TNK2 (ACK1) is a tyrosine kinase that induces cell survival mechanisms. Substrates include receptor tyrosine kinases (EGFR, MERTK, AXL, HER2 and insulin receptor), AKT, FYN, the androgen receptor and the GTPase Cdc42Hs. TNK2 is associated with tumour cell survival, proliferation and hormone-resistance, and hence TNK2 is considered to be a novel cancer target, although no inhibitors have entered clinical trials.

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