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Type XII RTKs: TIE family of angiopoietin receptors C

Formerly known as: TIE family of angiopoietin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The TIE family were initially associated with formation of blood vessels. Endogenous ligands are angiopoietin-1 (ANGPT1, Q15389), angiopoietin-2 (ANGPT2, O15123), and angiopoietin-4 (ANGPT4, Q9Y264). Angiopoietin-2 (ANGPT2, O15123) appears to act as an endogenous antagonist of angiopoietin-1 function.

Receptors

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TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1) C Show summary » More detailed page go icon to follow link

TIE2 (TEK receptor tyrosine kinase) C Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

Type XII RTKs: TIE family of angiopoietin receptors. Accessed on 03/12/2023. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=330.

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. Br J Pharmacol. 178 Suppl 1:S264-S312.