2.3.2.13 Transglutaminases

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2.3.2.- Aminoacyltransferases
2.3.2.13 Transglutaminases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Transglutaminases catalyse an acyl transferase reaction of γ-carboxamide groups of glutamine residues (on the donor peptide) with ε-amino groups of lysine residues (on an acceptor peptide) which creates a crosslink between the two proteins. This enzymatic activity is calcium-dependent, and the bonds that are formed are highly resistant to proteolytic cleavage. Nine human transglutaminase-encoding genes have been identified, but only 8 are known to be enzymatically active.

Enzymes

transglutaminase 2 Show summary »« Hide summary More detailed page go icon to follow link

Target Id

3015

Nomenclature

transglutaminase 2

Previous and unofficial names

transglutaminase 2, C polypeptide | C polypeptide, protein-glutamine-gamma-glutamyltransferase | TGC | tissue transglutaminase | TGase2

Genes

TGM2 (Hs), Tgm2 (Mm), Tgm2 (Rn)

Ensembl ID

ENSG00000198959 (Hs), ENSMUSG00000037820 (Mm), ENSRNOG00000012956 (Rn)

UniProtKB AC

P21980 (Hs), P21981 (Mm)

EC number

2.3.2.13
A protein-L-glutamine + a protein-L-lysine <=> a protein with an N₆-(gamma-glutamyl)-L-lysine cross-link + NH₃

How to cite this family page

Database page citation:

2.3.2.13 Transglutaminases. Accessed on 24/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1003.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.