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Organic zwitterions/cation transporters (OCTN) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Organic zwitterions/cation transporters (OCTN) function as organic cation uniporters, organic cation/proton exchangers or sodium/L-carnitine co-transporters.

Transporters

1023
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OCTN1 (Organic cation/carnitine transporter 1 / SLC22A4) C Show summary »

OCTN2 (Organic cation/carnitine transporter 2 / SLC22A5) C Show summary »

Target Id 1023
Nomenclature Organic cation/carnitine transporter 2
Systematic nomenclature SLC22A5
Common abbreviation OCTN2
Previous and unofficial names CT1 | High-affinity sodium-dependent carnitine cotransporter | CDSP | SCD | high-affinity carnitine transporter | solute carrier family 22 (organic cation transporter) member 5 | UST2r | solute carrier family 22 (organic cation/carnitine transporter), member 5 | solute carrier family 22 (organic cation transporter)
Genes SLC22A5 (Hs), Slc22a5 (Mm), Slc22a5 (Rn)
Ensembl ID ENSG00000197375 (Hs), ENSMUSG00000018900 (Mm), ENSRNOG00000008432 (Rn)
UniProtKB AC O76082 (Hs), Q9Z0E8 (Mm), O70594 (Rn)
Bioparadigms SLC Tables SLC22A5 (Hs)
RESOLUTE SLC22A5 (Hs)
Endogenous substrates
acetyl-L-carnitine
L-carnitine
Substrates
mepyramine
tetraethylammonium
verapamil
MPP+
Stoichiometry Unknown

CT2 (Carnitine transporter 2 / SLC22A16) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.