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RZ family C

Formerly known as: A family of RGS proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The RZ family of RGS proteins is less well characterized than the other families. It consists of, RGS17 (also known as RGSZ2), RGS19 (also known as GAIP) and RGS20 (with several splice variants including RGSZ1 and Ret-RGS). All members contain an N-terminal cysteine string motif [3] which is a site of palmitoylation and could serve functions in membrane targeting, protein stability or aid protein-protein interactions [1,3]. However, the function in the case of RZ family RGS proteins is not yet fully understood. Members of the RZ family of RGS proteins are the only RGS proteins that have selective GAP activity for Gαz, a function that resulted in the name of the family [2,4-6]. However, the members of the RZ family are able to also GAP Gαi/o members with varying selectivity.


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RGS17 (regulator of G-protein signaling 17) C Show summary » More detailed page go icon to follow link

RGS19 (regulator of G-protein signaling 19) C Show summary » More detailed page go icon to follow link

RGS20 (regulator of G-protein signaling 20) C Show summary » More detailed page go icon to follow link


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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Buneman OP, Faccenda E, Harding SD, Spedding M, Cidlowski JA, Fabbro D, Davenport AP, Striessnig J, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets. Br J Pharmacol. 180 Suppl 2:S1-22.