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ChEMBL ligand: CHEMBL279786 (Batimastat, BB-94) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
ChEMBL | Inhibition of Tumor necrosis factor alpha converting enzyme (TACE) | B | 7.83 | pIC50 | 14.9 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
ChEMBL | Inhibition of TACE (unknown origin) using fluorogenic LAQAVRSSSR peptide as a substrate by fluorometric assay | B | 9.4 | pIC50 | 0.4 | nM | IC50 | Med Chem Res (2011) 20: 760-768 |
Fc fragment of IgE receptor II/Immunoglobulin epsilon Fc receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2940] [GtoPdb: 2935] [UniProtKB: P06734] | ||||||||
ChEMBL | Tested for inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells ( a human B-cell line) | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 23-28 [PMID:9871622] |
ChEMBL | Inhibition against CD23 (IgE receptor) proteolysis in membranes derived from RPM18866 cells | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 29-34 [PMID:9871623] |
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
GtoPdb | - | - | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 1415-1420 |
ChEMBL | Inhibition of human fibroblast collagenase, matrix metalloprotease-1 | B | 9.3 | pKi | 0.5 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 1415-1420 |
ChEMBL | Inhibition of human MMP-1 | B | 5.66 | pIC50 | 2200 | nM | IC50 | RSC Med Chem (2021) 12: 1698-1708 [PMID:34778771] |
ChEMBL | Inhibitory activity towards human recombinant fibroblast collagenase | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 23-28 [PMID:9871622] |
ChEMBL | 50% inhibition of human recombinant fibroblast collagenase (MMP-1, HFC) | B | 8.3 | pIC50 | 5 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 193-198 |
ChEMBL | Inhibitory activity towards human recombinant fibroblast collagenase | B | 8.59 | pIC50 | 2.6 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 29-34 [PMID:9871623] |
ChEMBL | In vitro inhibitory activity against matrix metalloprotease 1 isolated from the culture medium of human skin fibroblasts induced with PMA | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 3251-3256 [PMID:9873712] |
GtoPdb | - | - | 9 | pIC50 | 0.99 | nM | IC50 | J Med Chem (2003) 46: 3514-25 [PMID:12877590] |
ChEMBL | Inhibition of human Matrix metalloprotease-1 (MMP-1) | B | 9 | pIC50 | 0.99 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
ChEMBL | Inhibition of Matrix metalloprotease-1 | B | 9.12 | pIC50 | 0.75 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 567-570 [PMID:11229773] |
ChEMBL | Inhibition of MMP-1 (unknown origin) | B | 9.12 | pIC50 | 0.75 | nM | IC50 | Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437] |
ChEMBL | Activity against Matrix metalloprotease-1 (MMP-1). | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (1998) 41: 1209-1217 [PMID:9548812] |
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2003) 46: 3514-25 [PMID:12877590] |
ChEMBL | Inhibition of Matrix metalloprotease-13 | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
ChEMBL | Inhibition of human MMP-14 | B | 5.55 | pIC50 | 2800 | nM | IC50 | RSC Med Chem (2021) 12: 1698-1708 [PMID:34778771] |
ChEMBL | Inhibition of human matrix metalloprotease-14 expressed in Escherichia coli | B | 7.33 | pIC50 | 47 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 181-183 [PMID:15582436] |
ChEMBL | Inhibition of Matrix metalloprotease-14 | B | 8.34 | pIC50 | 4.6 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
ChEMBL | Activity against deletion mutant of MT1-MMP lacking the transmembrane domain (deltaMT1) | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1998) 41: 1209-1217 [PMID:9548812] |
ChEMBL | Inhibition of Matrix metalloprotease-14 | B | 8.54 | pIC50 | 2.9 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 567-570 [PMID:11229773] |
ChEMBL | Inhibition of MMP-14 (unknown origin) | B | 8.54 | pIC50 | 2.9 | nM | IC50 | Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437] |
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
ChEMBL | Inhibition of human MMP-2 | B | 5.74 | pIC50 | 1800 | nM | IC50 | RSC Med Chem (2021) 12: 1698-1708 [PMID:34778771] |
ChEMBL | Inhibition of human matrix metalloprotease-2 expressed in Sf9 insect cells | B | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 181-183 [PMID:15582436] |
ChEMBL | Compound concentration for 50% inhibition of human recombinant gelatinase A (MMP-2). | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 193-198 |
ChEMBL | Inhibition of MMP-2 (unknown origin) | B | 8.4 | pIC50 | 4 | nM | IC50 | Eur J Med Chem (2020) 194: 112260-112260 [PMID:32224379] |
ChEMBL | In vitro inhibitory activity against matrix metalloprotease 2 isolated from human HT1080 fibrosarcoma cells induced with TNF | B | 8.68 | pIC50 | 2.1 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 3251-3256 [PMID:9873712] |
ChEMBL | Activity against Matrix metalloprotease-2 (MMP-2). | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (1998) 41: 1209-1217 [PMID:9548812] |
ChEMBL | Inhibition of human matrix metalloprotease-2 (MMP-2) | B | 9.14 | pIC50 | 0.73 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
ChEMBL | Ability to inhibit the matrix metalloprotease-2 by method of Knight et al using the fluorogenic peptide substrate. | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 567-570 [PMID:11229773] |
ChEMBL | Inhibition of MMP-2 (unknown origin) | B | 9.3 | pIC50 | 0.5 | nM | IC50 | Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437] |
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
ChEMBL | Inhibition of human MMP-3 | B | 5.25 | pIC50 | 5600 | nM | IC50 | RSC Med Chem (2021) 12: 1698-1708 [PMID:34778771] |
ChEMBL | 50% inhibition of human recombinant stromelysin (MMP-3, HFS) | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 193-198 |
ChEMBL | In vitro inhibitory activity against human recombinant matrix metalloprotease 3 | B | 9.12 | pIC50 | 0.75 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 3251-3256 [PMID:9873712] |
ChEMBL | Ability to inhibit the matrix metalloprotease-3 by method of Knight et al using the fluorogenic peptide substrate. | B | 9.14 | pIC50 | 0.73 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 567-570 [PMID:11229773] |
ChEMBL | Inhibition of MMP-3 (unknown origin) | B | 9.14 | pIC50 | 0.73 | nM | IC50 | Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437] |
ChEMBL | Activity against Matrix metalloprotease-3 (MMP-3). | B | 9.19 | pIC50 | 0.65 | nM | IC50 | J Med Chem (1998) 41: 1209-1217 [PMID:9548812] |
GtoPdb | - | - | 9.19 | pIC50 | 0.65 | nM | IC50 | J Med Chem (1998) 41: 1209-17 [PMID:9548812] |
ChEMBL | Inhibition of human matrix metalloprotease-3 (MMP-3) | B | 9.25 | pIC50 | 0.56 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
ChEMBL | Inhibition of human MMP-7 | B | 5.15 | pIC50 | 7000 | nM | IC50 | RSC Med Chem (2021) 12: 1698-1708 [PMID:34778771] |
ChEMBL | 50% inhibition of human recombinant Matrilysin | B | 8.22 | pIC50 | 6 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 193-198 |
ChEMBL | In vitro inhibitory activity against human recombinant matrix metalloprotease 7 | B | 8.62 | pIC50 | 2.4 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 3251-3256 [PMID:9873712] |
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
ChEMBL | Inhibition of human MMP-8 | B | 6.15 | pIC50 | 700 | nM | IC50 | RSC Med Chem (2021) 12: 1698-1708 [PMID:34778771] |
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
ChEMBL | Inhibition of human matrix metalloprotease-9 expressed in Sf9 insect cells | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 181-183 [PMID:15582436] |
ChEMBL | Inhibition of MMP-9 (unknown origin) | B | 9 | pIC50 | 1 | nM | IC50 | Eur J Med Chem (2020) 194: 112260-112260 [PMID:32224379] |
ChEMBL | Inhibition of Matrix metalloprotease-9 | B | 9.17 | pIC50 | 0.67 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 567-570 [PMID:11229773] |
ChEMBL | Inhibition of MMP-9 (unknown origin) | B | 9.17 | pIC50 | 0.67 | nM | IC50 | Eur J Med Chem (2021) 223: 113623-113623 [PMID:34157437] |
ChEMBL | Inhibition of human matrix metalloprotease-9 (MMP-9) | B | 9.22 | pIC50 | 0.6 | nM | IC50 | J Med Chem (2003) 46: 3514-3525 [PMID:12877590] |
ChEMBL | Activity against Matrix metalloprotease-9 (MMP-9). | B | 9.7 | pIC50 | 0.2 | nM | IC50 | J Med Chem (1998) 41: 1209-1217 [PMID:9548812] |
Snake venom metalloproteinase Bap1 in Bothrops asper (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079851] [UniProtKB: P83512] | ||||||||
ChEMBL | Inhibition of snake venom BaP1 using Abz-Ala-Gly-Leu-Ala-Nba as substrate incubated for 30 mins prior to substrate addition by fluorescence spectrophotometry | B | 5.92 | pIC50 | 1200 | nM | IC50 | ACS Med Chem Lett (2012) 3: 540-543 [PMID:24900507] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]