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CYP2 family: drug metabolising subset C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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CYP1, 2 and 3 family enzymes are involved in the biotransformation of xenobiotics, including clinically used drugs. Polymorphisms, particularly in the CYP2 family, impact upon an individual's response to drugs [30], including the risk of adverse drug reactions, drug efficacy and dose requirement.

Enzymes

1328
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CYP2A6 C Show summary » More detailed page go icon to follow link

CYP2A7 C Show summary »

CYP2A13 C Show summary »

CYP2B6 C Show summary » More detailed page go icon to follow link

CYP2C8 C Show summary » More detailed page go icon to follow link

CYP2C9 C Show summary » More detailed page go icon to follow link

CYP2C18 Show summary »

CYP2C19 C Show summary »


Target Id 1328
Nomenclature CYP2C19
Previous and unofficial names (S)-limonene 6-monooxygenase | (S)-limonene 7-monooxygenase | mephenytoin 4-hydroxylase | cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19 | (R)-limonene 6-monooxygenase | cytochrome P450, family 2, subfamily C, polypeptide 19
Genes CYP2C19 (Hs)
Ensembl ID ENSG00000165841 (Hs)
UniProtKB AC P33261 (Hs)
EC number
1.14.14.51
Inhibitors
compound 30 [PMID: 22239545] pKi 7.7 [10]
Comment Drug substrates include omeprazole, proguanil, mephenytoin, diazepam [3,7,13]. Common genetic polymorphism for null function.

CYP2D6 C Show summary » More detailed page go icon to follow link

CYP2E1 C Show summary » More detailed page go icon to follow link

CYP2F1 C Show summary »

CYP2J2 C Show summary »

References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.