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CDK4 subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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CDK4 and CDK6 are Ser/Thr protein kinases that are components of protein complexes that regulate progression through the G1 phase of the cell cycle. These kinases are important integrators of mitogenic and antimitogenic signals, and are oncology drug targets. CDK4/6 inhibitors are in clinical use (e.g. abemaciclib, ribociclib and palbociclib).


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CDK4 (cyclin dependent kinase 4) C Show summary » More detailed page go icon to follow link

CDK6 (cyclin dependent kinase 6) C Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

CDK4 subfamily. Accessed on 27/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.