levetiracetam [Ligand Id: 6826] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1286 (Keppra, UCB-L059, Elepsia, AGB-101, Levetiracetame, UCB-22059, Desitrend, Levetiracetam hospira, UCB 22059, Levetiracetam sun, Levetiracetam actavis, Levetiracetam accord, Levetiracetam teva, UCB L059, N03AX14, Levetiracetam ratiopharm, Keppra xr, Matever, Levetiracetam in sodium chloride, Spritam, Elepsia xr, Levetiracetam, Levetiracetam actavis group, NSC-760119) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| carbonic anhydrase 1/Carbonic anhydrase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human CA1 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.1 | pKi | 7950 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 12/Carbonic anhydrase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human CA12 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 7.27 | pKi | 54 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 13/Carbonic anhydrase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Inhibition of human CA13 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.38 | pKi | 4170 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 14/Carbonic anhydrase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibition of human CA14 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.64 | pKi | 2270 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 2/Carbonic anhydrase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human CA2 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.41 | pKi | 3920 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| Carbonic anhydrase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human CA3 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.61 | pKi | 2440 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 4/Carbonic anhydrase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human CA4 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.28 | pKi | 5300 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 5A/Carbonic anhydrase 5A, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibition of human CA VA preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.04 | pKi | 9200 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| Carbonic anhydrase 5B, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibition of human CA VB preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.41 | pKi | 3860 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| Carbonic anhydrase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human CA6 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.08 | pKi | 8400 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 7/Carbonic anhydrase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human CA7 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 5.12 | pKi | 7550 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| carbonic anhydrase 9/Carbonic anhydrase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human CA9 preincubated for 15 mins by phenol red staining based stopped flow CO2 hydrase assay | B | 7.05 | pKi | 89 | nM | Ki | ACS Med Chem Lett (2024) 15: 2133-2139 [PMID:39691524] |
| synaptic vesicle glycoprotein 2A in Rat [GtoPdb: 2634] [UniProtKB: Q02563] | ||||||||
| GtoPdb | - | - | 5.8 | pKi | 1580 | nM | Ki | Eur J Pharmacol (1995) 286: 137-46 [PMID:8605950] |
| GtoPdb | In vitro inhibitory activity against [3H](2S)-2-[4-(3-azidophenyl)-2-oxopyrrolidin-1-yl]butanamide binding to levetiracetam binding site, in rat brain homogenate | - | 6.1 | pIC50 | 794 | nM | IC50 | J Med Chem (2004) 47: 530-49 [PMID:14736235] |
ChEMBL data shown on this page come from version 37:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
