Type XII RTKs: TIE family of angiopoietin receptors | Catalytic receptors

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TK: Tyrosine kinase
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Type XII RTKs: TIE family of angiopoietin receptors

Type XII RTKs: TIE family of angiopoietin receptors C

Formerly known as: TIE family of angiopoietin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The TIE family were initially associated with formation of blood vessels (angiogenesis). Endogenous ligands are angiopoietin-1 (ANGPT1, Q15389), angiopoietin-2 (ANGPT2, O15123), and angiopoietin-4 (ANGPT4, Q9Y264). Angiopoietin-2 (ANGPT2, O15123) appears to act as an endogenous antagonist of angiopoietin-1 function, thus blocking TIE2-mediated signalling. Due to roles in blood vessel formation, monoclonal antibodies are being developed against the ligand Ang2 (cyamemazine57) or a bispecific antibody against VEGF and Ang2 (faricimab) for the treatment of ocular diseases.

Receptors

TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1841

Nomenclature

tyrosine kinase with immunoglobulin like and EGF like domains 1

Common abbreviation

TIE1

Previous and unofficial names

TIE | tyrosine kinase receptor 1 | tyrosine kinase with immunoglobulin-like and EGF-like domains 1

Genes

TIE1 (Hs), Tie1 (Mm), Tie1 (Rn)

Ensembl ID

ENSG00000066056 (Hs), ENSMUSG00000033191 (Mm), ENSRNOG00000020173 (Rn)

UniProtKB AC

P35590 (Hs), Q06806 (Mm)

EC number

2.7.10.1

TIE2 (TEK receptor tyrosine kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1842

Nomenclature

TEK receptor tyrosine kinase

Common abbreviation

TIE2

Previous and unofficial names

Genes

TEK (Hs), Tek (Mm), Tek (Rn)

Ensembl ID

ENSG00000120156 (Hs), ENSMUSG00000006386 (Mm), ENSRNOG00000008587 (Rn)

UniProtKB AC

Q02763 (Hs), Q02858 (Mm)

EC number

2.7.10.1

Endogenous ligands

angiopoietin-1 (ANGPT1, Q15389)

angiopoietin-4 (ANGPT4, Q9Y264)

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Peach CJ, Gibb AJ, Kelly E, Mathie AA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors. Br J Pharmacol. 182: S259-S306.