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Glycine recycling

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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The glycine cleavage system (a.k.a. the glycine decarboxylase complex) is active at mitochondria. It contains four loosely associated proteins that catalyse the following (reversible) reaction: Glycine + tetrahydrofolate + NAD+ <-> 5,10-methylenetetrahydrofolate + CO2 + NH3 + NADH + H+.


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glycine cleavage system protein H Show summary » More detailed page go icon to follow link


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How to cite this family page

Database page citation:

Glycine recycling. Accessed on 21/06/2024. IUPHAR/BPS Guide to PHARMACOLOGY,

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.