ChEMBL ligand: CHEMBL518924 (Amd 070, AMD-070, AMD070, AMD-11070, AMD11070, Cxcr4 inhibitor x4p-001, Mavorixafor, X4p001, X 4P-001, X4P-001)
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] There should be some charts here, you may need to enable JavaScript!
CCR1/C-C chemokine receptor type 1 in Human [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246] There should be some charts here, you may need to enable JavaScript!
CCR2/C-C chemokine receptor type 2 in Human [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597] There should be some charts here, you may need to enable JavaScript!
CCR4/C-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679] There should be some charts here, you may need to enable JavaScript!
CCR5/C-C chemokine receptor type 5 in Human [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681] There should be some charts here, you may need to enable JavaScript!
CXCR4/C-X-C chemokine receptor type 4 in Human [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073] There should be some charts here, you may need to enable JavaScript!
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
CXCR1/Interleukin-8 receptor A in Human [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024] There should be some charts here, you may need to enable JavaScript!
CXCR2/Interleukin-8 receptor B in Human [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL	Inhibition of alpha 2A adrenergic receptor (unknown origin)	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
CCR1/C-C chemokine receptor type 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2413] [GtoPdb: 58] [UniProtKB: P32246]
ChEMBL	Displacement of radiolabeled MIP1alpha from CCR1 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CCR2/C-C chemokine receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4015] [GtoPdb: 59] [UniProtKB: P41597]
ChEMBL	Displacement of radiolabeled MCP1 from CCR2b receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CCR4/C-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2414] [GtoPdb: 61] [UniProtKB: P51679]
ChEMBL	Displacement of radiolabeled TARC from CCR4 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CCR5/C-C chemokine receptor type 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL274] [GtoPdb: 62] [UniProtKB: P51681]
ChEMBL	Displacement of radiolabeled MIP1beta from CCR5 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CXCR4/C-X-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073]
ChEMBL	Binding affinity to CXCR4 (unknown origin) assessed as inhibition constant	B	7.64	pKi	23	nM	Ki	J Med Chem (2017) 60: 4735-4779 [PMID:28165741]
GtoPdb	Assay using 125I-SDF-1α as tracer, in Cf2Th cells expressing hCXCR4.	-	7.96	pKi	11	nM	Ki	Mol Pharmacol (2008) 74: 1485-95 [PMID:18768385]
ChEMBL	Antagonist activity at CXCR4 in human PBMC assessed as inhibition of HIV-1 3B infection	B	7.52	pIC50	30	nM	IC50	ACS Med Chem Lett (2013) 4: 1025-1030 [PMID:24936240]
ChEMBL	Displacement of [125I]SDF-1-alpha from CXCR4 in human CEM-CCRF cells by liquid scintillation counting	B	7.89	pIC50	13	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
GtoPdb	Displacement of [125I]SDF-1α binding from CXCR4 in human CEM-CCRF cells by liquid scintillation counting.	-	7.89	pIC50	13	nM	IC50	J Med Chem (2010) 53: 3376-88 [PMID:20297846]
ChEMBL	Antagonist activity at CXCR4 receptor in human CCRF-CEM cells assessed as inhibition of SDF-1alpha-induced calcium release preincubated for 25 mins followed by SDF-1alpha addition and monitered for 90 sec	F	8.29	pIC50	5.18	nM	IC50	ACS Med Chem Lett (2021) 12: 1605-1612 [PMID:34676043]
ChEMBL	Antagonist activity at CXCR4 in human CCRF-CEM cells assessed as inhibition of SDS1alpha-induced calcium flux pretreated for 25 mins followed by SDS1alpha addition measured for 90 secs by calcium-dye based assay	F	8.3	pIC50	5	nM	IC50	ACS Med Chem Lett (2018) 9: 446-451 [PMID:29795757]
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Inhibition of dopamine D2 receptor (unknown origin)	B	5.39	pIC50	4100	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
CXCR1/Interleukin-8 receptor A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4029] [GtoPdb: 68] [UniProtKB: P25024]
ChEMBL	Displacement of radiolabeled IL8 from CXCR1 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
CXCR2/Interleukin-8 receptor B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2434] [GtoPdb: 69] [UniProtKB: P25025]
ChEMBL	Displacement of radiolabeled IL8 from CXCR2 receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (2010) 53: 3376-3388 [PMID:20297846]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Inhibition of kappa opioid receptor (unknown origin)	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Inhibition of mu opioid receptor (unknown origin)	B	4.92	pIC50	12000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Inhibition of M2 mAChR receptor (unknown origin)	B	5.12	pIC50	7500	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]
nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544]
ChEMBL	Inhibition of alpha7 nicotinic acetylcholine receptor (unknown origin)	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2022) 65: 4058-4084 [PMID:35179893]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]