ChEMBL ligand: CHEMBL1802358
phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Mouse [ChEMBL: CHEMBL2176842] [GtoPdb: 2857] [UniProtKB: Q9Z1T6] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Mouse [ChEMBL: CHEMBL3537] [GtoPdb: 1549] [UniProtKB: Q60737] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Mouse [ChEMBL: CHEMBL5326] [GtoPdb: 1550] [UniProtKB: O54833] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Mouse [ChEMBL: CHEMBL4095] [GtoPdb: 1551] [UniProtKB: P67871] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/CDK2/Cyclin A in Human [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 9/CDK9/cyclin T1 in Human [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613, P51946] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Mouse [ChEMBL: CHEMBL4750] [GtoPdb: 2009] [UniProtKB: Q61214] dual specificity tyrosine phosphorylation regulated kinase 1A in Rat [GtoPdb: 2009] [UniProtKB: Q63470] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] There should be some charts here, you may need to enable JavaScript!
dual specificity tyrosine phosphorylation regulated kinase 4/Dual specificity tyrosine-phosphorylation-regulated kinase 4 in Human [ChEMBL: CHEMBL1075115] [GtoPdb: 2013] [UniProtKB: Q9NR20] There should be some charts here, you may need to enable JavaScript!
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] CDC like kinase 1 in Mouse [GtoPdb: 1990] [UniProtKB: P22518] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Mouse [ChEMBL: CHEMBL2176843] [GtoPdb: 2029] [UniProtKB: Q2NL51] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02] There should be some charts here, you may need to enable JavaScript!
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422] There should be some charts here, you may need to enable JavaScript!
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Rat [ChEMBL: CHEMBL5233] [GtoPdb: 1495] [UniProtKB: P63086] There should be some charts here, you may need to enable JavaScript!
Protein VAC14 homolog in Mouse [ChEMBL: CHEMBL2176841] [UniProtKB: Q80WQ2] There should be some charts here, you may need to enable JavaScript!
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] There should be some charts here, you may need to enable JavaScript!
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] There should be some charts here, you may need to enable JavaScript!
STE20 like kinase/STE20-like serine/threonine-protein kinase in Mouse [ChEMBL: CHEMBL2176844] [GtoPdb: 2200] [UniProtKB: O54988] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphoinositide kinase, FYVE-type zinc finger containing/1-phosphatidylinositol 3-phosphate 5-kinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176842] [GtoPdb: 2857] [UniProtKB: Q9Z1T6]
ChEMBL	Binding affinity to phosphatidylinositol-3-phosphate 5-kinase type 3 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	5.22	pKd	6010	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Inhibition of human recombinant CK2 using RRREDEESDDEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.49	pIC50	320	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3537] [GtoPdb: 1549] [UniProtKB: Q60737]
ChEMBL	Binding affinity to CSNK2A1 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	6.49	pKd	326	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5326] [GtoPdb: 1550] [UniProtKB: O54833]
ChEMBL	Binding affinity to CSNK2A2 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	6.24	pKd	574	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4095] [GtoPdb: 1551] [UniProtKB: P67871]
ChEMBL	Binding affinity to CSNK2N in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	6.42	pKd	382	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
cyclin dependent kinase 2/CDK2/Cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038469] [GtoPdb: 1973] [UniProtKB: P20248, P24941]
ChEMBL	Inhibition of human recombinant CDK2/cyclin A using [gamma-33P]-ATP after 30 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
cyclin dependent kinase 9/CDK9/cyclin T1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111389] [GtoPdb: 1981] [UniProtKB: O60563, P50750]
ChEMBL	Inhibition of human recombinant CDK9/cyclin T expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	4.74	pIC50	18000	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant CDK9/cyclin T using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094128] [GtoPdb: 1973] [UniProtKB: P20248, P24941, P78396]
ChEMBL	Inhibition of CDK2/cyclin A using [gamma33P]ATP after 30 mins by scintillation counting	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
ChEMBL	Inhibition of human recombinant CDK5/p25 using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant CDK5/p25 using [gamma-33P]-ATP after 30 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
ChEMBL	Inhibition of human recombinant CDK5/p25	B	6.39	pIC50	410	nM	IC50	J Med Chem (2011) 54: 4172-4186 [PMID:21615147]
cyclin dependent kinase 7/Cyclin-dependent kinase 7/ cyclin H in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111288] [GtoPdb: 1979] [UniProtKB: P50613, P51946]
ChEMBL	Inhibition of human recombinant CDK7/cyclin H expressed in insect cell using YSPTSPSYSPTSPSYSPTSPSKKKK as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 1/Dual specificity protein kinase CLK1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075280] [GtoPdb: 1990] [UniProtKB: P22518]
ChEMBL	Inhibition of mouse recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.15	pIC50	71	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of mouse recombinant CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.46	pIC50	35	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
ChEMBL	Inhibition of mouse recombinant GST-tagged CLK1 using GRSRSRSRSRSR as substrate	B	7.82	pIC50	15	nM	IC50	J Med Chem (2011) 54: 4172-4186 [PMID:21615147]
GtoPdb	-	-	10.82	pIC50	0.01	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL	Binding affinity to CLK2	B	6.44	pKd	360	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075281] [GtoPdb: 1991] [UniProtKB: O35491]
ChEMBL	Inhibition of mouse recombinant GST-tagged CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.14	pIC50	720	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of mouse recombinant CLK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL	Binding affinity to CLK3	B	5.96	pKd	1100	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075282] [GtoPdb: 1992] [UniProtKB: O35492]
ChEMBL	Inhibition of mouse recombinant GST-tagged CLK3 using GRSRSRSRSRSR as substrate	B	5	pIC50	>10000	nM	IC50	J Med Chem (2011) 54: 4172-4186 [PMID:21615147]
ChEMBL	Inhibition of mouse recombinant GST-tagged CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	5	pIC50	>10000	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of mouse recombinant CLK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	5.52	pIC50	3000	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
GtoPdb	-	-	8.35	pIC50	4.5	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1]
ChEMBL	Binding affinity to CLK4	B	7.15	pKd	70	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 4/Dual specificity protein kinase CLK4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075283] [GtoPdb: 1993] [UniProtKB: O35493]
ChEMBL	Inhibition of mouse recombinant GST-tagged CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.19	pIC50	64	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of mouse recombinant CLK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.51	pIC50	31	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual specificity tyrosine-phosphorylation-regulated kinase 1A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5508] [GtoPdb: 2009] [UniProtKB: Q63470]
ChEMBL	Inhibition of rat recombinant GST-tagged DYRK1A using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting	B	7.4	pIC50	40	nM	IC50	J Med Chem (2011) 54: 4172-4186 [PMID:21615147]
ChEMBL	Inhibition of rat recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.4	pIC50	40	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of rat DYRK1A isolated from brain using KKISGRLSPIMTEQ as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	8	pIC50	10	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
GtoPdb	-	-	10.4	pIC50	0.04	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL	Binding affinity to DYRK1A	B	8.11	pKd	7.8	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant full length GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.22	pIC50	60	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant C-terminal truncated GST-tagged DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.26	pIC50	55	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of DYRK1A (unknown origin)	B	7.26	pIC50	55	nM	IC50	J Med Chem (2017) 60: 2052-2070 [PMID:28206758]
ChEMBL	Inhibition of human recombinant DYRK1A expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.68	pIC50	21	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
ChEMBL	Inhibition of human DYRK1A using [33P]-ATP incubated for 120 mins	B	8.12	pIC50	7.6	nM	IC50	J Med Chem (2016) 59: 10315-10321 [PMID:27766861]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4750] [GtoPdb: 2009] [UniProtKB: Q61214]
ChEMBL	Binding affinity to DYRK1A in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	7.19	pKd	65	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
dual specificity tyrosine phosphorylation regulated kinase 1A in Rat [GtoPdb: 2009] [UniProtKB: Q63470]
GtoPdb	-	-	10.4	pIC50	0.04	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
ChEMBL	Binding affinity to DYRK1B	B	6.85	pKd	140	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	7.11	pIC50	77	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
ChEMBL	Inhibition of human recombinant GST-tagged DYRK1B expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.36	pIC50	44	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human DYRK1B using [33P]-ATP incubated for 120 mins	B	7.43	pIC50	37	nM	IC50	J Med Chem (2016) 59: 10315-10321 [PMID:27766861]
dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630]
ChEMBL	Binding affinity to DYRK2	B	6.35	pKd	450	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.66	pIC50	220	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
ChEMBL	Inhibition of human recombinant GST-tagged DYRK2 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	7.14	pIC50	73	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant GST-tagged DYRK2 using KKISGRLSPIMTEQ as substrate and [gamma32]-ATP after 30 mins by scintillation counting	B	7.46	pIC50	35	nM	IC50	J Med Chem (2011) 54: 4172-4186 [PMID:21615147]
GtoPdb	-	-	9.46	pIC50	0.35	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781]
ChEMBL	Inhibition of human recombinant DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate	B	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2013) 62: 728-737 [PMID:23454515]
ChEMBL	Inhibition of human recombinant GST-tagged DYRK3 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.49	pIC50	320	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
dual specificity tyrosine phosphorylation regulated kinase 4/Dual specificity tyrosine-phosphorylation-regulated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075115] [GtoPdb: 2013] [UniProtKB: Q9NR20]
GtoPdb	-	-	6.28	pIC50	520	nM	IC50	J Med Chem (2012) 55: 9312-30 [PMID:22998443]
ChEMBL	Inhibition of human recombinant GST-tagged DYRK4 expressed in Escherichia coli using GRSRSRSRSRSR as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.28	pIC50	520	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
CDC like kinase 1/Dual specificty protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759]
ChEMBL	Binding affinity to CLK1	B	7.12	pKd	75	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of CLK1 (unknown origin)	B	7.15	pIC50	71	nM	IC50	J Med Chem (2017) 60: 2052-2070 [PMID:28206758]
CDC like kinase 1 in Mouse [GtoPdb: 1990] [UniProtKB: P22518]
GtoPdb	-	-	10.82	pIC50	0.01	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840]
ChEMBL	Binding affinity to GSK3A	B	6.26	pKd	550	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
ChEMBL	Inhibition of human recombinant GSK3alpha expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.68	pIC50	210	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176843] [GtoPdb: 2029] [UniProtKB: Q2NL51]
ChEMBL	Binding affinity to GSK3A in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	5.48	pKd	3274	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of human recombinant GSK3beta expressed in insect cells using YRRAAVPPSPSLSRHSSPHQ-phosphoS-EDEEE as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.42	pIC50	380	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02]
ChEMBL	Binding affinity to HIPK1	B	6.49	pKd	320	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
ChEMBL	Binding affinity to HIPK3	B	6.64	pKd	230	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617]
ChEMBL	Binding affinity to IRAK1	B	6.03	pKd	930	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
mitogen-activated protein kinase 1/Mitogen-activated protein kinase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5233] [GtoPdb: 1495] [UniProtKB: P63086]
ChEMBL	Inhibition of rat recombinant ERK2 using Ets1 as substrate and [gamma33P]ATP as substrate after 30 mins by scintillation counting	B	4.52	pIC50	>30000	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
Protein VAC14 homolog in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176841] [UniProtKB: Q80WQ2]
ChEMBL	Binding affinity to VAC14 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	4.82	pKd	15265	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL	Inhibition of human recombinant Pim1	B	5.39	pIC50	4100	nM	IC50	J Med Chem (2011) 54: 4172-4186 [PMID:21615147]
ChEMBL	Inhibition of human recombinant PIM1 expressed in Escherichia coli using histone H1 as substrate and [gamma33P]ATP after 30 mins by scintillation counting	B	6.06	pIC50	880	nM	IC50	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
GtoPdb	-	-	8.39	pIC50	4.1	nM	IC50	J Med Chem (2011) 54: 4172-86 [PMID:21615147]
TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3]
ChEMBL	Binding affinity to TAOK1	B	5.77	pKd	1700	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]
STE20 like kinase/STE20-like serine/threonine-protein kinase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176844] [GtoPdb: 2200] [UniProtKB: O54988]
ChEMBL	Binding affinity to SLK1 in mouse brain homogenate after 3 hrs by competition affinity chromatographic analysis	B	7.68	pKd	21	nM	Kd	J Med Chem (2012) 55: 9312-9330 [PMID:22998443]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]