5.71	pKi	1931	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55)	B	5.61	pIC50	2431	nM	IC50	DrugMatrix in vitro pharmacology data
epoxide hydrolase 2/Epoxide hydratase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913]
ChEMBL	Inhibition of human recombinant soluble epoxide hydrolase after 10 mins by fluorescent-based assay	B	6	pIC50	>1000	nM	IC50	J Med Chem (2011) 54: 3037-3050 [PMID:21434686]
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of full length recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay	B	5.93	pIC50	1185	nM	IC50	Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 cells using Boc-Lys-(Ac)-AMC as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins by fluorescence assay	B	6.19	pIC50	643	nM	IC50	Bioorg Med Chem (2018) 26: 1418-1425 [PMID:29500130]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibitory concentration against p38 alpha MAP kinase calculated by CoMFA model; FlexX score=-12.4 kcal/mol	B	6.09	pIC50	810	nM	IC50	Bioorg Med Chem Lett (2005) 15: 3506-3509 [PMID:15990304]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	5.14	pKi	7247	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	5.14	pIC50	7308	nM	IC50	DrugMatrix in vitro pharmacology data
phosphodiesterase 5A/Phosphodiesterase 5A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1827] [GtoPdb: 1304] [UniProtKB: O76074]
ChEMBL	Inhibition of recombinant 6His-tagged PDE5A1 catalytic domain (unknown origin) expressed in Escherichia coli using TAMRA-cGMP or FAM-cAMP as substrate incubated for 1.5 hrs by IMAP-FP assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2021) 64: 4462-4477 [PMID:33793216]
ChEMBL	Inhibition of recombinant full length GST-tagged PDE5A1 (unknown origin) expressed in baculovirus infected Sf9 insect cells using TAMRA-cGMP as substrate incubated for 1.5 hrs by IMAP-FP assay	B	4.43	pIC50	37000	nM	IC50	J Med Chem (2021) 64: 4462-4477 [PMID:33793216]
ChEMBL	Fluorescence Polarization Assay: PDE activity was measured using the IMAP fluorescence polarization assay (Molecular Devices) in which binding of hydrolyzed cyclic nucleotide substrate to immobilized metal coordination complexes increases fluorescence polarization (FP). Tetramethylrhodamine (TAMRA)-cGMP and fluorescein-cAMP were used as substrates, each at final concentration of 50 nmol/L. The PDE assay was done according to the manufacturer's specifications using either whole cell lysates or recombinant enzymes. FP was measured at excitation, emission wavelengths of either 530,590 nm for TAMRA-cGMP or 485,530 nm for fluorescein-cAMP using a Synergy4 (Biotek) microplate reader.	B	4.44	pIC50	36000	nM	IC50	US-9388139-B2. Derivatives of celeboxib, use thereof and preparation thereof (2016)
PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	5.11	pKi	7760	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	5.63	pKi	2362	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	4.74	pIC50	18109	nM	IC50	DrugMatrix in vitro pharmacology data
mPGES1/Prostaglandin E synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5658] [GtoPdb: 1377] [UniProtKB: O14684]
ChEMBL	Inhibition of mPGES1 (unknown origin) by enzymatic assay	B	6.27	pIC50	540	nM	IC50	J Med Chem (2016) 59: 194-205 [PMID:26653180]
ChEMBL	Inhibition of mPGES-1 in human whole blood assessed as reduction in LPS-induced PGE2 production preincubated for 30 mins followed by LPS stimulation for 20 to 24 hrs by LC/MS/MS analysis	B	6.27	pIC50	540	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4824-4828 [PMID:27554445]
ChEMBL	Inhibition of human microsomal PGES1 expressed in 293E cells by LC/MS/MS analysis	B	6.37	pIC50	425	nM	IC50	J Med Chem (2016) 59: 194-205 [PMID:26653180]
Quinolone resistance protein norA in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5114] [UniProtKB: P0A0J7]
ChEMBL	Inhibition of norA-mediated EtBr efflux in Staphylococcus aureus SA1199B overexpressing norA and expressing A116E GrlA mutation by fluorometry	B	4.4	pIC50	>40000	nM	IC50	J Med Chem (2012) 55: 3568-3572 [PMID:22432682]
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645]
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.48	pKi	3334	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine)	B	5.2	pIC50	6276	nM	IC50	DrugMatrix in vitro pharmacology data
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	B	4.99	pKi	10350	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 pre-incubated for 15 mins by stopped-flow CO2 hydration method	B	4.99	pKi	10350	nM	Ki	J Med Chem (2012) 55: 9619-9629 [PMID:23067387]
TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1]
ChEMBL	Inhibition of TRPV1 (unknown origin)	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2023) 80: 129101-129101 [PMID:36481449]
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505]
ChEMBL	Inhibition of Cav1.2 calcium current measured using whole Cell patch clamp in guinea pig ventricular myocytes	F	4.97	pIC50	10600	nM	IC50	IC50 data for the L-type calcium channel extracted from a set of literature articles

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]