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Protein phosphatase catalytic subunits

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3264
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protein phosphatase 1 catalytic subunit alpha Show summary »


Target Id 3264
Nomenclature protein phosphatase 1 catalytic subunit alpha
Previous and unofficial names dism2 | PP1A | PP1alpha | Ppp1c | protein phosphatase 1, catalytic subunit, alpha isoform
Genes PPP1CA (Hs), Ppp1ca (Mm), Ppp1ca (Rn)
Ensembl ID ENSG00000172531 (Hs), ENSMUSG00000040385 (Mm), ENSRNOG00000018708 (Rn)
UniProtKB AC P62136 (Hs), P62137 (Mm), P62138 (Rn)
EC number
3.1.3.16
Inhibitors
microcystin-LR pIC50 10.0 [9]
calyculin A pIC50 9.0 [7]
okadaic acid pIC50 7.2 [7]
cantharidin pIC50 6.8 [7]
Comment Component of the protein phosphatase type 1 complex which dephosphorylates numerous substrate proteins [8,10]. Notably it is important for cell division, the regulation of glycogen metabolism and synaptic plasticity.

protein phosphatase 2 catalytic subunit alpha Show summary »

References

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How to cite this family page

Database page citation:

Protein phosphatase catalytic subunits. Accessed on 30/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1092.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.