Similar to the LMR RTK family, STYK1 has a truncated extracellular domain, but also displays a relatively short intracellular tail beyond the split kinase domain. STYK1 (also known as Novel Oncogene with Kinase-domain, NOK) has been suggested to co-localize with activated EGF receptor [1].

As yet, no selective inhibitors of STYK1 have been described.

1. Ding X, Jiang QB, Li R, Chen S, Zhang S. (2012) NOK/STYK1 has a strong tendency towards forming aggregates and colocalises with epidermal growth factor receptor in endosomes. Biochem Biophys Res Commun, 421 (3): 468-73. [PMID:22516751]