Top ▲

Acyl-CoA synthetases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


Click here for help

« Hide

ACSS2 is a monomeric cytosolic enzyme that catalyses the formation of acetyl-CoA from acetate, CoA, and ATP. It plays a role in the biosynthesis of cholesterol, glucose, and fatty acids. ACSS2 is also a drug target for cancer and neurodegenerative diseases [1].


Click here for help

acyl-CoA synthetase short chain family member 2 Show summary » More detailed page go icon to follow link


Click here for help

Show »

How to cite this family page

Database page citation:

Acyl-CoA synthetases. Accessed on 20/05/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.