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P2A P-type ATPases: Ca2+-ATPases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) is an intracellular membrane-associated pump for sequestering calcium from the cytosol into intracellular organelles, usually associated with the recovery phase following excitation of muscle and nerves.

The plasma membrane Ca2+-ATPase (PMCA) is a cell-surface pump for extruding calcium from the cytosol, usually associated with the recovery phase following excitation of cells. The active pump is a homodimer, each subunit of which is made up of ten TM segments, with cytosolic C- and N-termini and two large intracellular loops.

Secretory pathway Ca2+-ATPases (SPCA) allow accumulation of calcium and manganese in the Golgi apparatus.


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SERCA1 Show summary »

Target Id 840
Nomenclature SERCA1
Previous and unofficial names Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | ATP2A | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | calcium pump 1 | endoplasmic reticulum class 1/2 Ca(2+) ATPase | SR Ca(2+)-ATPase 1 | ATPase, Ca� transporting, cardiac muscle, fast twitch 1 | ATPase
Genes ATP2A1 (Hs), Atp2a1 (Mm), Atp2a1 (Rn)
Ensembl ID ENSG00000196296 (Hs), ENSMUSG00000030730 (Mm), ENSRNOG00000047124 (Rn)
UniProtKB AC O14983 (Hs), Q8R429 (Mm), Q64578 (Rn)
EC number
Allosteric modulators
CDN1163 (Activation) pEC50 5.2 [6] - Rabbit
TGN4 (Negative) pIC50 8.9 [5]

SERCA2 Show summary »

SERCA3 Show summary »


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How to cite this family page

Database page citation:

P2A P-type ATPases: Ca2+-ATPases. Accessed on 21/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.