Translational GTPases

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Translational GTPases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Translational GTPases (trGTPases) play key roles in facilitating protein synthesis on the ribosome, acting as eukaryotic translation initiation or elongation factors. They share conserved GTP-binding domains, but reaction kinetics are considerably variable between family members (19 genes in the human genome).
We include members of this family that are potential therapeutic targets.

Enzymes

HBS1 like translational GTPase Show summary »« Hide summary

Target Id	3350
Nomenclature	HBS1 like translational GTPase
Genes	HBS1L (Hs), Hbs1l (Mm), Hbs1l (Rn)
Ensembl ID	ENSG00000112339 (Hs), ENSMUSG00000019977 (Mm), ENSRNOG00000014531 (Rn)
UniProtKB AC	Q9Y450 (Hs), Q69ZS7 (Mm), Q6AXM7 (Rn)
Comment	The HBS1L gene encodes a GTP-binding elongation factor that is a component of the HBS1L/PELO ribosome-rescue complex [2-3]. HBS1L influnces erythrocyte, platelet, and monocyte counts, and erythrocyte volume and hemoglobin content. DNA polymorphisms associate with fetal hemoglobin levels and pain crises in sickle cell disease, and with severity in β-thalassemia/Hemoglobin E. HBS1L has also been identified as a synthetic lethal target for anti-tumour drug development [1].

References

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1. Nicholson HE, Whittington DA, Bruzzese FJ, Lazarides K, Martires LCM, Tonini MR, Jenkins HN, Zhang M, Shahagadkar P, Pratt CB et al.. (2026) TNG961 is a selective oral HBS1L molecular glue degrader for the treatment of FOCAD-deleted cancers. Cancer Discov, [Epub ahead of print]. [PMID:42001523]

2. Saito S, Hosoda N, Hoshino S. (2013) The Hbs1-Dom34 protein complex functions in non-stop mRNA decay in mammalian cells. J Biol Chem, 288 (24): 17832-43. [PMID:23667253]

3. Shao S, Murray J, Brown A, Taunton J, Ramakrishnan V, Hegde RS. (2016) Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167 (5): 1229-1240.e15. [PMID:27863242]

How to cite this family page

Database page citation:

Translational GTPases. Accessed on 16/06/2026. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1130.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Gibb AJ, Kelly E, Mathie AA, Peach CJ, Veale EL, Armstrong JF, Faccenda E, Harding SD, Southan C, Davies JA et al. (2025) The Concise Guide to PHARMACOLOGY 2025/26: Enzymes. Br J Pharmacol. 182: S307-S403.