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Poly ADP-ribosylating PARPs C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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This subfamily of four enzymes (the PARylating PARPs) catalyse the addition of poly-ADP-ribose chains as post-translational protein modifications . The best characterised members are the nuclear enzymes PARP1, PARP2 and the tankyrases (TNKSs). PARPs 1 and 2 appear to function by binding to single strand breaks in DNA, allowing the recruitment of repair enzymes by the synthesis of NAD-derived ADP-ribose polymers, that are subsequently degraded by a glycohydrolase (PARG, Q86W56). The most well defined function of the tankyrases (TNKSs) is their regulatory action on Wnt/β-catenin signalling [3]. PARPs 1 and 2 are targets of PARP inhibitor class anti-cancer drugs which are designed to disrupt the DNA damage response pathways to induce cancer cell death.

Enzymes

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PARP1 (poly(ADP-ribose) polymerase 1) C Show summary » More detailed page go icon to follow link

PARP2 (poly(ADP-ribose) polymerase 2) C Show summary » More detailed page go icon to follow link

tankyrase Show summary » More detailed page go icon to follow link

tankyrase 2 Show summary » More detailed page go icon to follow link

Further reading

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References

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How to cite this family page

Database page citation:

Poly ADP-ribosylating PARPs. Accessed on 23/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=883.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.