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Chitinases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Chitinase 1 (CHIT1) and acidic mammalian chitinase (CHIA; AMCase) are the enzymatically active chitinases that are part of a key pathway in tissue remodeling, and which have been implicated in the pathology of chronic fibrotic lung diseases. Small molecule chitinase inhibitors are being investigated for anti-fibrotic efficacy in idiopathic pulmonary fibrosis (IPF) and offer potential for other diseases with a fibrotic component.

Enzymes

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AMCase (chitinase acidic) Show summary » More detailed page go icon to follow link

chitinase 1 Show summary » More detailed page go icon to follow link

References

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How to cite this family page

Database page citation:

Chitinases. Accessed on 29/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=981.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.