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This family contains proteins that have 'reader' domains that recognise specific post-translational modifications on histones. Readers are involved in regulation of transcription, and can have repressive or activating functions.
Database page citation:
DNA and RNA reader proteins. Accessed on 29/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=901.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Cidlowski JA, Davenport AP, Fabbro D, Spedding M, Striessnig J, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets. Br J Pharmacol. 182: S1-S23.