Similar to the LMR RTK family, STYK1 has a truncated extracellular domain, but also displays a relatively short intracellular tail beyond the split kinase domain. Also known as NOK, STYK1 has been linked to EGFR signalling [1-2].

As yet, no selective inhibitors of STYK1 have been described.

1. Ding X, Jiang QB, Li R, Chen S, Zhang S. (2012) NOK/STYK1 has a strong tendency towards forming aggregates and colocalises with epidermal growth factor receptor in endosomes. Biochem Biophys Res Commun, 421 (3): 468-73. [PMID:22516751]

2. Eggermont C, Giron P, Noeparast M, Vandenplas H, Aza-Blanc P, Gutierrez GJ, De Grève J. (2022) The EGFR-STYK1-FGF1 axis sustains functional drug tolerance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer. Cell Death Dis, 13 (7): 611. [PMID:35840561]