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Target id: 1025
Nomenclature: Organic anion transporter 1
Abbreviated Name: OAT1
Systematic Nomenclature: SLC22A6
Gene and Protein Information | ||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | 12 | 563 | 11q12.3 | SLC22A6 | solute carrier family 22 member 6 | |
Mouse | 12 | 545 | 19 5.44 cM | Slc22a6 | solute carrier family 22 (organic anion transporter), member 6 | |
Rat | 11 | 551 | 1q43 | Slc22a6 | solute carrier family 22 member 6 |
Database Links | |
Specialist databases | |
Bioparadigms SLC Tables | SLC22A6 (Hs) |
RESOLUTE | SLC22A6 (Hs) |
Other databases | |
Alphafold | Q4U2R8 (Hs), Q8VC69 (Mm), O35956 (Rn) |
ChEMBL Target | CHEMBL1641347 (Hs), CHEMBL5653 (Mm), CHEMBL1777665 (Rn) |
DrugBank Target | Q4U2R8 (Hs) |
Ensembl Gene | ENSG00000197901 (Hs), ENSMUSG00000024650 (Mm), ENSRNOG00000018215 (Rn) |
Entrez Gene | 9356 (Hs), 18399 (Mm), 29509 (Rn) |
Human Protein Atlas | ENSG00000197901 (Hs) |
KEGG Gene | hsa:9356 (Hs), mmu:18399 (Mm), rno:29509 (Rn) |
OMIM | 607582 (Hs) |
Pharos | Q4U2R8 (Hs) |
UniProtKB | Q4U2R8 (Hs), Q8VC69 (Mm), O35956 (Rn) |
Wikipedia | SLC22A6 (Hs) |
Substrates and Reaction Kinetics | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Stoichiometry | |
Unknown |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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1. Fernandez-Fernandez B, Montoya-Ferrer A, Sanz AB, Sanchez-Niño MD, Izquierdo MC, Poveda J, Sainz-Prestel V, Ortiz-Martin N, Parra-Rodriguez A, Selgas R et al.. (2011) Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat, 2011: 354908. [PMID:21716719]
2. Ichida K, Hosoyamada M, Kimura H, Takeda M, Utsunomiya Y, Hosoya T, Endou H. (2003) Urate transport via human PAH transporter hOAT1 and its gene structure. Kidney Int, 63 (1): 143-55. [PMID:12472777]
3. Nigam SK, Bhatnagar V. (2018) The systems biology of uric acid transporters: the role of remote sensing and signaling. Curr Opin Nephrol Hypertens, 27 (4): 305-313. [PMID:29847376]