Nucleoside synthesis and metabolism (<i>Plasmodium</i> spp.) | Other protein targets

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Nucleoside synthesis and metabolism (Plasmodium spp.)

Nucleoside synthesis and metabolism (Plasmodium spp.)

Overview

During the asexual blood stage of development, the malaria parasite exhibits rapid nucleic acid synthesis. Plasmodium purine and pyrimidine metabolic pathways are distinct from those of their human host and provide promising targets for novel drug development.

Targets

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	2949
Nomenclature	Plasmodium falciparum dihydroorotate dehydrogenase
Common abbreviation	PfDHODH
Previous and unofficial names	DHODH \| dihydroorotate dehydrogenase \| Pfal DHODH
Genes	DHODH (Pf3D7)
UniProtKB AC	Q08210 (Pf3D7)
PlasmoDB	PF3D7_0603300 (Pf3D7)

PfPDEalpha (Plasmodium falciparum cGMP-specific phosphodiesterase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3091
Nomenclature	Plasmodium falciparum cGMP-specific phosphodiesterase
Common abbreviation	PfPDEalpha
Previous and unofficial names	PDEalpha \| cGMP-specific 3',5'-cyclic phosphodiesterase alpha \| PfPDE1
Genes	PDEalpha (Pf3D7)
UniProtKB AC	Q8I5V4 (Pf3D7)
PlasmoDB	PF3D7_1209500 (Pf3D7)

PfPNP (Plasmodium falciparum purine nucleoside phosphorylase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id	3077
Nomenclature	Plasmodium falciparum purine nucleoside phosphorylase
Common abbreviation	PfPNP
Previous and unofficial names	PNP \| purine nucleoside phosphorylase
Genes	PNP (Pf3D7)
UniProtKB AC	Q8I3X4 (Pf3D7)
PlasmoDB	PF3D7_0513300 (Pf3D7)

How to cite this family page

Database page citation:

Nucleoside synthesis and metabolism (Plasmodium spp.). Accessed on 18/09/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1060.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Introduction and Other Protein Targets. Br J Pharmacol. 176 Issue S1: S1-S20.