Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL27 (AY-64043-, Betalong, .beta.-propranolol, Dl-propranolol, Euprovasin, Inderal, Inderide-40/25, Inderide-80/25, Propranolol, Proprasylyt, Reducor) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
ChEMBL | Antagonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as NECA-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type A2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
ChEMBL | Antagonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as IB MECA-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type A3 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
ChEMBL | Antagonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as EP-induced calcium by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type alpha 1A receptor expressed in CHO cells assessed as calcium level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
ChEMBL | Antagonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type alpha 2A receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
ChEMBL | Antagonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as epinephrine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type alpha 2C receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
ChEMBL | Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in CGP 12177-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 6.7 | pKd | 199.53 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Displacement of [3H]-CGP 12177 from human beta-1 adrenergic receptor expressed in CHOK1 cells | B | 8.22 | pKd | 6.03 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Antagonist activity at human beta-1 adrenergic receptor site 1 expressed in cimeterol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 8.74 | pKd | 1.82 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Displacement of [3H]-CGP12177 from human beta1 ADR expressed in HEK293T cell membranes after 90 mins by scintillation counting | B | 7.93 | pKi | 11.75 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
ChEMBL | Inhibition of [3H]dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes. | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (1993) 36: 157-161 [PMID:8093626] |
ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 8.83 | pKi | 1.47 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Displacement of [3H]CGP12177 from human beta1 adrenoceptor expressed in HEK293T cell membranes | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
ChEMBL | Antagonist activity at human beta1 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay | F | 6.6 | pIC50 | 251.19 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Tested for Beta-1 adrenergic receptor selectivity in canine cardiac tissue in anesthetized dogs | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (1990) 33: 2883-2891 [PMID:1976812] |
ChEMBL | DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) | B | 8.59 | pIC50 | 2.54 | nM | IC50 | DrugMatrix in vitro pharmacology data |
β1-adrenoceptor/Beta-1 adrenergic receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3440] [GtoPdb: 28] [UniProtKB: P34971] | ||||||||
ChEMBL | Displacement of [3H]CGP12177 from mouse beta1 adrenoceptor expressed in HEK293T cell membranes | B | 8.62 | pKi | 2.4 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
β1-adrenoceptor/Beta-1 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3252] [GtoPdb: 28] [UniProtKB: P18090] | ||||||||
ChEMBL | Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for S-enantiomer) | F | 5.58 | pKd | 2630.27 | nM | Kd | J Med Chem (1998) 41: 1613-1618 [PMID:9572886] |
ChEMBL | Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atria | F | 8.36 | pKd | 4.37 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
ChEMBL | Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated rat atria | F | 8.36 | pKd | 4.37 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
ChEMBL | Beta-1 adrenergic receptor-Antagonism in isolated rat heart ventricle. ( for R-enantiomer) | F | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1998) 41: 1613-1618 [PMID:9572886] |
ChEMBL | Apparent dissociation constant towards beta-1 adrenergic receptor in rat heart membranes using (2-6)x10E-9M of [3AH]-DHA in the presence or absence of 10e-5 M (+/-) propranolol. | B | 9.7 | pKd | 0 | M | KD' | J Med Chem (1987) 30: 722-726 [PMID:3031293] |
ChEMBL | Displacement of [3H]CGP12177 from beta-1 adrenergic receptor in rat cerebral cortex by liquid scintillation counting | B | 5.01 | pKi | 9700 | nM | Ki | Bioorg Med Chem (2009) 17: 1345-1352 [PMID:19131251] |
ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor Y356A mutant expressed in CHO cells | F | 6.7 | pKi | 199.53 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor S190A mutant expressed in CHO cells | F | 7.4 | pKi | 39.81 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor Y356F mutant expressed in CHO cells | F | 7.5 | pKi | 31.62 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
ChEMBL | Displacement of [3H]-CGP-12177 from beta1-adrenergic receptor in rat brain cortex after 1 hr by Microbeta scintillation counting method | B | 7.82 | pKi | 15 | nM | Ki | Eur J Med Chem (2018) 147: 102-114 [PMID:29425815] |
ChEMBL | Antagonist activity at rat beta-1 adrenergic receptor W134A mutant expressed in CHO cells | F | 8 | pKi | 10 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
ChEMBL | Displacement of [3H]CGP-12177 from beta1 adrenergic receptor in rat brain cerebral cortex after 60 mins by microbeta scintillation counting method | B | 8.15 | pKi | 7 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 5315-5321 [PMID:27692547] |
ChEMBL | Antagonist activity at rat wild type beta-1 adrenergic receptor expressed in CHO cells | F | 8.5 | pKi | 3.16 | nM | Ki | J Med Chem (2006) 49: 3467-3477 [PMID:16759089] |
ChEMBL | Displacement of [3H]CGP12177 from beta1 adrenoreceptor in Rattus norvegicus (rat) cerebral cortex by liquid scintillation counting | B | 8.52 | pKi | 3 | nM | Ki | Med Chem Res (2008) 17: 507-514 |
Beta-1 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5471] [UniProtKB: B0FL73] | ||||||||
ChEMBL | Inhibition of beta1-adrenergic receptor in guinea pig auricle assessed as reversal of isoproterenol-induced effect | B | 6.6 | pKd | 253.4 | nM | Kd | J Med Chem (1978) 21: 68-72 [PMID:22756] |
ChEMBL | Competitive antagonist activity at beta-1 adrenergic receptor in guinea pig assessed as inhibition of isoproterenol-induced atrial contractile force | B | 7.85 | pKd | 14.13 | nM | Kd | J Med Chem (1979) 22: 210-214 [PMID:34040] |
ChEMBL | Cardioselectivity for the beta-1 adrenergic receptor was determined against isoprenaline (antagonism) in isolated guinea pig trachea | F | 7.9 | pKd | 12.59 | nM | Kd | J Med Chem (1987) 30: 1003-1011 [PMID:2884312] |
ChEMBL | Competitive antagonist activity at beta-1 adrenergic receptor in guinea pig assessed as inhibition of isoproterenol-induced atrial beat rate | B | 8.02 | pKd | 9.55 | nM | Kd | J Med Chem (1979) 22: 210-214 [PMID:34040] |
ChEMBL | Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria | F | 8.06 | pKd | 8.71 | nM | Kd | J Med Chem (1981) 24: 994-998 [PMID:6120237] |
ChEMBL | Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB) | F | 8.51 | pKd | 3.09 | nM | Kd | J Med Chem (1984) 27: 857-861 [PMID:6330358] |
ChEMBL | Beta-1 adrenergic receptor activation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium | B | 8.6 | pKd | 2.51 | nM | Kd | J Med Chem (1988) 31: 2122-2126 [PMID:2903245] |
ChEMBL | Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig | F | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1980) 23: 620-624 [PMID:6104730] |
ChEMBL | Beta-1 adrenergic receptor blocking activity in atria of guinea pig. | B | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1984) 27: 1291-1294 [PMID:6148422] |
ChEMBL | In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atria | B | 8.62 | pKd | 2.4 | nM | Kd | J Med Chem (1985) 28: 896-900 [PMID:2861288] |
ChEMBL | Antagonist activity at beta1 adrenoceptor in guinea pig atrium assessed as inhibition of isoproterenol-induced response after 20 mins | B | 8.7 | pKd | 2 | nM | Kd | J Med Chem (1978) 21: 1081-1084 [PMID:31474] |
ChEMBL | Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation | B | 8.7 | pKd | 2 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
ChEMBL | In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated guinea pig atria | B | 8.76 | pKd | 1.74 | nM | Kd | J Med Chem (1986) 29: 1065-1080 [PMID:2872332] |
ChEMBL | In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea pig atrial preparations | B | 8.76 | pKd | 1.74 | nM | Kd | J Med Chem (1983) 26: 950-957 [PMID:6134834] |
ChEMBL | Inhibitory activity against beta-1 adrenergic receptor in guinea pig atria is determined | B | 7.46 | pIC50 | 34.67 | nM | IC50 | J Med Chem (1993) 36: 3077-3086 [PMID:8230093] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
ChEMBL | Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes assessed as intrinsic Kd by liquid scintillation counting | B | 6.82 | pKd | 150 | nM | Kd | J Med Chem (2016) 59: 5780-5789 [PMID:27239696] |
ChEMBL | Binding affinity to human adrenergic beta2 receptor | B | 9.1 | pKd | 0.79 | nM | Kd | Eur J Med Chem (2009) 44: 2840-2846 [PMID:19168263] |
ChEMBL | Displacement of [3H]-CGP 12177 from human beta-2 adrenergic receptor expressed in CHOK1 cells | B | 9.22 | pKd | 0.6 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Antagonist activity at human beta-2 adrenergic receptor expressed in salbutamol-stimulated CHO-K1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 9.62 | pKd | 0.24 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Displacement of [3H]DHA from inactive/G protein-uncoupled human beta2-AR expressed in CHO cell membranes by liquid scintillation counting | B | 10 | pKd | 0.1 | nM | Kd | J Med Chem (2016) 59: 5780-5789 [PMID:27239696] |
ChEMBL | Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis | B | 8.43 | pKi | 3.69 | nM | Ki | Bioorg Med Chem (2014) 22: 234-246 [PMID:24326276] |
ChEMBL | Displacement of [3H]-CGP12177 from human beta2 ADR expressed in HEK293T cell membrane after 90 mins by scintillation counting | B | 8.76 | pKi | 1.74 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 9.12 | pKi | 0.77 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis | B | 9.34 | pKi | 0.46 | nM | Ki | Bioorg Med Chem (2014) 22: 234-246 [PMID:24326276] |
ChEMBL | Displacement of [3H]CGP12177 from human beta2 adrenoceptor expressed in CHO cell membranes | B | 9.49 | pKi | 0.32 | nM | Ki | Bioorg Med Chem (2019) 27: 2959-2971 [PMID:31151791] |
GtoPdb | - | - | 9.5 | pKi | - | - | - |
Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Mol Pharmacol (1999) 56: 875-85 [PMID:10531390]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]; Mol Pharmacol (2003) 64: 679-88 [PMID:12920204] |
ChEMBL | Antagonist activity at human beta2 receptor expressed in CHO-K1 cells assessed as isoproterenol-induced cAMP level by HTRF assay | F | 7.3 | pIC50 | 50.12 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) | B | 8.95 | pIC50 | 1.12 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under dark conditions by FRET assay | F | 9.26 | pIC50 | 0.55 | nM | IC50 | J Med Chem (2020) 63: 8458-8470 [PMID:32686936] |
ChEMBL | Antagonist activity at ADRB2 endogenously expressed in HEK293 cells transfected with cAMP FRET biosensor assessed as inhibition of cimaterol-induced response pre-incubated for 45 mins under constant violet light conditions by FRET assay | F | 9.32 | pIC50 | 0.48 | nM | IC50 | J Med Chem (2020) 63: 8458-8470 [PMID:32686936] |
Beta-2 adrenergic receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2289] [UniProtKB: P54833] | ||||||||
ChEMBL | Compound was evaluated for competitive antagonism of beta-2 adrenergic receptor in rat uterus measured as pA2 (-log KB) | F | 8.75 | pKd | 1.78 | nM | Kd | J Med Chem (1984) 27: 857-861 [PMID:6330358] |
ChEMBL | Tested for Beta-2 adrenergic receptor selectivity in canine lung tissue in anesthetized dogs | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1990) 33: 2883-2891 [PMID:1976812] |
β2-adrenoceptor/Beta-2 adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3754] [GtoPdb: 29] [UniProtKB: P10608] | ||||||||
ChEMBL | Apparent dissociation constant towards beta-2 adrenergic receptor in rat lung membranes using (2-6)x10E-9M of [3AH]-DHA in the presence or absence of 10e-5 M (+/-) propranolol. | B | 9.4 | pKd | 0 | M | KD' | J Med Chem (1987) 30: 722-726 [PMID:3031293] |
Beta-2 adrenergic receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5414] [UniProtKB: Q8K4Z4] | ||||||||
ChEMBL | Inhibition of beta2-adrenergic receptor in guinea pig tracheal chain assessed as reversal of isoproterenol-induced effect after 15 mins | B | 6.62 | pKd | 240.88 | nM | Kd | J Med Chem (1978) 21: 68-72 [PMID:22756] |
ChEMBL | Antagonist activity of compound against Beta-2 adrenergic receptor in isolated guinea pig trachea | F | 7.36 | pKd | 43.65 | nM | Kd | J Med Chem (1981) 24: 994-998 [PMID:6120237] |
ChEMBL | Competitive antagonist activity at beta-2 adrenergic receptor in guinea pig assessed as inhibition of isoproterenol-induced tracheal relaxation | B | 7.83 | pKd | 14.79 | nM | Kd | J Med Chem (1979) 22: 210-214 [PMID:34040] |
ChEMBL | Beta-2 adrenergic receptor blocking activity in trachea of guinea pig. | B | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1984) 27: 1291-1294 [PMID:6148422] |
ChEMBL | The apparent pA2 value was measured for beta-2 adrenergic blocking activity on the trachea of guinea pig | F | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1980) 23: 620-624 [PMID:6104730] |
ChEMBL | Antagonism of isoprenaline-induced relaxation of guinea pig tracheal chains, contracted with carbachol | F | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1988) 31: 2122-2126 [PMID:2903245] |
ChEMBL | In vitro inhibitory activity against beta-2 adrenergic receptor determined as pA2 in guinea pig trachea | B | 8.47 | pKd | 3.39 | nM | Kd | J Med Chem (1985) 28: 896-900 [PMID:2861288] |
ChEMBL | In vitro beta-2 adrenergic receptor activity was determined by measuring inhibition of the isoproterenol induced relaxation in isolated guinea pig tracheal chains contracted with PGF2-alpha | B | 8.52 | pKd | 3.02 | nM | Kd | J Med Chem (1983) 26: 950-957 [PMID:6134834] |
ChEMBL | Antagonist activity at adrenergic beta2 receptor in isolated guinea pig trachea assessed as inhibition of isoprenaline-induced bronchodilation incubated for 20 mins | F | 8.57 | pKd | 2.69 | nM | Kd | Bioorg Med Chem (2018) 26: 3773-3784 [PMID:29706529] |
ChEMBL | Antagonist activity at beta2 adrenoceptor in guinea pig trachea assessed as inhibition of isoproterenol-induced response after 20 mins | B | 8.86 | pKd | 1.38 | nM | Kd | J Med Chem (1978) 21: 1081-1084 [PMID:31474] |
ChEMBL | Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation | B | 8.9 | pKd | 1.26 | nM | Kd | J Med Chem (1982) 25: 1408-1412 [PMID:6130154] |
ChEMBL | In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha contracted guinea pig trachea | B | 9.01 | pKd | 0.98 | nM | Kd | J Med Chem (1986) 29: 1065-1080 [PMID:2872332] |
ChEMBL | Inhibitory activity against beta-2 adrenergic receptor in guinea pig tracheal strip is determined | B | 7.54 | pIC50 | 28.84 | nM | IC50 | J Med Chem (1993) 36: 3077-3086 [PMID:8230093] |
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
ChEMBL | Displacement of [3H]-CGP 12177 from human beta-3 adrenergic receptor expressed in CHOK1 cells | B | 6.67 | pKd | 213.8 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | Antagonist activity at human beta-3 adrenergic receptor expressed in fenoterol-stimulated CHOK1 cells assessed as CRE-SPAP level by fluorescence correlation spectroscopic analysis | F | 6.79 | pKd | 162.18 | nM | Kd | J Med Chem (2011) 54: 6874-6887 [PMID:21870877] |
ChEMBL | DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) | B | 7 | pKi | 99 | nM | Ki | DrugMatrix in vitro pharmacology data |
GtoPdb | - | - | 7.2 | pKi | - | - | - |
Eur J Pharmacol (1999) 367: 431-5 [PMID:10079020]; Br J Pharmacol (2005) 144: 317-22 [PMID:15655528]; Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
ChEMBL | DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) | B | 6.88 | pIC50 | 132 | nM | IC50 | DrugMatrix in vitro pharmacology data |
β3-adrenoceptor in Mouse [GtoPdb: 30] [UniProtKB: P25962] | ||||||||
GtoPdb | - | - | 6.6 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
β3-adrenoceptor in Rat [GtoPdb: 30] [UniProtKB: P26255] | ||||||||
GtoPdb | - | - | 6.4 | pKi | - | - | - | Eur J Pharmacol (2004) 484: 323-31 [PMID:14744619] |
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] | ||||||||
ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells | F | 5.26 | pIC50 | 5500 | nM | IC50 | J Pharmacol Exp Ther (1999) 291: 1204-1209 [PMID:10565843] |
CCK1 receptor/Cholecystokinin A receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1901] [GtoPdb: 76] [UniProtKB: P32238] | ||||||||
ChEMBL | Antagonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as CCK8-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type CCKA receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.4 | pIC50 | 4000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.7 | pIC50 | 2000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Antagonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as DPDPE-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type opioid-delta 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
D1 receptor/Dopamine D1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2056] [GtoPdb: 214] [UniProtKB: P21728] | ||||||||
ChEMBL | Antagonist activity at human wild-type D1 receptor expressed in CHO cells assessed as dopamine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type D1 receptor expressed in CHO cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | Antagonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as dopamine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type D2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | Inhibitory constant against binding of [125I]- IBZM to D2 receptor in rat striatal membrane | B | 4.89 | pKi | 12902 | nM | Ki | J Med Chem (1988) 31: 1039-1043 [PMID:2966245] |
ChEMBL | Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1990) 33: 171-178 [PMID:2136916] |
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
ChEMBL | Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. | B | 5.3 | pKi | >5000 | nM | Ki | J Med Chem (1993) 36: 1499-1500 [PMID:8098771] |
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] | ||||||||
ChEMBL | Antagonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as endothelin-1-induced calcium by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type ETA receptor expressed in CHO-K1 cells assessed as calcium level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of hERG K channel | F | 5.55 | pIC50 | 2828 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Antagonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as U50488-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type opioid-kappa 1 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Antagonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as DAMGO-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type opioid-mu receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
ChEMBL | Antagonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type M1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
ChEMBL | Antagonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type M2 receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
ChEMBL | Antagonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as acetylcholine-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type M3 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
TLX/Nuclear receptor subfamily 2 group E member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1961788] [GtoPdb: 615] [UniProtKB: Q9Y466] | ||||||||
ChEMBL | Binding affinity to TLX LBD expressed in His6-tagged Escherichia coli Rosetta assessed as binding constant measured after 300 sec at 200 mM by isothermal titration calorimetry | B | 6.3 | pKd | 500 | nM | Kd | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
ChEMBL | Agonist activity at TAE expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as renilla luciferase reporter activity incubated for 14 hrs by Dual-glo luciferase | B | 4.43 | pEC50 | 37000 | nM | EC50 | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
ChEMBL | Agonist activity at in human TLX LBD expressed in human HEK293T cells coexpressing Gal4-VP 16 assessed as increase in reporter activity measured after 14 hrs by luciferase reporter gene assay relative to control | B | 4.49 | pEC50 | 32000 | nM | EC50 | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
ChEMBL | Agonist activity at full length TLX activating element expressed in human HEK293T cells coexpressing human full-length TLX/Gal4-VP 16 assessed as decrease in reporter activity at 100 uM by luciferase reporter gene assay relative to control | B | 4.49 | pEC50 | 32000 | nM | EC50 | J Med Chem (2021) 64: 8727-8738 [PMID:34115934] |
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
ChEMBL | High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model | B | 4.32 | pKi | 48000 | nM | Ki | J Med Chem (2002) 45: 5671-5686 [PMID:12477351] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 after 48 hrs by lactate dehydrogenase assay | F | 4.42 | pIC50 | 37680 | nM | IC50 | Bioorg Med Chem (2012) 20: 893-902 [PMID:22196513] |
ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by lactate dehydrogenase assay | F | 4.99 | pIC50 | 10190 | nM | IC50 | Bioorg Med Chem (2012) 20: 893-902 [PMID:22196513] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Antagonist activity at human 5-HT1A receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 6.86 | pKi | 139 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue of rat brain | B | 6.95 | pKi | 113 | nM | Ki | J Med Chem (1993) 36: 3161-3165 [PMID:8230102] |
ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1A receptor of rat hippocampal tissue using [3H]OH-DPAT as radioligand. | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (1989) 32: 859-863 [PMID:2539480] |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 6.61 | pIC50 | 243 | nM | IC50 | DrugMatrix in vitro pharmacology data |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
ChEMBL | Agonist activity to the human recombinant 5-hydroxytryptamine 1B receptor | F | 5 | pKi | >10000 | nM | Ki | J Med Chem (1997) 40: 4415-4419 [PMID:9435911] |
ChEMBL | Antagonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as seretonin-induced cAMP level by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human 5-HT1B receptor expressed in CHO-K1 cells assessed as cAMP level by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3459] [GtoPdb: 2] [UniProtKB: P28564] | ||||||||
ChEMBL | Inhibitory activity against 5-hydroxytryptamine 1B receptor of rat striatal membrane homogenate using [3H]5-HT as the radioligand. | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (1989) 32: 859-863 [PMID:2539480] |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | B | 6.38 | pKi | 419 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Antagonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) | B | 5.83 | pIC50 | 1466 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Agonist activity at human 5-HT2A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.66 | pKi | 218 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Antagonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.47 | pIC50 | 342 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Agonist activity at human 5-HT2B receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL225] [GtoPdb: 8] [UniProtKB: P28335] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | B | 5.92 | pKi | 1202 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Antagonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as seretonin-induced calcium level by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) | B | 5.64 | pIC50 | 2294 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Agonist activity at human 5-HT2C receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 5.85 | pKi | 1423 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Antagonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as seretonin-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 5.51 | pIC50 | 3065 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Agonist activity at human 5-HT6 receptor expressed in 1321N1 cells assessed as cAMP by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
5-HT7 receptor/Serotonin 7 (5-HT7) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3155] [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
ChEMBL | Antagonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as seretonin-induced cAMP by HTRF assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type 5-HT7 receptor expressed in HEK cells assessed as cAMP by HTRF assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
SERT/Serotonin transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL228] [GtoPdb: 928] [UniProtKB: P31645] | ||||||||
ChEMBL | DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) | B | 6.69 | pKi | 202 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) | B | 6.42 | pIC50 | 380 | nM | IC50 | DrugMatrix in vitro pharmacology data |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
ChEMBL | DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) | B | 5.92 | pKi | 1206 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) | B | 5.54 | pIC50 | 2870 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
ChEMBL | Inhibition of sodium current measured using whole-cell patch clamp experiments in HEK-293 cells stably transfected with hNaV1.5 cDNA | F | 5.68 | pIC50 | 2100 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.2 | pIC50 | 63200 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] | ||||||||
ChEMBL | Antagonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as angiotensin-2-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type AGTR1 receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
V1A receptor/Vasopressin V1a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1889] [GtoPdb: 366] [UniProtKB: P37288] | ||||||||
ChEMBL | Antagonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as vassopressin-induced calcium by FDSS assay | F | 5.3 | pIC50 | >5011.87 | nM | IC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
ChEMBL | Agonist activity at human wild-type AVPR1A receptor expressed in CHO-K1 cells assessed as calcium level by FDSS assay | F | 5.3 | pEC50 | >5011.87 | nM | EC50 | J Med Chem (2015) 58: 9287-9295 [PMID:26565745] |
Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
ChEMBL | Inhibition of calcium current (ICaL) measured using whole-cell patch clamp experiments in isolated guinea pig ventricular myocytes | F | 4.74 | pIC50 | 18000 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 4.74 | pIC50 | 18000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 4.68 | pIC50 | 21000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]