MLK subfamily

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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

MLK1 (mitogen-activated protein kinase kinase kinase 9) Show summary »« Hide summary More detailed page go icon to follow link

MLK2 (mitogen-activated protein kinase kinase kinase 10) Show summary »« Hide summary More detailed page go icon to follow link

MLK3 (mitogen-activated protein kinase kinase kinase 11) Show summary »« Hide summary More detailed page go icon to follow link

ZAK (ZAK sterile alpha motif and leucine zipper containing kinase AZK) Show summary »« Hide summary More detailed page go icon to follow link

Target Id

2289

Nomenclature

ZAK sterile alpha motif and leucine zipper containing kinase AZK

Common abbreviation

ZAK

Previous and unofficial names

Genes

MAP3K20 (Hs), Map3k20 (Mm), Map3k20 (Rn)

Ensembl ID

ENSG00000091436 (Hs), ENSMUSG00000004085 (Mm), ENSRNOG00000001515 (Rn)

UniProtKB AC

Q9NYL2 (Hs), Q9ESL4 (Mm)

EC number

2.7.11.25

References

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1. Goodfellow VS, Loweth CJ, Ravula SB, Wiemann T, Nguyen T, Xu Y, Todd DE, Sheppard D, Pollack S, Polesskaya O et al.. (2013) Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. J Med Chem, 56 (20): 8032-48. [PMID:24044867]

2. Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA et al.. (2001) Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem, 276 (27): 25302-8. [PMID:11325962]

3. Siu M, Sengupta Ghosh A, Lewcock JW. (2018) Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration. J Med Chem, 61 (18): 8078-8087. [PMID:29863360]

How to cite this family page

Database page citation:

MLK subfamily. Accessed on 20/04/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=524.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.