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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Inhibition of SIKs is reported to promote a macrophage phenotype switch to a 'regulatory'-like phenotype [2-3], that favours resolution of inflammation. This action of SIKs provides a novel intervention point for pharmacological agents with potential as therapeutics for chronic inflammatory diseases.
SIK (salt inducible kinase 1) Show summary » More detailed page |
QIK (salt inducible kinase 2) Show summary » More detailed page |
QSK (SIK family kinase 3) Show summary » More detailed page |
Database page citation:
QIK subfamily. Accessed on 10/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=483.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.