ChEMBL ligand: CHEMBL154 (Aleve, Anaprox, Arthrosin 250, Arthrosin 250 ec, Arthrosin 500, Arthrosin 500 ec, Condrotec, Ec-naprosyn, Equiproxen, Feminax ultra, Grenoxal, Kenosyn, Laraflex, Napratec op, Naprelan, Naprosyn, Naprosyn 375, Naprosyn ec, Naproxen, NSC-750183, NSC-757239, Nycopren, PN400 COMPONENT NAPROXEN, Pranoxen continus, Prosaid, Rheuflex 250, Rheuflex 500, Rimoxyn, RS-3540, Stirlescent, Timpron, Timpron 250 ec, Timpron 500 ec, Valrox, Vimovo)
Aldo-keto reductase family 1 member C1 in Human [ChEMBL: CHEMBL5905] [UniProtKB: Q04828] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member C2 in Human [ChEMBL: CHEMBL5847] [UniProtKB: P52895] There should be some charts here, you may need to enable JavaScript!
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member C4 in Human [ChEMBL: CHEMBL4999] [UniProtKB: P17516] There should be some charts here, you may need to enable JavaScript!
5-LOX/Arachidonate 5-lipoxygenase in Rat [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] There should be some charts here, you may need to enable JavaScript!
COX-1 /Cyclooxygenase-1 in Human [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] Cyclooxygenase-1 in Bovine [ChEMBL: CHEMBL2860] [UniProtKB: O62664] Cyclooxygenase-1 in Sheep [ChEMBL: CHEMBL2949] [UniProtKB: P05979] There should be some charts here, you may need to enable JavaScript!
COX-2 /Cyclooxygenase-2 in Human [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] Cyclooxygenase-2 in Sheep [ChEMBL: CHEMBL4102] [UniProtKB: P79208] There should be some charts here, you may need to enable JavaScript!
lipase E, hormone sensitive type/Hormone-sensitive lipase in Rat [ChEMBL: CHEMBL5582] [GtoPdb: 2593] [UniProtKB: P15304] There should be some charts here, you may need to enable JavaScript!
L-PGDS/Prostaglandin-H2 D-isomerase in Mouse [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114] There should be some charts here, you may need to enable JavaScript!
Organic anion transporter 1/Solute carrier family 22 member 6 in Human [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8] Organic anion transporter 1/Solute carrier family 22 member 6 in Rat [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldo-keto reductase family 1 member C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5905] [UniProtKB: Q04828]
ChEMBL	Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis	B	4	pIC50	>100000	nM	IC50	J. Med. Chem. (2012) 55: 7746-7758 [PMID:22877157]
Aldo-keto reductase family 1 member C2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5847] [UniProtKB: P52895]
ChEMBL	Inhibition of human recombinant N-terminal His6-tagged AKR1C2 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis	B	4.5	pIC50	31300	nM	IC50	J. Med. Chem. (2012) 55: 7746-7758 [PMID:22877157]
ChEMBL	Inhibition of human recombinant AKR1C2 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 10 mins followed by protein addition by fluorometric assay	B	5.9	pIC50	1260	nM	IC50	J Med Chem (2016) 59: 7431-7444 [PMID:27486833]
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330]
ChEMBL	Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis	B	5.96	pIC50	1100	nM	IC50	J. Med. Chem. (2012) 55: 7746-7758 [PMID:22877157]
ChEMBL	Inhibition of recombinant human AKR1C3	B	6.32	pIC50	480	nM	IC50	Bioorg. Med. Chem. Lett. (2005) 15: 5170-5175 [PMID:16183274]
ChEMBL	Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as reduction in NADP+-dependent S-tetralol oxidation preincubated for 10 mins followed by protein addition by fluorometric assay	B	6.74	pIC50	180	nM	IC50	J Med Chem (2016) 59: 7431-7444 [PMID:27486833]
Aldo-keto reductase family 1 member C4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4999] [UniProtKB: P17516]
ChEMBL	Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis	B	4	pIC50	>100000	nM	IC50	J. Med. Chem. (2012) 55: 7746-7758 [PMID:22877157]
5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527]
ChEMBL	Inhibitory activity against 5-lipoxygenase catalysis (5-LO) in sonicated rat basophilic leukemia cell lysate	F	4.77	pIC50	17000	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 1	B	4.96	pIC50	11000	nM	IC50	J. Med. Chem. (2000) 43: 214-223 [PMID:10649977]
ChEMBL	Inhibition of COX1-catalyzed prostaglandin biosynthesis 10 mins of preincubation	B	4.96	pIC50	11000	nM	IC50	J. Nat. Prod. (1998) 61: 1212-1215 [PMID:9784154]
ChEMBL	Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandin	B	4.96	pIC50	11000	nM	IC50	J. Nat. Prod. (1999) 62: 294-296 [PMID:10075763]
GtoPdb	-	-	5.49	pIC50	3200	nM	IC50	J Med Chem (1997) 40: 819-24 [PMID:9057869]
ChEMBL	Inhibition activity against recombinant human Prostaglandin G/H synthase 1	B	5.49	pIC50	3200	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
ChEMBL	Compound was tested in vitro for inhibition of human platelet Prostaglandin G/H synthase 1 at 10 uM	B	6.46	pIC50	350	nM	IC50	Bioorg. Med. Chem. Lett. (1996) 6: 2281-2282
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid)	B	6.68	pIC50	211	nM	IC50	DrugMatrix in vitro pharmacology data
Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664]
ChEMBL	Inhibition of bovine seminal microsomal COX1 assessed as PGE2 production preincubated for 10 mins	B	4.96	pIC50	11000	nM	IC50	J. Nat. Prod. (1998) 61: 2-7 [PMID:9461646]
Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979]
ChEMBL	Inhibition of ovine COX1 using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately	B	4.28	pIC50	52200	nM	IC50	J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
ChEMBL	Inhibition of ovine COX1 assessed as inhibition of PGF2a production by enzyme immunoassay	B	4.31	pIC50	49000	nM	IC50	Bioorg. Med. Chem. (2013) 21: 532-539 [PMID:23219856]
ChEMBL	Inhibitory concentration against Prostaglandin H2 synthase 1 (PGHS-1) from ram seminal vesicle	B	4.68	pIC50	21000	nM	IC50	J. Med. Chem. (1996) 39: 3929-3937 [PMID:8831759]
ChEMBL	Inhibition of ovine COX1 assessed as PGF2alpha production by enzyme immunoassay	B	4.71	pIC50	19500	nM	IC50	Eur. J. Med. Chem. (2012) 47: 111-124 [PMID:22119153]
ChEMBL	Tested for inhibitory activity against Prostaglandin G/H synthase 1 from ovine	B	5.57	pIC50	2700	nM	IC50	J. Med. Chem. (1995) 38: 3895-3901 [PMID:7562922]
ChEMBL	Inhibition of ovine COX1	B	6.74	pIC50	180	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of ovine COX-1	B	6.74	pIC50	180	nM	IC50	J. Med. Chem. (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL	Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation preincubated for 5 mins followed by substrate/TMPD addition measured for 5 mins by colorimetric assay	B	7.21	pIC50	61	nM	IC50	J Med Chem (2016) 59: 7431-7444 [PMID:27486833]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL	Inhibition of human COX2 expressed in insect cells using arachidonic acid as substrate pretreated for 3 mins followed by substrate addition measured immediately	B	4.28	pIC50	52200	nM	IC50	J Nat Prod (2017) 80: 2472-2477 [PMID:28885836]
ChEMBL	Compound was tested in vitro for inhibition of human umbilical cord endothelial cells(ECV-304 cell line) Prostaglandin G/H synthase 2 at 10 uM	B	4.61	pIC50	24300	nM	IC50	Bioorg. Med. Chem. Lett. (1996) 6: 2281-2282
ChEMBL	Inhibitory activity against prostaglandin G/H synthase 2	B	4.72	pIC50	18900	nM	IC50	J. Med. Chem. (2000) 43: 214-223 [PMID:10649977]
ChEMBL	DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid)	B	4.77	pIC50	17001	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human recombinant COX2	B	4.91	pIC50	12400	nM	IC50	Bioorg. Med. Chem. Lett. (2013) 23: 163-168 [PMID:23200247]
ChEMBL	Inhibition of human recombinant COX-2	B	4.91	pIC50	12400	nM	IC50	J. Med. Chem. (2011) 54: 1356-1364 [PMID:21280601]
ChEMBL	Tested for inhibitory activity against Prostaglandin G/H synthase 2 from human	B	5.01	pIC50	9700	nM	IC50	J. Med. Chem. (1995) 38: 3895-3901 [PMID:7562922]
GtoPdb	-	-	5.6	pIC50	2500	nM	IC50	J Med Chem (1997) 40: 819-24 [PMID:9057869]
ChEMBL	Inhibition activity against recombinant human Prostaglandin G/H synthase 2	B	5.6	pIC50	2500	nM	IC50	J. Med. Chem. (1997) 40: 819-824 [PMID:9057869]
ChEMBL	Inhibition of COX2 (unknown origin) using arachidonic acid as substrate assessed as reduction in PGH2 conversion to PGG2 by measuring TMPD oxidation preincubated for 5 mins followed by substrate/TMPD addition measured for 5 mins by colorimetric assay	B	6.05	pIC50	900	nM	IC50	J Med Chem (2016) 59: 7431-7444 [PMID:27486833]
Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208]
ChEMBL	Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay	B	5.47	pIC50	3360	nM	IC50	Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364]
lipase E, hormone sensitive type/Hormone-sensitive lipase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5582] [GtoPdb: 2593] [UniProtKB: P15304]
ChEMBL	Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay	B	5.92	pIC50	1200	nM	IC50	J. Med. Chem. (2008) 51: 6478-6494 [PMID:18808096]
L-PGDS/Prostaglandin-H2 D-isomerase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4334] [GtoPdb: 1380] [UniProtKB: O09114]
ChEMBL	Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes	B	4.89	pIC50	13000	nM	IC50	J. Med. Chem. (1991) 34: 1099-1110 [PMID:1900533]
Organic anion transporter 1/Solute carrier family 22 member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641347] [GtoPdb: 1025] [UniProtKB: Q4U2R8]
ChEMBL	TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cells	F	5.24	pIC50	5800	nM	IC50	J. Pharmacol. Exp. Ther. (2000) 295: 10-15 [PMID:10991954]
Organic anion transporter 1/Solute carrier family 22 member 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1777665] [GtoPdb: 1025] [UniProtKB: O35956]
ChEMBL	TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes	F	5.7	pKi	2000	nM	Ki	Mol. Pharmacol. (1999) 55: 847-854 [PMID:10220563]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]