compound 12c [PMID: 16516466] | Ligand Activity Charts

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compound 12c [PMID: 16516466]
Ligand Activity Charts

compound 12c [PMID: 16516466] [Ligand Id: 8663] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL208009
MMP2/72 kDa type IV collagenase in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] There should be some charts here, you may need to enable JavaScript!
ADAMTS1/A disintegrin and metalloproteinase with thrombospondin motifs 1 in Human [ChEMBL: CHEMBL5133] [GtoPdb: 1674] [UniProtKB: Q9UHI8] There should be some charts here, you may need to enable JavaScript!
ADAMTS4/A disintegrin and metalloproteinase with thrombospondin motifs 4 in Human [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173] There should be some charts here, you may need to enable JavaScript!
ADAMTS5/A disintegrin and metalloproteinase with thrombospondin motifs 5 in Human [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0] There should be some charts here, you may need to enable JavaScript!
MMP13/Collagenase 3 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] There should be some charts here, you may need to enable JavaScript!
ADAM17/Disintegrin and metalloproteinase domain-containing protein 17 in Human [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] Disintegrin and metalloproteinase domain-containing protein 17 in Pig [ChEMBL: CHEMBL3332] [UniProtKB: O77636] There should be some charts here, you may need to enable JavaScript!
MMP1/Interstitial collagenase in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] There should be some charts here, you may need to enable JavaScript!
MMP7/Matrilysin in Human [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] There should be some charts here, you may need to enable JavaScript!
MMP14/Matrix metalloproteinase-14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] There should be some charts here, you may need to enable JavaScript!
MMP15/Matrix metalloproteinase-15 in Human [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511] There should be some charts here, you may need to enable JavaScript!
MMP16/Matrix metalloproteinase-16 in Human [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] There should be some charts here, you may need to enable JavaScript!
MMP9/Matrix metalloproteinase-9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] There should be some charts here, you may need to enable JavaScript!
MMP8/Neutrophil collagenase in Human [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] There should be some charts here, you may need to enable JavaScript!
MMP3/Stromelysin-1 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MMP2/72 kDa type IV collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL	Binding affinity to MMP2	B	5.48	pKi	>3333	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
ADAMTS1/A disintegrin and metalloproteinase with thrombospondin motifs 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5133] [GtoPdb: 1674] [UniProtKB: Q9UHI8]
GtoPdb	-	-	6.11	pKi	776	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-704 [PMID:16516466]
ChEMBL	Binding affinity to ADAMTS1	B	6.11	pKi	776	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
ADAMTS4/A disintegrin and metalloproteinase with thrombospondin motifs 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173]
ChEMBL	Binding affinity to ADAMTS4	B	5.74	pKi	1834	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
ADAMTS5/A disintegrin and metalloproteinase with thrombospondin motifs 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0]
ChEMBL	Binding affinity to ADAMTS5	B	7.01	pKi	97	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP13/Collagenase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL	Binding affinity to MMP13	B	5.3	pKi	>5025	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
ADAM17/Disintegrin and metalloproteinase domain-containing protein 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL	Inhibition of LPS-stimulated TNFalpha production in human whole blood	F	7.44	pIC50	36	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
Disintegrin and metalloproteinase domain-containing protein 17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636]
ChEMBL	Inhibition of porcine TACE	B	8.72	pIC50	1.9	nM	IC50	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP1/Interstitial collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL	Binding affinity to MMP1	B	5.31	pKi	>4949	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP7/Matrilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL	Binding affinity to MMP7	B	7.74	pKi	18	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP14/Matrix metalloproteinase-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL	Binding affinity to MMP14	B	5.28	pKi	>5290	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP15/Matrix metalloproteinase-15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511]
ChEMBL	Binding affinity to MMP15	B	5.15	pKi	>7088	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP16/Matrix metalloproteinase-16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512]
ChEMBL	Binding affinity to MMP16	B	5.26	pKi	>5554	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP9/Matrix metalloproteinase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL	Binding affinity to MMP9	B	5.67	pKi	>2128	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP8/Neutrophil collagenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL	Binding affinity to MMP8	B	6.66	pKi	217	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]
MMP3/Stromelysin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL	Binding affinity to MMP3	B	7.04	pKi	91	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]