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Type V RTKs: FGF (fibroblast growth factor) receptor family C

Formerly known as: FGF (fibroblast growth factor) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fibroblast growth factor (FGF) family receptors act as homo- and heterodimers, and are characterized by Ig-like loops in the extracellular domain, in which disulphide bridges may form across protein partners to allow the formation of covalent dimers which may be constitutively active. FGF receptors have been implicated in achondroplasia, angiogenesis and numerous congenital disorders. At least 22 members of the FGF gene family have been identified in the human genome [11]. Within this group, subfamilies of FGF may be divided into canonical, intracellular and hormone-like FGFs. FGF1-FGF10 have been identified to act through FGF receptors, while FGF11-14 appear to signal through intracellular targets. Other family members are less well characterized [7].
Approved FGFR inhibitors include erdafitinib, pemigatinib, and futibatinib. Common adverse effects associated with these drugs, and approaches for their management are reviewed in [6].

Receptors

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FGFR1 (fibroblast growth factor receptor 1) C Show summary » More detailed page go icon to follow link

FGFR2 (fibroblast growth factor receptor 2) C Show summary » More detailed page go icon to follow link

FGFR3 (fibroblast growth factor receptor 3) C Show summary » More detailed page go icon to follow link

FGFR4 (fibroblast growth factor receptor 4) C Show summary » More detailed page go icon to follow link

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Further reading

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References

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How to cite this family page

Database page citation:

Type V RTKs: FGF (fibroblast growth factor) receptor family. Accessed on 05/03/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=323.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.