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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
The salt-inducible kinases (SIKs) control a novel molecular switch regulating macrophage polarization. Inhibition of SIKs is reported to promote a macrophage phenotype switch to a 'regulatory'-like phenotype [2-3], that favours resolution of inflammation. This action of SIKs provides a novel intervention point for pharmacological agents with potential as therapeutics for chronic inflammatory diseases.
SIK (salt inducible kinase 1)
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QIK (salt inducible kinase 2)
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QSK (SIK family kinase 3)
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Database page citation:
QIK subfamily. Accessed on 24/05/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=483.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.