ChEMBL ligand: CHEMBL18 (Cardrase, Ethamide, Ethoxzolamide, NSC-10679)
AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] There should be some charts here, you may need to enable JavaScript!
Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] There should be some charts here, you may need to enable JavaScript!
Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] There should be some charts here, you may need to enable JavaScript!
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 3 in Bovine [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.73	pKi	185	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	B	7.4	pKi	39.4	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.4	pKi	39.4	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	6.41	pKi	387	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.03	pKi	9.3	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	B	6.13	pKi	740	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	6.98	pKi	105	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	B	5.27	pKi	5350	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL	Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay	B	5.97	pKi	1070	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	B	5.97	pKi	1070	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay	B	5.97	pKi	1070	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2508-2511 [PMID:20299219]
ChEMBL	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	5.97	pKi	1070	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	5.51	pKi	3125	nM	Ki	Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assay	B	4.8	pKi	16000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6327-6331 [PMID:18993072]
ChEMBL	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	B	7.01	pKi	98.4	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL	Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay	B	6.71	pKi	193	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of Helicobacter pylori recombinant CA	B	6.81	pKi	155	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay	B	7.24	pKi	58	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 15 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.24	pKi	58	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.06	pKi	87	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4]
ChEMBL	Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	5.02	pKi	9443	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL	Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.39	pKi	4.1	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assay	B	7.85	pKd	14	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay	B	7.85	pKd	14	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate	B	5.43	pKi	3750	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	5.43	pKi	3750	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21	B	5.92	pKi	1200	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-54 [PMID:15686931]; Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I (CA1)	B	7.6	pKi	25	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I (CA1)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory activity against human carbonic anhydrase I.	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase I (hCAI)	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against Human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Ki value against human carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Ki value against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCAI)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase I	F	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition constant against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA1	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant isozyme CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of full length human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of full length human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 1 by by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition constant determined against human cloned carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of full length carbonic anhydrase-1 in human erythrocytes	B	7.8	pIC50	15.71	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Binding affinity to human recombinant CA2 at 37 degC and pH 7.0 by thermal shift assay	B	8.96	pKd	1.1	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of carbonic anhydrase 2 assessed as inhibition of carbon dioxide hydration	B	0.9	pKi	0.9	-	logKi	Eur J Med Chem (2009) 44: 3439-3444 [PMID:19303173]
ChEMBL	Inhibitory activity against human carbonic anhydrase II at 0.01 uM	B	5.1	pKi	8000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate	B	6.49	pKi	320	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.49	pKi	320	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	6.75	pKi	178	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.16	pKi	69.7	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21	B	7.42	pKi	38	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase II (hCA II)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibition of human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II (CA2)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory activity against human carbonic anhydrase II.	B	8.1	pKi	8	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase II (hCAII)	B	8.1	pKi	8	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against Human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Ki value against human carbonic anhydrase II (hCA II)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Ki value against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCAII)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase II	F	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition constant against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II (hCA II)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibitory activity against human recombinant cytosolic CA2	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA2	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of human cloned CA2 by stopped-flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method	B	8.1	pKi	8	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant isozyme CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant full length CA2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of full length human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)	B	8.1	pKi	8	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of human recombinant carbonic anhydrase II (CA2)	B	8.1	pKi	8	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C	B	8.1	pKi	8	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	8.1	pKi	8	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of full length human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
ChEMBL	Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 2 by by stopped flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method	B	8.27	pKi	5.4	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2315-2320 [PMID:15837316]
ChEMBL	In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dansylamide	B	9.31	pKi	0.49	nM	Ki	J Med Chem (1987) 30: 591-597 [PMID:3560154]
ChEMBL	50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes	B	8.52	pIC50	3	nM	IC50	J Med Chem (1989) 32: 2548-2554 [PMID:2585443]
ChEMBL	In vitro inhibition of human Carbonic Anhydrase II	B	8.52	pIC50	3	nM	IC50	J Med Chem (1989) 32: 2486-2492 [PMID:2810337]
ChEMBL	In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (1987) 30: 591-597 [PMID:3560154]
ChEMBL	Inhibition of full length carbonic anhydrase-2 in human erythrocytes	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL	Inhibition of human carbonic anhydrase 3	B	5.3	pKi	5000	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate	B	6.08	pKi	840	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.08	pKi	840	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human carbonic anhydrase 4	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibitory activity against human carbonic anhydrase IV (hCAIV)	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human cloned CA4 by stopped-flow CO2 hydration method	B	7.03	pKi	93	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes	B	7.89	pKi	13	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes	B	7.89	pKi	13	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes	B	7.89	pKi	13	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C	B	7.89	pKi	13	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)	B	7.89	pKi	13	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV	B	7.89	pKi	13	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX at 0.09 uM	B	4.47	pKi	34000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory activity against human Carbonic anhydrase IX (hCA IX)	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase IX catalytic domain	F	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.37	pKi	43	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.46	pKi	34.3	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX.	B	7.47	pKi	34	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	Inhibitory activity against Carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition constant against human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.47	pKi	34	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human recombinant CA IX	B	7.47	pKi	34	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned catalytic domain CA9 by CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human CA9 catalytic domain by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay	B	7.47	pKi	34	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human carbonic anhydrase 9 by by stopped flow CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibition against human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.	B	7.47	pKi	34	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)	B	9	pIC50	0.99	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	9.6	pIC50	0.25	nM	IC50	Medchemcomm (2018) 9: 2100-2105 [PMID:30746068]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VA	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human cloned CA5A by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human carbonic anhydrase 5A	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VB	B	7.72	pKi	19	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human cloned CA5B by stopped-flow CO2 hydration method	B	7.72	pKi	19	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human carbonic anhydrase 5B	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped flow CO2 hydration assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay	B	7.48	pKd	33	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate	B	5.8	pKi	1580	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	5.8	pKi	1580	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human recombinant CA VI	B	7.37	pKi	43	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.37	pKi	43	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human carbonic anhydrase 6	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Binding affinity to human recombinant CA7 at 37 degC and pH 7.0 by thermal shift assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human cloned CA7 by stopped-flow CO2 hydration method	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human carbonic anhydrase 7	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
GtoPdb	-	-	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175]
ChEMBL	Ki value against human carbonic anhydrase VII	B	9.11	pKi	0.78	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Binding affinity to human recombinant CA12 at 37 degC and pH 7.0 by thermal shift assay	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.25	pKi	56	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22.1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase XII	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition constant against human carbonic anhydrase XII	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase XII (hCA XII)	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method	B	7.66	pKi	22	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human carbonic anhydrase 12	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118]
ChEMBL	Inhibition of human carbonic anhydrase 12 by by stopped flow CO2 hydration method	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Ki value against human carbonic anhydrase XII (hCA XII)	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibitory activity against catalytic domain of human carbonic anhydrase XII	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
GtoPdb	-	-	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL	Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay	B	7.89	pKd	13	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7.89	pKd	13	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-33 [PMID:16039848]
ChEMBL	Inhibition of human recombinant CA14 by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of human carbonic anhydrase 14	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human cloned CA14 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of full length human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
ChEMBL	Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.07	pKi	85.1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	B	5.99	pKi	1030	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]