GSK3A and GSK3B are protein Ser/Thr kinases that are involved in the regulation of glycogen synthesis. GSK3B (GSK-3β) has been associated with the pathogenesis and progression of diseases including obesity, diabetes, cancer and Alzheimer's, and as a result pharmacological inhibition of this enzyme is an attractive therapeutic mechanism.

* Key recommended reading is highlighted with an asterisk

* Beurel E, Grieco SF, Jope RS. (2015) Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther, 148: 114-31. [PMID:25435019]

* Domoto T, Pyko IV, Furuta T, Miyashita K, Uehara M, Shimasaki T, Nakada M, Minamoto T. (2016) Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy. Cancer Sci, 107 (10): 1363-1372. [PMID:27486911]

* Khan I, Tantray MA, Alam MS, Hamid H. (2017) Natural and synthetic bioactive inhibitors of glycogen synthase kinase. Eur J Med Chem, 125: 464-477. [PMID:27689729]

* Lauretti E, Dincer O, Praticò D. (2020) Glycogen synthase kinase-3 signaling in Alzheimer's disease. Biochim Biophys Acta Mol Cell Res, 1867 (5): 118664. [PMID:32006534]

Maqbool M, Mobashir M, Hoda N. (2016) Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease. Eur J Med Chem, 107: 63-81. [PMID:26562543]

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