WB 4101 [Ligand Id: 499] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL25554 (WB-4101)
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
  • Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
  • α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
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  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
  • α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
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  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
  • α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
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  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
  • α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909]
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  • α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
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  • α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
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  • D2 receptor/Dopamine D2 receptor in Rat [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
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  • D3 receptor/Dopamine D3 receptor in Rat [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
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  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
  • 5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
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  • 5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1A adrenergic receptor B 9.37 pKi 0.43 nM Ki J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Displacement of [3H]prazosin from human cloned alpha1A adrenoceptor expressed in CHO cells B 9.37 pKi 0.43 nM Ki J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]prazosin from human adrenergic alpha1A expressed in CHO cells B 9.37 pKi 0.43 nM Ki Bioorg Med Chem (2010) 18: 7065-7077 [PMID:20801662]
ChEMBL Binding affinity to adrenergic alpha1A receptor (unknown origin) B 9.37 pKi 0.43 nM Ki Med Chem Res (2011) 20: 1455-1464
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1A adrenergic receptor expressed in CHO cell membranes after 30 mins B 9.37 pKi 0.43 nM Ki J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL Affinity constant towards human recombinant Alpha-1A adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay B 9.37 pKi 0.43 nM Ki J Med Chem (2003) 46: 1504-1511 [PMID:12672251]
ChEMBL Antagonistic affinity tested against isolated Human recombinant Thoracic Aorta Alpha-1A adrenergic receptor F 9.37 pKi 0.43 nM Ki J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Binding affinity measured in CHO cells expressing human cloned Alpha-1A adrenergic receptor expressed as pKi B 9.37 pKi 0.43 nM Ki J Med Chem (2003) 46: 4895-4903 [PMID:14584940]
ChEMBL The binding affinity was evaluated on cloned human alpha-1A adrenergic receptor expressed in chinese hamster ovary(CHO) cells by using [3H]prazosin as radioligand. B 9.37 pKi 9.37 nM Log Ki J Med Chem (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Binding affinity to adrenergic alpha1A receptor (unknown origin) B 9.37 pKi 0.43 nM Ki Med Chem Res (2011) 20: 1455-1464
ChEMBL Binding affinity against Alpha-1A adrenergic receptor from human clone B 9.43 pKi 0.37 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL Displacement of [3H]prazosin from human recombinant adrenergic alpha-1A receptor expressed in CHO cell membranes incubated for 60 mins B 9.8 pKi 0.16 nM Ki J Med Chem (2020) 63: 433-439 [PMID:31834797]
ChEMBL Binding affinity was tested on human Alpha-1A adrenergic receptor B 9.8 pKi 0.16 nM Ki J Med Chem (1997) 40: 1293-1315 [PMID:9135028]
GtoPdb - - 9.8 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
FEBS Lett (1998) 422: 279-83 [PMID:9490024];
Eur J Pharmacol (1999) 370: 337-43 [PMID:10334511];
Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
ChEMBL Antagonist activity at human recombinant alpha1A adrenoceptor assessed as inhibition of epinephrine-induced intracellular Ca2+ release F 9 pIC50 1 nM IC50 J Med Chem (2014) 57: 4543-4557 [PMID:24805037]
ChEMBL Antagonist activity against human recombinant alpha1 receptor expressed in CHOK1 cells assessed as reduction in epinephrine-induced increase in intracellular Ca2+ levels F 9 pIC50 1 nM IC50 Eur J Med Chem (2015) 92: 221-235 [PMID:25557493]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL Binding affinity towards Alpha-1A adrenergic receptor in bovine brain using [3H]prazosin as radioligand B 9.21 pKi 0.62 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
ChEMBL Binding affinity of compound towards Alpha-1 adrenergic receptor using [3H]prazosin 0.5 nM ligand in frontal cortex calf was determined B 9.22 pKi 0.6 nM Ki J Med Chem (1997) 40: 952-960 [PMID:9083484]
ChEMBL Binding affinity against Alpha-1A adrenergic receptor from bovine clone B 9.46 pKi 0.35 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL Activity at adrenergic alpha 1A receptor assessed as antagonsim of noradrenaline-induced contraction of Sprague-Dawley rat prostate F 9.18 pKd 0.66 nM Kd J Med Chem (2006) 49: 7140-7149 [PMID:17125266]
ChEMBL Antagonistic affinity tested against isolated Rat Prostate Alpha-1A adrenergic receptor F 9.27 pKd 0.54 nM Kd J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Antagonistic activity against (-)-noradrenaline-induced contraction of rat prostatic vas deferens (Alpha-1A adrenergic receptor ) F 9.36 pKd 0.44 nM Kd J Med Chem (2003) 46: 1504-1511 [PMID:12672251]
ChEMBL Activity at adrenergic alpha 1A receptor assessed as antagonism of noradrenaline-induced contraction of Sprague-Dawley rat vas deferens F 9.36 pKd 0.44 nM Kd J Med Chem (2006) 49: 7140-7149 [PMID:17125266]
ChEMBL Antagonistic affinity tested against isolated Rat Prostatic Vas Deferens Alpha-1A adrenergic receptor F 9.51 pKd 0.31 nM Kd J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Antagonistic activity at ADRA1A in isolated rat prostatic vas deferens F 9.51 pKd 0.31 nM Kd Bioorg Med Chem Lett (2006) 16: 150-153 [PMID:16216506]
ChEMBL Binding affinity towards Alpha-1A adrenergic receptor in rat hippocampal membranes using [3H]prazosin as radioligand B 8.89 pKi 1.29 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
ChEMBL Overall binding displacement in tissues containing only the Alpha-1A adrenergic receptor from rat submaxillary gland B 10.1 pKi 0.08 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
GtoPdb - - 10.2 pKi - - - J Biol Chem (2001) 276: 25366-71 [PMID:11331292];
Br J Pharmacol (1997) 122: 849-58 [PMID:9384500]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL Binding affinity towards Alpha-1B adrenergic receptor cloned receptor hamster smooth muscle using [3H]prazosin as radioligand B 7.24 pKi 57.34 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
ChEMBL Binding affinity against Alpha-1B adrenergic receptor from hamster clones. B 7.43 pKi 37 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL The binding affinity was evaluated on cloned human alpha-1B adrenergic receptor expressed in chinese hamster ovary(CHO) cells by using [3H]prazosin as radioligand. B 8 pKi 8 nM Log Ki J Med Chem (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1B adrenergic receptor B 8 pKi 10 nM Ki J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1B adrenoceptor expressed in CHO cells B 8 pKi 10 nM Ki J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]prazosin from human adrenergic Alpha-1B expressed in CHO cells B 8 pKi 10 nM Ki Bioorg Med Chem (2010) 18: 7065-7077 [PMID:20801662]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1B adrenergic receptor expressed in CHO cell membranes after 30 mins B 8 pKi 10 nM Ki J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL Affinity constant towards human recombinant Alpha-1B adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay B 8 pKi 10 nM Ki J Med Chem (2003) 46: 1504-1511 [PMID:12672251]
ChEMBL Affinity constant on CHO cells expressing Human recombinant Alpha-1B adrenergic receptor B 8 pKi 10 nM Ki J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Binding affinity measured in CHO cells expressing human cloned Alpha-1B adrenergic receptor expressed as pKi B 8 pKi 10 nM Ki J Med Chem (2003) 46: 4895-4903 [PMID:14584940]
ChEMBL Binding affinity against Alpha-1B adrenergic receptor from human clone B 8 pKi 9.9 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL Binding affinity was tested on human Alpha-1B adrenergic receptor B 8.6 pKi 2.51 nM Ki J Med Chem (1997) 40: 1293-1315 [PMID:9135028]
GtoPdb - - 9 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
ChEMBL Displacement of [3H]prazosin from human recombinant adrenergic alpha-1B receptor expressed in CHO cell membranes incubated for 60 mins B 10.42 pKi 0.04 nM Ki J Med Chem (2020) 63: 433-439 [PMID:31834797]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptor F 8.16 pKd 6.92 nM Kd J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Antagonistic activity at ADRA1B in rat spleen F 8.2 pKd 6.31 nM Kd Bioorg Med Chem Lett (2006) 16: 150-153 [PMID:16216506]
ChEMBL Antagonistic activity against (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) F 8.21 pKd 6.17 nM Kd J Med Chem (2003) 46: 1504-1511 [PMID:12672251]
ChEMBL Activity at adrenergic alpha 1B receptor assessed as antagonsim of phenylephrine-induced contraction of Sprague-Dawley rat spleen F 8.21 pKd 6.17 nM Kd J Med Chem (2006) 49: 7140-7149 [PMID:17125266]
ChEMBL Binding affinity towards Alpha-1B adrenergic receptor native receptor in rat liver using [3H]prazosin as radioligand B 7.59 pKi 25.64 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
ChEMBL Overall binding displacement in tissues containing only the Alpha-1B adrenergic receptor (rat spleen, rat liver) B 8.1 pKi 8 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
ChEMBL Binding affinity against Alpha-1D adrenergic receptor, from human clones. B 9.1 pKi 0.8 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL Displacement of [3H]prazosin from human recombinant alpha1D adrenergic receptor expressed in CHO cell membranes after 30 mins B 9.29 pKi 0.51 nM Ki J Med Chem (2013) 56: 584-588 [PMID:23252794]
ChEMBL Displacement of [3H]prazosin from human cloned Alpha-1D adrenergic receptor B 9.29 pKi 0.51 nM Ki J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Affinity constant towards human recombinant Alpha-1D adrenergic receptor using [3H]prazosin (from CHO cells) as radioligand by radioligand binding assay B 9.29 pKi 0.51 nM Ki J Med Chem (2003) 46: 1504-1511 [PMID:12672251]
ChEMBL Affinity constant on CHO cells expressing Human recombinant Alpha-1D adrenergic receptor B 9.29 pKi 0.51 nM Ki J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Binding affinity measured in CHO cells expressing human cloned Alpha-1D adrenergic receptor expressed as pKi B 9.29 pKi 0.51 nM Ki J Med Chem (2003) 46: 4895-4903 [PMID:14584940]
ChEMBL Displacement of [3H]prazosin from human cloned alpha1D adrenoceptor expressed in CHO cells B 9.29 pKi 0.51 nM Ki J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]prazosin from human adrenergic Alpha-1D expressed in CHO cells B 9.29 pKi 0.51 nM Ki Bioorg Med Chem (2010) 18: 7065-7077 [PMID:20801662]
ChEMBL The binding affinity was evaluated on cloned human alpha-1D adrenergic receptor expressed in chinese hamster ovary(CHO) cells by using [3H]prazosin as radioligand. B 9.29 pKi 9.29 nM Log Ki J Med Chem (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Binding affinity was tested on human Alpha-1D adrenergic receptor B 9.6 pKi 0.25 nM Ki J Med Chem (1997) 40: 1293-1315 [PMID:9135028]
GtoPdb - - 9.6 pKi - - - Br J Pharmacol (1997) 121: 1127-35 [PMID:9249248];
Mol Pharmacol (1995) 48: 250-8 [PMID:7651358];
Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) F 8.6 pKd 2.51 nM Kd J Med Chem (2003) 46: 1504-1511 [PMID:12672251]
ChEMBL Activity at adrenergic alpha 1D receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat thoracic aorta F 8.6 pKd 2.51 nM Kd J Med Chem (2006) 49: 7140-7149 [PMID:17125266]
ChEMBL Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptor F 8.8 pKd 1.58 nM Kd J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Antagonistic activity at ADRA1D in rat thoracic aorta F 8.8 pKd 1.58 nM Kd Bioorg Med Chem Lett (2006) 16: 150-153 [PMID:16216506]
ChEMBL Binding affinity towards Alpha-1D adrenergic receptor in rat brain using [3H]prazosin as radioligand B 8.2 pKi 6.26 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
ChEMBL Binding affinity against Alpha-1D adrenergic receptor, from rat clones. B 8.92 pKi 1.2 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913]
ChEMBL Binding affinity against Alpha-2A adrenergic receptor, from human clones. B 8.46 pKi 3.5 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
GtoPdb - - 8.9 pKi - - - Mol Pharmacol (1992) 42: 1-5 [PMID:1353247];
Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642];
Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877]
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL327] [GtoPdb: 25] [UniProtKB: P22909]
ChEMBL Activity at adrenergic alpha 2A receptor assessed as antagonism on noradrenaline-induced contraction of Sprague-Dawley rat vas deferens F 6.59 pKd 257.04 nM Kd J Med Chem (2006) 49: 7140-7149 [PMID:17125266]
ChEMBL The compound was tested for binding affinity against alpha-2d-adrenoceptor, from rat clones. B 7.34 pKi 46 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089]
ChEMBL Binding affinity against Alpha-2B adrenergic receptor from human clones. B 7.55 pKi 28 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
GtoPdb - - 8.4 pKi - - - J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470];
Mol Pharmacol (1992) 42: 1-5 [PMID:1353247];
Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642];
Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877]
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825]
ChEMBL Binding affinity against Alpha-2C adrenergic receptor from human clones. B 9.1 pKi 0.8 nM Ki J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
GtoPdb - - 9.4 pKi - - - J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470];
Mol Pharmacol (1992) 42: 1-5 [PMID:1353247];
Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642];
Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human recombinant CA1 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay B 5 pKi >10000 nM Ki J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human recombinant CA2 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay B 5 pKi >10000 nM Ki J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human recombinant CA4 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay B 5 pKi >10000 nM Ki J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human recombinant CA9 assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay B 5 pKi >10000 nM Ki J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL Inhibition of human recombinant CA5A assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay B 5 pKi >10000 nM Ki J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL Inhibition of human recombinant CA5B assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay B 5 pKi >10000 nM Ki J Med Chem (2022) 65: 13946-13966 [PMID:36201615]
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169]
ChEMBL Displacement of [3H]spiperone from rat brain Dopamine receptor D2 B 6.91 pKi 123.03 nM Ki J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL The binding affinity was evaluated on Dopamine receptor D2 expressed in rat striatum by using [3H]spiperone as radioligand B 6.91 pKi 6.91 nM Log Ki J Med Chem (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Binding affinity towards Dopamine receptor D2 in rat striatum using [3H]spiperone as radioligand B 6.91 pKi 122.8 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020]
ChEMBL Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. B 6.97 pKi 107 nM Ki J Med Chem (1993) 36: 1499-1500 [PMID:8098771]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908]
ChEMBL The binding affinity was evaluated on cloned human 5-hydroxytryptamine 1A receptor expressed in HeLa cells by using DPAT as radioligand. B 8.68 pKi 8.68 nM Log Ki J Med Chem (1999) 42: 2961-2968 [PMID:10425105]
ChEMBL Displacement of [3H]8-hydroxy-2-(di-n-propylamino)tetralin from human 5-hydroxytryptamine 1A receptor B 8.68 pKi 2.09 nM Ki J Med Chem (1999) 42: 4214-4224 [PMID:10514291]
ChEMBL Affinity constant on CHO cells expressing Human recombinant 5-hydroxytryptamine receptor 1A B 8.68 pKi 2.09 nM Ki J Med Chem (2002) 45: 1633-1643 [PMID:11931617]
ChEMBL Displacement of [3H]8-OH-DPAT from human cloned 5HT1A receptor expressed in human HeLa cells B 8.68 pKi 2.09 nM Ki J Med Chem (2008) 51: 6359-6370 [PMID:18817363]
ChEMBL Displacement of [3H]8-OH-DPAT from human adrenergic 5HT1A expressed in human HeLa cells cells B 8.68 pKi 2.09 nM Ki Bioorg Med Chem (2010) 18: 7065-7077 [PMID:20801662]
ChEMBL Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in HeLa cell membranes after 30 mins B 8.68 pKi 2.09 nM Ki J Med Chem (2013) 56: 584-588 [PMID:23252794]
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor in rat hypocampus membrane using [3H]8-OH-DPAT as radioligand B 8.14 pKi 7.26 nM Ki J Med Chem (1996) 39: 2253-2258 [PMID:8667368]
ChEMBL Binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [125I]trans-8-OH-PIPAT in membrane homogenates of hippocampal tissue of rat brain B 8.57 pKi 2.68 nM Ki J Med Chem (1993) 36: 3161-3165 [PMID:8230102]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842]
ChEMBL The binding affinity was evaluated on 5-hydroxytryptamine 2A receptor expressed in rat cortex by using [3H]ketanserin as radioligand. B 6 pKi 6 nM Log Ki J Med Chem (1999) 42: 2961-2968 [PMID:10425105]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]