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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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Isocitrate dehydrogenase (IDH) enzymes are crucial components of the central cellular metabolic pathway, the Krebs cycle. The enzymes catalyze the oxidative decarboxylation of isocitrate to produce α-ketoglutarate and carbon dioxide.
isocitrate dehydrogenase (NADP(+)) 1 / IDH1 C Show summary » More detailed page |
isocitrate dehydrogenase (NADP(+)) 2 / IDH2 C Show summary » More detailed page |
Database page citation:
1.1.1.42 Isocitrate dehydrogenases. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=922.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.