Top ▲

2.3.2.13 Transglutaminases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

Click here for help

« Hide

Transglutaminases catalyse an acyl transferase reaction of γ-carboxamide groups of glutamine residues (on the donor peptide) with ε-amino groups of lysine residues (on an acceptor peptide) which creates a crosslink between the two proteins. This enzymatic activity is calcium-dependent, and the bonds that are formed are highly resistant to proteolytic cleavage. Nine human transglutaminase-encoding genes have been identified, but only 8 are known to be enzymatically active.

Enzymes

Click here for help

transglutaminase 2 Show summary » More detailed page go icon to follow link

How to cite this family page

Database page citation:

2.3.2.13 Transglutaminases. Accessed on 11/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1003.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.