brinzolamide [Ligand Id: 6797] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL220491 (AL-4862, Azopt, Brinzolamida, Brinzolamide, NSC-760050) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
| ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.5 | pKi | 31.4 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] | ||||||||
| ChEMBL | Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay | B | 7.32 | pKi | 48.2 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | B | 7.32 | pKi | 48.2 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
| ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.56 | pKi | 278 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
| ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 7.91 | pKi | 12.3 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] | ||||||||
| ChEMBL | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay | B | 6.9 | pKi | 127 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] | ||||||||
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.77 | pKi | 169 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] | ||||||||
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay | B | 5.96 | pKi | 1095 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 5.96 | pKi | 1095 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] | ||||||||
| ChEMBL | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 5.36 | pKi | 4350 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020] |
| Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay | B | 6.94 | pKi | 114 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] | ||||||||
| ChEMBL | Inhibition of Helicobacter pylori recombinant CA | B | 6.61 | pKi | 246 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay | B | 6.68 | pKi | 210 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] | ||||||||
| ChEMBL | Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 7.06 | pKi | 87 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
| ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 8.38 | pKi | 4.2 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of full length human CA 1 | B | 4.35 | pKi | 45000 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA1 | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method | B | 4.35 | pKi | 45000 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 4.35 | pKi | 45000 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.35 | pKi | 45000 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| GtoPdb | - | - | 4.35 | pKi | 45000 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration method | B | 6.35 | pKi | 450 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay | B | 6.35 | pKi | 450 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration method | B | 6.35 | pKi | 450 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2006) 49: 6539-6548 [PMID:17064072] |
| ChEMBL | Inhibition of human recombinant isozyme CA1 by CO2 hydration method | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2007) 50: 1651-1657 [PMID:17343373] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II) by esterase method | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903] |
| ChEMBL | Compound was evaluated for binding affinity against human carbonic anhydrase II (hCA -II) | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1787-1791 [PMID:11425561] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method. | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against Human Carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Binding affinity against Carbonic anhydrase II | B | 9.89 | pKd | -9.89 | - | Log Kd | J Med Chem (2002) 45: 2770-2780 [PMID:12061879] |
| ChEMBL | Binding affinity to human carbonic anhydrase 2 incubated for 1 hr using labeled BODIPY558/568-acetazolamide as tracer by fluorescence polarization tight binding assay | B | 10.05 | pKd | 0.09 | nM | Kd | J Med Chem (2015) 58: 2821-2833 [PMID:25728019] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | B | 7.34 | pKi | 45.3 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Compound was evaluated for binding affinity against bovine carbonic anhydrase IV (bCA IV) | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1787-1791 [PMID:11425561] |
| ChEMBL | Inhibition of human recombinant isozyme CA2 by CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2007) 50: 1651-1657 [PMID:17343373] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2006) 49: 6539-6548 [PMID:17064072] |
| ChEMBL | Inhibition of human carbonic anhydrase2 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.49 | pKi | 3.2 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853] |
| ChEMBL | Inhibitory activity against cytosolic human carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Ki value against human carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Ki value against human carbonic anhydrase II (hCA II) | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21 | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibitory activity against human recombinant cytosolic CA2 | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA2 | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human cloned CA2 by stopped-flow CO2 hydration method | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration method | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration method | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| ChEMBL | Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibition of human carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332] |
| ChEMBL | Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH) | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556] |
| ChEMBL | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of full length human CA 2 | B | 8.52 | pKi | 3 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2020) 63: 3317-3326 [PMID:32031797] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay | B | 9.9 | pKi | 0.13 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 939-943 [PMID:23317571] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in enzyme activity incubated for 30 mins by fluorescence polarization assay | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2015) 58: 2821-2833 [PMID:25728019] |
| ChEMBL | Concentration which produces 50% inhibition of human Carbonic anhydrase II | B | 8.49 | pIC50 | 3.2 | nM | IC50 | J Med Chem (2002) 45: 888-893 [PMID:11831900] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay | B | 5.4 | pKi | 3950 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Concentration which produces 50% Inhibition of human Carbonic anhydrase IV | B | 7.34 | pIC50 | 45.3 | nM | IC50 | J Med Chem (2002) 45: 888-893 [PMID:11831900] |
| Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323] | ||||||||
| ChEMBL | Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV). | B | 7.34 | pKi | 45.3 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846] |
| ChEMBL | Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes | B | 7.35 | pKi | 45 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method. | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human cloned Carbonic Anhydrase isozyme(bCA IV) | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV | B | 7.35 | pKi | 45 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibition of human CA9 catalytic domain by CO2 hydration method | B | 7.33 | pKi | 47 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay | B | 7.33 | pKi | 47 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human cloned catalytic domain CA9 by CO2 hydration method | B | 7.33 | pKi | 47 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760] |
| ChEMBL | Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2007) 50: 1651-1657 [PMID:17343373] |
| ChEMBL | Inhibition of human cloned CA9 catalytic domain by CO2 hydration method | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2006) 49: 6539-6548 [PMID:17064072] |
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase IX | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21 | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase IX | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of catalytic domain of human recombinant CA IX | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human CA 9 catalytic domain | B | 7.43 | pKi | 37 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method. | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase IX | B | 7.43 | pKi | 37 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX. | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay | B | 7.43 | pKi | 37 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.44 | pKi | 36 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VA | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human cloned CA5A by stopped-flow CO2 hydration method | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 5A | B | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay | B | 7.3 | pKi | 50 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VB | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human cloned CA5B by stopped-flow CO2 hydration method | B | 7.52 | pKi | 30 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 5B | B | 7.52 | pKi | 30 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay | B | 7.52 | pKi | 30 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of full length human recombinant CA VI | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human carbonic anhydrase 6 | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 9.05 | pKi | 0.9 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase6 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 9.05 | pKi | 0.9 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| GtoPdb | - | - | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| ChEMBL | Ki value against human carbonic anhydrase VII | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Inhibition of human cloned CA7 by stopped-flow CO2 hydration method | B | 8.55 | pKi | 2.8 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 7 | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human carbonic anhydrase7 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.55 | pKi | 2.8 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118] |
| ChEMBL | Inhibition of human carbonic anhydrase12 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.51 | pKi | 3.1 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| GtoPdb | - | - | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894] |
| ChEMBL | Ki value against human carbonic anhydrase XII (hCA XII) | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant CA12 by CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501] |
| ChEMBL | Inhibition of human carbonic anhydrase 12 | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibitory activity against catalytic domain of human carbonic anhydrase XII | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853] |
| ChEMBL | Inhibition of human CA 12 catalytic domain | B | 8.52 | pKi | 3 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase XII | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.96 | pKi | 11 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| GtoPdb | - | - | 4.15 | pKi | 70000 | nM | Ki | J Biol Chem (1992) 267: 25044-50 [PMID:1460006] |
| ChEMBL | Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibition of human cloned CA14 by stopped-flow CO2 hydration method | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant CA14 by CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501] |
| ChEMBL | Inhibition of human carbonic anhydrase 14 | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human carbonic anhydrase14 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.62 | pKi | 24 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
| ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 6.93 | pKi | 118 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay | B | 6.7 | pKi | 201 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay | B | 6.08 | pKi | 839 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay | B | 6.08 | pKi | 839 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
