anandamide [Ligand Id: 2364] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL15848 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of Fatty-acid amide hydrolase (FAAH) activity in human lymphoma U937 cell using [3H]AEA as substrate in the 0-25 uM conc | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2002) 45: 3709-3720 [PMID:12166944] |
| ChEMBL | Inhibition of FAAH (unknown origin) | B | 5.39 | pIC50 | 4100 | nM | IC50 | J Med Chem (2018) 61: 5569-5579 [PMID:29856219] |
| ChEMBL | Inhibition of FAAH | B | 5.47 | pIC50 | 3400 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Binding affinity towards Fatty-acid amide hydrolase (FAAH) in rat forebrain membranes | B | 5.52 | pKi | 3000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1977-1980 [PMID:12781177] |
| ChEMBL | Inhibition of rat recombinant FAAH-mediated hydrolysis of [3H]AEA | B | 4.93 | pIC50 | 11748.98 | nM | IC50 | J Med Chem (2009) 52: 4613-4622 [PMID:19719235] |
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Binding affinity towards cloned human Cannabinoid receptor 1 | B | 1.95 | pKi | 1.95 | nM | Log Ki | J Med Chem (2000) 43: 2300-2309 [PMID:10882356] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with F3.25 (190)A mutant Cannabinoid receptor 1 | B | 5.74 | pKi | 1800 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with F3.36 (201)A mutant Cannabinoid receptor 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with W5 43(280)A mutant Cannabinoid receptor 1 at 5 uM | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with W6 48(357)A mutant in Cannabinoid receptor 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| ChEMBL | Ability to displace [3H]CP-55940 from the membranes prepared from HEK cell line with wild type Cannabinoid receptor 1 | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2003) 46: 5139-5152 [PMID:14613317] |
| GtoPdb | - | - | 7 | pKi | - | - | - |
Mol Pharmacol (1995) 48: 443-50 [PMID:7565624]; J Pharmacol Exp Ther (1996) 278: 989-99 [PMID:8819477] |
| ChEMBL | Binding affinity to human CB1 receptor in presence of serine protease inhibitor PMSF | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Binding affinity to CB1 receptor (unknown origin) | B | 7.05 | pKi | 89 | nM | Ki | Bioorg Med Chem (2016) 24: 5291-5301 [PMID:27624523] |
| ChEMBL | Displacement of [3H]-CP55940 from human recombinant CB1 receptor expressed in HEK cell membrane | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2020) 28: 115513-115513 [PMID:32340793] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB1 receptor | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 138-141 [PMID:16213718] |
| ChEMBL | Displacement of [3H]CP-55940 from human CB1 receptor expressed in COS cells | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2005) 48: 7343-7350 [PMID:16279794] |
| ChEMBL | Displacement of [3H]CP-55940 from human CB1 receptor expressed in HEK cells | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2007) 15: 5406-5416 [PMID:17561406] |
| ChEMBL | Binding affinity to human recombinant CB1 receptor expressed in african green monkey COS cells by radioligand binding assay | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2009) 52: 2506-2514 [PMID:19331413] |
| ChEMBL | Displacement of [3H]CP-55,940 from human recombinant CB1 receptor expressed in HEK293 cell membranes | B | 7.14 | pKi | 72 | nM | Ki | Bioorg Med Chem (2014) 22: 4770-4783 [PMID:25065940] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB1 receptor expressed in COS cells | B | 7.15 | pKi | 70 | nM | Ki | J Med Chem (2009) 52: 1005-1017 [PMID:19161308] |
| ChEMBL | Displacement of [3H]CP55940 from human CB1 receptor expressed in human HEK293 cells in presence of 100 nM PMSF | B | 7.15 | pKi | 70 | nM | Ki | J Med Chem (2011) 54: 8278-8288 [PMID:22044209] |
| ChEMBL | Binding affinity to human recombinant CB1 receptor expressed in COS cells | B | 7.15 | pKi | 70 | nM | Ki | J Med Chem (2006) 49: 2333-2338 [PMID:16570929] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB1 receptor in COS cells | B | 7.15 | pKi | 70 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 3765-3768 [PMID:16682198] |
| ChEMBL | Binding affinity for human cannabinoid receptor 1 | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
| ChEMBL | Binding affinity to CB1R (unknown origin) | B | 7.3 | pKi | 50 | nM | Ki | J Med Chem (2017) 60: 4-46 [PMID:27766867] |
| ChEMBL | Compound was evaluated for its binding affinity towards Cannabinoid receptor 1 [Inactive form(R) of CB1 receptor] | B | 7.41 | pKi | 39.2 | nM | Ki | J Med Chem (2002) 45: 3649-3659 [PMID:12166938] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cell membrane | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| CB1 receptor/Cannabinoid CB1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] | ||||||||
| ChEMBL | Binding affinity for Cannabinoid receptor 1 in absence of phenylmethylsulfonyl fluoride (PMSF) | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (1997) 40: 3617-3625 [PMID:9357528] |
| ChEMBL | Binding affinity for Cannabinoid receptor 1 in presence of phenylmethylsulfonyl fluoride (PMSF) | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (1997) 40: 3617-3625 [PMID:9357528] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3301-3303 [PMID:12951114] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with mouse brain membrane in the presence of PMSF | B | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3301-3303 [PMID:12951114] |
| ChEMBL | Agonist activity at CB1 receptor expressed in mouse brain membrane by [35S]GTPgammaS binding assay | F | 6.44 | pEC50 | 360 | nM | EC50 | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| CB1 receptor/Cannabinoid CB1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 5.24 | pKi | 5810 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | The compound was tested for Ki value against rat whole brain P2 membrane preparation in absence of enzyme inhibitor PMSF | B | 5.27 | pKi | 5400 | nM | Ki | J Med Chem (1999) 42: 1975-1981 [PMID:10354405] |
| ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| ChEMBL | Concentration required to displace 0.4 nM [3H]SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulfonyl fluoride | B | 6.1 | pKi | 800 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 447-449 [PMID:11229744] |
| ChEMBL | Displacement of [3H]SR141716A from CB1 receptor in CD rat brain membranes | B | 6.4 | pKi | 400 | nM | Ki | J Nat Prod (2003) 66: 1364-1368 [PMID:14575438] |
| ChEMBL | Binding affinity to CB1 cannabinoid receptor using [3H]WIN-55212-2 in rat cerebellum membranes | B | 6.55 | pKi | 285 | nM | Ki | J Med Chem (2001) 44: 4505-4508 [PMID:11741470] |
| ChEMBL | Displacement of [3H]SR141716A from CB1 receptor in rat cerebellar membrane after 90 mins by scintillation counting | B | 6.88 | pKi | 132 | nM | Ki | Eur J Med Chem (2009) 44: 4889-4895 [PMID:19762126] |
| ChEMBL | Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 1 in the presence of PMSF | B | 7.05 | pKi | 90 | nM | Ki | J Med Chem (2002) 45: 3709-3720 [PMID:12166944] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 in rat forebrain membranes using [3H]CP-55940 as radioligand | B | 7.05 | pKi | 90 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1977-1980 [PMID:12781177] |
| ChEMBL | The compound was tested for Ki value against rat whole brain P2 membrane preparation in presence of enzyme inhibitor PMSF. | B | 7.05 | pKi | 89 | nM | Ki | J Med Chem (1999) 42: 1975-1981 [PMID:10354405] |
| ChEMBL | Displacement of [3H]CP55940 from CB1 receptor in Wistar rat brain incubated for 60 mins by radioactive filter binding assay | B | 7.05 | pKi | 89 | nM | Ki | Eur J Med Chem (2016) 112: 66-80 [PMID:26890113] |
| ChEMBL | Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranes | B | 7.11 | pKi | 78 | nM | Ki | J Med Chem (1996) 39: 4515-4519 [PMID:8893848] |
| ChEMBL | Tested for binding affinity to Cannabinoid receptor 1 | B | 7.11 | pKi | 78 | nM | Ki | J Med Chem (1999) 42: 896-902 [PMID:10072686] |
| ChEMBL | Displacement of [3H]CP-55,940 from CB1 receptor in rat brain membranes in presence of FAAH inhibitor PMSF by radioligand binding assay | B | 7.13 | pKi | 74 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| ChEMBL | Binding affinity for cannabinoid receptor 1 | B | 7.14 | pKi | 72 | nM | Ki | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
| ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | In vitro binding affinity was determined against rat brain Cannabinoid receptor 1 | B | 7.41 | pKi | 39.2 | nM | Ki | J Med Chem (1997) 40: 659-667 [PMID:9057852] |
| ChEMBL | Displacement of [3H]CP-55940 binding to Cannabinoid receptor 1 in rat brain membranes | B | 7.66 | pKi | 22 | nM | Ki | J Med Chem (1998) 41: 4207-4215 [PMID:9784095] |
| ChEMBL | Binding affinity towards Cannabinoid receptor 1 was determined using [3H]-CP- cannabinoid as radioligand with rat brain membrane in the presence of PMSF | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 3301-3303 [PMID:12951114] |
| ChEMBL | Cannabinoid receptor 1 dependent activity of compound was evaluated by using [35S]GTP-gamma-S-binding studies | F | 4.8 | pEC50 | 15848.93 | nM | EC50 | Bioorg Med Chem Lett (2004) 14: 3231-3234 [PMID:15149681] |
| ChEMBL | Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor | F | 4.8 | pEC50 | 15848.93 | nM | EC50 | J Med Chem (2006) 49: 554-566 [PMID:16420041] |
| ChEMBL | Agonist activity at rat CB1 receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins | F | 7.16 | pEC50 | 69 | nM | EC50 | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Binding affinity towards cloned human cannabinoid receptor 2 | B | 2.57 | pKi | 2.57 | nM | Log Ki | J Med Chem (2000) 43: 2300-2309 [PMID:10882356] |
| ChEMBL | Binding affinity to human CB2 cannabinoid receptor using [3H]CP-55940 in HEK293 EBNA transfected cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2001) 44: 4505-4508 [PMID:11741470] |
| GtoPdb | - | - | 6.4 | pKi | - | - | - |
Mol Pharmacol (1995) 48: 443-50 [PMID:7565624]; J Pharmacol Exp Ther (1996) 278: 989-99 [PMID:8819477]; Biochem Pharmacol (1995) 50: 83-90 [PMID:7605349] |
| ChEMBL | Binding affinity to CB2 receptor (unknown origin) | B | 6.43 | pKi | 371 | nM | Ki | Bioorg Med Chem (2016) 24: 5291-5301 [PMID:27624523] |
| ChEMBL | Binding affinity to human CB2 receptor in presence of serine protease inhibitor PMSF | B | 6.43 | pKi | 371 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB2 receptor in COS cells | B | 6.74 | pKi | 180 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 3765-3768 [PMID:16682198] |
| ChEMBL | Displacement of [3H]CP-55-940 from human recombinant CB2 receptor expressed in COS cells | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2009) 52: 1005-1017 [PMID:19161308] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB2 receptor | B | 6.74 | pKi | 180 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 138-141 [PMID:16213718] |
| ChEMBL | Binding affinity to human recombinant CB2 receptor expressed in COS cells | B | 6.74 | pKi | 180 | nM | Ki | J Med Chem (2006) 49: 2333-2338 [PMID:16570929] |
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cell membrane | B | 6.77 | pKi | 168 | nM | Ki | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| ChEMBL | Displacement of [3H]CP-55,940 from human CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6.8 | pKi | 160 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| CB2 receptor/Cannabinoid CB2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| ChEMBL | Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]CP-55940 as radioligand | B | 5.71 | pKi | 1930 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | Compound was evaluated for its binding affinity for mouse spleen Cannabinoid receptor 2 | B | 5.72 | pKi | 1926 | nM | Ki | J Med Chem (1996) 39: 4515-4519 [PMID:8893848] |
| ChEMBL | Displacement of [3H]CP-55,940 from mouse CB2 receptor expressed in HEK293 cell membranes in absence of FAAH inhibitor PMSF by radioligand binding assay | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2018) 61: 8639-8657 [PMID:30196704] |
| CB2 receptor/Cannabinoid CB2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9] | ||||||||
| ChEMBL | Displacement of [3H]CP-55940 from rat forebrain membrane which expresses Cannabinoid receptor 2 in the presence of PMSF | B | 6.44 | pKi | 360 | nM | Ki | J Med Chem (2002) 45: 3709-3720 [PMID:12166944] |
| Potassium channel subfamily K member 2 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075183] [UniProtKB: Q8HY88] | ||||||||
| ChEMBL | Activation of bovine TREK1 expressed in AZT cells assessed as reduction in channel currents | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2016) 59: 5149-5157 [PMID:26588045] |
| K2P3.1/Potassium channel subfamily K member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321613] [GtoPdb: 515] [UniProtKB: O14649] | ||||||||
| ChEMBL | Inhibition of human TASK1 expressed in African green monkey COS7 cells by whole cell patch clamp assay | B | 5.52 | pIC50 | 3000 | nM | IC50 | J Med Chem (2019) 62: 10044-10058 [PMID:31260312] |
| GtoPdb | - | - | 5.6 | pIC50 | 2700 | nM | IC50 | EMBO J (2001) 20: 47-54 [PMID:11226154] |
| GtoPdb | - | - | 6.15 | pIC50 | ~700 | nM | IC50 | EMBO J (2001) 20: 47-54 [PMID:11226154] |
| TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5.07 | pIC50 | 8600 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 6.02 | pIC50 | 960 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
| TRPV1/Vanilloid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4794] [GtoPdb: 507] [UniProtKB: Q8NER1] | ||||||||
| GtoPdb | - | - | 5 | pEC50 | - | - | - | J Biol Chem (2003) 278: 30429-34 [PMID:12761211] |
| GtoPdb | - | - | 5.9 | pEC50 | - | - | - | Br J Pharmacol (2000) 129: 227-30 [PMID:10694225] |
| ChEMBL | Activation of human VR1 expressed in HEK293 cells assessed as stimulation of Ca2+ influx | B | 6.2 | pEC50 | 630 | nM | EC50 | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| ChEMBL | Agonist activity on human recombinant TRPV1-mediated enhancement of intracellular calcium concentration in HEK293 cells | F | 6.31 | pEC50 | 490 | nM | EC50 | J Med Chem (2006) 49: 2333-2338 [PMID:16570929] |
| ChEMBL | Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level | F | 6.7 | pEC50 | 200 | nM | EC50 | J Med Chem (2009) 52: 3001-3009 [PMID:19361197] |
| ChEMBL | Agonist activity at TRPV1 receptor (unknown origin) | B | 7.8 | pEC50 | 15.8 | nM | EC50 | J Med Chem (2013) 56: 1811-1829 [PMID:23384387] |
| TRPV1/Vanilloid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5102] [GtoPdb: 507] [UniProtKB: O35433] | ||||||||
| ChEMBL | Binding affinity to vanilloid VR1 receptor using [3H]resiniferatoxin ([3H]-RTX) in rat spinal cord membranes | B | 6.77 | pKi | 169 | nM | Ki | J Med Chem (2001) 44: 4505-4508 [PMID:11741470] |
| GtoPdb | - | - | 5.3 | pEC50 | - | - | - | Nature (1999) 400: 452-7 [PMID:10440374] |
| GPR18 in Human [GtoPdb: 89] [UniProtKB: Q14330] | ||||||||
| GtoPdb | - | - | 5.42 | pEC50 | 3830 | nM | EC50 | Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653] |
| GPR55 in Human [GtoPdb: 109] [UniProtKB: Q9Y2T6] | ||||||||
| GtoPdb | - | - | 7.74 | pEC50 | 18 | nM | EC50 | Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302] |
| glycine receptor α1 subunit in Human [GtoPdb: 423] [UniProtKB: P23415] | ||||||||
| GtoPdb | - | - | 7.4 | pEC50 | 38 | nM | EC50 | |
| Cav3.1 in Human [GtoPdb: 535] [UniProtKB: O43497] | ||||||||
| GtoPdb | - | - | 5.4 | pIC50 | - | - | - | EMBO J (2001) 20: 7033-40 [PMID:11742980] |
| Cav3.2 in Human [GtoPdb: 536] [UniProtKB: O95180] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | EMBO J (2001) 20: 7033-40 [PMID:11742980] |
| Cav3.3 in Human [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
| GtoPdb | - | - | 6 | pIC50 | - | - | - | EMBO J (2001) 20: 7033-40 [PMID:11742980] |
| Kv1.2 in Human [GtoPdb: 539] [UniProtKB: P16389] | ||||||||
| GtoPdb | - | - | 5.6 | pIC50 | 2700 | nM | IC50 | Neuropharmacology (1996) 35: 983-91 [PMID:8938728] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
