leucettine L41 [Ligand Id: 8167] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1802358
  • phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Mouse [ChEMBL: CHEMBL2176842] [GtoPdb: 2857] [UniProtKB: Q9Z1T6]
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Mouse [ChEMBL: CHEMBL3537] [GtoPdb: 1549] [UniProtKB: Q60737]
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  • casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Mouse [ChEMBL: CHEMBL5326] [GtoPdb: 1550] [UniProtKB: O54833]
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  • casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Mouse [ChEMBL: CHEMBL4095] [GtoPdb: 1551] [UniProtKB: P67871]
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
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  • CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518]
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  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492]
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  • CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
  • CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Mouse [ChEMBL: CHEMBL4750] [GtoPdb: 2009] [UniProtKB: Q61214]
  • dual specificity tyrosine phosphorylation regulated kinase 1A in Rat [GtoPdb: 2009] [UniProtKB: Q63470]
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  • dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
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  • dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
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  • dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781]
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  • dual specificity tyrosine phosphorylation regulated kinase 4/Dual specificity tyrosine-phosphorylation-regulated kinase 4 in Human [ChEMBL: CHEMBL1075115] [GtoPdb: 2013] [UniProtKB: Q9NR20]
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  • CDC like kinase 1/Dual specificty protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
  • CDC like kinase 1 in Mouse [GtoPdb: 1990] [UniProtKB: P22518]
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  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
  • glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Mouse [ChEMBL: CHEMBL2176843] [GtoPdb: 2029] [UniProtKB: Q2NL51]
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  • glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
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  • homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02]
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  • homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
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  • interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
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  • mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Rat [ChEMBL: CHEMBL5233] [GtoPdb: 1495] [UniProtKB: P63086]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
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  • STE20 like kinase/STE20-like serine/threonine-protein kinase in Mouse [ChEMBL: CHEMBL2176844] [GtoPdb: 2200] [UniProtKB: O54988]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176842] [GtoPdb: 2857] [UniProtKB: Q9Z1T6]
ChEMBL Binding affinity to phosphatidylinositol-3-phosphate 5-kinase type 3 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis B 5.22 pKd 6010 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of human recombinant CK2 using RRREDEESDDEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 6.49 pIC50 320 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3537] [GtoPdb: 1549] [UniProtKB: Q60737]
ChEMBL Binding affinity to CSNK2A1 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis B 6.49 pKd 326 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5326] [GtoPdb: 1550] [UniProtKB: O54833]
ChEMBL Binding affinity to CSNK2A2 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis B 6.24 pKd 574 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4095] [GtoPdb: 1551] [UniProtKB: P67871]
ChEMBL Binding affinity to CSNK2N in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis B 6.42 pKd 382 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
cyclin dependent kinase 2/CDK2/Cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248P24941]
ChEMBL Inhibition of human recombinant CDK2/cyclin A using [gamma-33P]-ATP after 30 mins by scintillation counting B 5 pIC50 >10000 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563P50750]
ChEMBL Inhibition of human recombinant CDK9/cyclin T expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 4.74 pIC50 18000 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant CDK9/cyclin T using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate B 5 pIC50 >10000 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248P24941P78396]
ChEMBL Inhibition of CDK2/cyclin A using [gamma33P]ATP after 30 mins by scintillation counting B 4.52 pIC50 >30000 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 4.52 pIC50 >30000 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant CDK5/p25 using [gamma-33P]-ATP after 30 mins by scintillation counting B 5 pIC50 >10000 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
ChEMBL Inhibition of human recombinant CDK5/p25 B 6.39 pIC50 410 nM IC50 J. Med. Chem. (2011) 54: 4172-4186 [PMID:21615147]
cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613P51946]
ChEMBL Inhibition of human recombinant CDK7/cyclin H expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518]
ChEMBL Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.15 pIC50 71 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 7.46 pIC50 35 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
ChEMBL Inhibition of mouse recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate B 7.82 pIC50 15 nM IC50 J. Med. Chem. (2011) 54: 4172-4186 [PMID:21615147]
GtoPdb - - 10.82 pIC50 0.01 nM IC50 J Med Chem (2011) 54: 4172-86 [PMID:21615147]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Binding affinity to CLK2 B 6.44 pKd 360 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491]
ChEMBL Inhibition of mouse recombinant GST-tagged CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 6.14 pIC50 720 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 6.49 pIC50 320 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Binding affinity to CLK3 B 5.96 pKd 1100 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492]
ChEMBL Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrate B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2011) 54: 4172-4186 [PMID:21615147]
ChEMBL Inhibition of mouse recombinant GST-tagged CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 5 pIC50 >10000 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 5.52 pIC50 3000 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
GtoPdb - - 8.35 pIC50 4.5 nM IC50 J Med Chem (2011) 54: 4172-86 [PMID:21615147]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL Binding affinity to CLK4 B 7.15 pKd 70 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493]
ChEMBL Inhibition of mouse recombinant GST-tagged CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.19 pIC50 64 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 7.51 pIC50 31 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
ChEMBL Inhibition of rat recombinant GST-tagged DYRK1A using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting B 7.4 pIC50 40 nM IC50 J. Med. Chem. (2011) 54: 4172-4186 [PMID:21615147]
ChEMBL Inhibition of rat recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.4 pIC50 40 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of rat DYRK1A isolated from brain using KKISGRLSPIMTEQ as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 8 pIC50 10 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
GtoPdb - - 10.4 pIC50 0.04 nM IC50 J Med Chem (2011) 54: 4172-86 [PMID:21615147]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Binding affinity to DYRK1A B 8.11 pKd 7.8 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant full length GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.22 pIC50 60 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.26 pIC50 55 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of DYRK1A (unknown origin) B 7.26 pIC50 55 nM IC50 J Med Chem (2017) 60: 2052-2070 [PMID:28206758]
ChEMBL Inhibition of human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 7.68 pIC50 21 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4750] [GtoPdb: 2009] [UniProtKB: Q61214]
ChEMBL Binding affinity to DYRK1A in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis B 7.19 pKd 65 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
dual specificity tyrosine phosphorylation regulated kinase 1A in Rat [GtoPdb: 2009] [UniProtKB: Q63470]
GtoPdb - - 10.4 pIC50 0.04 nM IC50 J Med Chem (2011) 54: 4172-86 [PMID:21615147]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
ChEMBL Binding affinity to DYRK1B B 6.85 pKd 140 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 7.11 pIC50 77 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
ChEMBL Inhibition of human recombinant GST-tagged DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.36 pIC50 44 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL Binding affinity to DYRK2 B 6.35 pKd 450 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 6.66 pIC50 220 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
ChEMBL Inhibition of human recombinant GST-tagged DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 7.14 pIC50 73 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of human recombinant GST-tagged DYRK2 using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting B 7.46 pIC50 35 nM IC50 J. Med. Chem. (2011) 54: 4172-4186 [PMID:21615147]
GtoPdb - - 9.46 pIC50 0.35 nM IC50 J Med Chem (2011) 54: 4172-86 [PMID:21615147]
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781]
ChEMBL Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate B 6.15 pIC50 700 nM IC50 Eur. J. Med. Chem. (2013) 62: 728-737 [PMID:23454515]
ChEMBL Inhibition of human recombinant GST-tagged DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 6.49 pIC50 320 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
dual specificity tyrosine phosphorylation regulated kinase 4/Dual specificity tyrosine-phosphorylation-regulated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075115] [GtoPdb: 2013] [UniProtKB: Q9NR20]
GtoPdb - - 6.28 pIC50 520 nM IC50 J Med Chem (2012) 55: 9312-30 [PMID:22998443]
ChEMBL Inhibition of human recombinant GST-tagged DYRK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting B 6.28 pIC50 520 nM IC50 J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL Binding affinity to CLK1 B 7.12 pKd 75 nM Kd J. Med. Chem. (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL Inhibition of CLK1 (unknown origin) B 7.15 pIC50 71 nM IC50 J Med Chem (2017) 60: 2052-2070 [PMID:28206758]
CDC like kinase 1 in Mouse [GtoPdb: 1990] [UniProtKB: P22518]
GtoPdb - - 10.82 pIC50 0.01 nM IC50 J Med Chem (2011) 54: 4172-86 [PMID:21615147]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL Binding affinity to GSK3A B 6.26