Type XII RTKs: TIE family of angiopoietin receptors | Catalytic receptors

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Type XII RTKs: TIE family of angiopoietin receptors

Type XII RTKs: TIE family of angiopoietin receptors C

Formerly known as: TIE family of angiopoietin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The TIE family were initially associated with formation of blood vessels. Endogenous ligands are angiopoietin-1 (ANGPT1, Q15389), angiopoietin-2 (ANGPT2, O15123), and angiopoietin-4 (ANGPT4, Q9Y264). Angiopoietin-2 (ANGPT2, O15123) appears to act as an endogenous antagonist of angiopoietin-1 function.

Receptors

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1841

Nomenclature

tyrosine kinase with immunoglobulin like and EGF like domains 1

Common abbreviation

TIE1

Previous and unofficial names

TIE | tyrosine kinase receptor 1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Genes

TIE1 (Hs), Tie1 (Mm), Tie1 (Rn)

Ensembl ID

ENSG00000066056 (Hs), ENSMUSG00000033191 (Mm), ENSRNOG00000020173 (Rn)

UniProtKB AC

P35590 (Hs), Q06806 (Mm)

EC number

2.7.10.1

TIE2 (TEK receptor tyrosine kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1842

Nomenclature

TEK receptor tyrosine kinase

Common abbreviation

TIE2

Previous and unofficial names

Genes

TEK (Hs), Tek (Mm), Tek (Rn)

Ensembl ID

ENSG00000120156 (Hs), ENSMUSG00000006386 (Mm), ENSRNOG00000008587 (Rn)

UniProtKB AC

Q02763 (Hs), Q02858 (Mm)

EC number

2.7.10.1

Endogenous ligands

angiopoietin-1 (ANGPT1, Q15389)

angiopoietin-4 (ANGPT4, Q9Y264)

How to cite this family page

Database page citation:

Type XII RTKs: TIE family of angiopoietin receptors. Accessed on 23/05/2025. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=330.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.