compound 12c [PMID: 16516466] [Ligand Id: 8663] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL208009 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of LPS-stimulated TNFalpha production in human whole blood | F | 7.44 | pIC50 | 36 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAM17 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3332] [UniProtKB: O77636] | ||||||||
| ChEMBL | Inhibition of porcine TACE | B | 8.72 | pIC50 | 1.9 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAMTS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5133] [GtoPdb: 1674] [UniProtKB: Q9UHI8] | ||||||||
| GtoPdb | - | - | 6.11 | pKi | 776 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-704 [PMID:16516466] |
| ChEMBL | Binding affinity to ADAMTS1 | B | 6.11 | pKi | 776 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAMTS4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2318] [GtoPdb: 1677] [UniProtKB: O75173] | ||||||||
| ChEMBL | Binding affinity to ADAMTS4 | B | 5.74 | pKi | 1834 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| ADAMTS5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2285] [GtoPdb: 1678] [UniProtKB: Q9UNA0] | ||||||||
| ChEMBL | Binding affinity to ADAMTS5 | B | 7.01 | pKi | 97 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Binding affinity to MMP1 | B | 5.31 | pKi | >4949 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Binding affinity to MMP13 | B | 5.3 | pKi | >5025 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Binding affinity to MMP14 | B | 5.28 | pKi | >5290 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP15/Matrix metalloproteinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2963] [GtoPdb: 1639] [UniProtKB: P51511] | ||||||||
| ChEMBL | Binding affinity to MMP15 | B | 5.15 | pKi | >7088 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP16/Matrix metalloproteinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2200] [GtoPdb: 1640] [UniProtKB: P51512] | ||||||||
| ChEMBL | Binding affinity to MMP16 | B | 5.26 | pKi | >5554 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Binding affinity to MMP2 | B | 5.48 | pKi | >3333 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Binding affinity to MMP3 | B | 7.04 | pKi | 91 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Binding affinity to MMP7 | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Binding affinity to MMP8 | B | 6.66 | pKi | 217 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Binding affinity to MMP9 | B | 5.67 | pKi | >2128 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2699-2704 [PMID:16516466] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
