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Nucleoside synthesis and metabolism (Plasmodium spp.)

Overview

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During the asexual blood stage of development, the malaria parasite exhibits rapid nucleic acid synthesis. Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their human host and provide promising targets for novel drug development.

Targets

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PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) C Show summary » More detailed page go icon to follow link

PfPDEalpha (Plasmodium falciparum cGMP-specific phosphodiesterase) C Show summary » More detailed page go icon to follow link

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) C Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism (Plasmodium spp.). Accessed on 17/04/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1060.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.