ChEMBL ligand: CHEMBL9324 (NSC-102778, NSC-156315, Tetraethylammonium cation, Tetraethylammonium ion, Tetramon)
Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966] Organic cation transporter 1/Solute carrier family 22 member 1 in Rat [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577] Organic cation transporter 2/Solute carrier family 22 member 2 in Rat [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2] There should be some charts here, you may need to enable JavaScript!
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388] There should be some charts here, you may need to enable JavaScript!
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952] There should be some charts here, you may need to enable JavaScript!
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1] There should be some charts here, you may need to enable JavaScript!
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6] There should be some charts here, you may need to enable JavaScript!
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258] There should be some charts here, you may need to enable JavaScript!
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050] There should be some charts here, you may need to enable JavaScript!
Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390] There should be some charts here, you may need to enable JavaScript!
Kv1.6 in Human [GtoPdb: 543] [UniProtKB: P17658] There should be some charts here, you may need to enable JavaScript!
Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8] Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] There should be some charts here, you may need to enable JavaScript!
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322] There should be some charts here, you may need to enable JavaScript!
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387] There should be some charts here, you may need to enable JavaScript!
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953] There should be some charts here, you may need to enable JavaScript!
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] There should be some charts here, you may need to enable JavaScript!
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462] There should be some charts here, you may need to enable JavaScript!
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956] There should be some charts here, you may need to enable JavaScript!
Kv3.4 in Rat [GtoPdb: 551] [UniProtKB: Q63734] There should be some charts here, you may need to enable JavaScript!
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2] There should be some charts here, you may need to enable JavaScript!
Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526] There should be some charts here, you may need to enable JavaScript!
Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525] There should be some charts here, you may need to enable JavaScript!
Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696] There should be some charts here, you may need to enable JavaScript!
Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Organic cation transporter 1/Solute carrier family 22 member 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073664] [GtoPdb: 1019] [UniProtKB: O08966]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	F	6.27	pIC50	540	nM	IC50	Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 1/Solute carrier family 22 member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073670] [GtoPdb: 1019] [UniProtKB: Q63089]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake in Xenopus laevis oocytes	F	4	pKi	100000	nM	Ki	J Pharmacol Exp Ther (2000) 292: 1146-1152 [PMID:10688634]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells	F	4.33	pKi	46600	nM	Ki	J Pharmacol Exp Ther (1998) 287: 800-805 [PMID:9808712]
Organic cation transporter 2/Solute carrier family 22 member 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073662] [GtoPdb: 1020] [UniProtKB: O70577]
ChEMBL	TP_TRANSPORTER: inhibition of MPP+ uptake (MPP+: 1 uM) in Xenopus laevis oocytes	F	5.46	pIC50	3500	nM	IC50	Biochem Biophys Res Commun (2002) 296: 644-650 [PMID:12176030]
Organic cation transporter 2/Solute carrier family 22 member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770032] [GtoPdb: 1020] [UniProtKB: Q9R0W2]
ChEMBL	TP_TRANSPORTER: inhibition of TEA uptake (apical to cell) in OCT2-expressing MDCK cells	F	4.28	pKi	52200	nM	Ki	J Pharmacol Exp Ther (1998) 287: 800-805 [PMID:9808712]
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470]
ChEMBL	Inhibition of Kv1.1 (unknown origin)	B	4.52	pIC50	30000	nM	IC50	J Med Chem (2017) 60: 2245-2256 [PMID:28225274]
Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388]
GtoPdb	-	-	3.5	pKd	300000	nM	Kd	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
KCa2.1 in Human [GtoPdb: 381] [UniProtKB: Q92952]
GtoPdb	-	-	2.7	pIC50	-	-	-	Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.2 in Human [GtoPdb: 382] [UniProtKB: Q9H2S1]
GtoPdb	-	-	2.7	pIC50	-	-	-	Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KCa2.3 in Human [GtoPdb: 383] [UniProtKB: Q9UGI6]
GtoPdb	-	-	2.7	pIC50	-	-	-	Prog Neurobiol (2010) 91: 242-55 [PMID:20359520]
KNa1.1 in Rat [GtoPdb: 385] [UniProtKB: Q9Z258]
GtoPdb	-	-	2	pIC50	-	-	-	Trends Neurosci (2005) 28: 422-8 [PMID:15979166]
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
GtoPdb	-	-	4.21	pKi	-	-	-	J Biol Chem (1994) 269: 20468-74 [PMID:8051145]
Kv1.3 in Mouse [GtoPdb: 540] [UniProtKB: P16390]
GtoPdb	-	-	2	pKd	10000000	nM	Kd	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv1.6 in Human [GtoPdb: 543] [UniProtKB: P17658]
GtoPdb	-	-	2.2	pIC50	7000000	nM	IC50	EMBO J (1990) 9: 1749-56 [PMID:2347305]
Kv1.7 in Human [GtoPdb: 544] [UniProtKB: Q96RP8]
GtoPdb	-	-	4.1	pKd	-	-	-	Eur J Hum Genet (2002) 10: 36-43 [PMID:11896454]
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2]
GtoPdb	-	-	1.1	pIC50	-	-	-	J Biol Chem (1998) 273: 5851-7 [PMID:9488722]
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322]
GtoPdb	-	-	1.3	pIC50	-	-	-	Am J Physiol Renal Physiol (2000) 278: F1013-21 [PMID:10836990]
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387]
GtoPdb	-	-	2	pIC50	10000000	nM	IC50	Biochem J (2006) 396: 363-9 [PMID:16478442]
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
GtoPdb	-	-	2.6	pIC50	2600000	nM	IC50	Am J Physiol (1998) 274: G901-11 [PMID:9612272]
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388]
GtoPdb	-	-	3.7	pIC50	200000	nM	IC50	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462]
GtoPdb	-	-	4.2	pIC50	63000	nM	IC50	J Physiol (Lond.) (2002) 538: 405-19 [PMID:11790809]
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956]
GtoPdb	-	-	3.9	pIC50	140000	nM	IC50	Proc Biol Sci (1992) 248: 9-18 [PMID:1381835]
Kv3.4 in Rat [GtoPdb: 551] [UniProtKB: Q63734]
GtoPdb	-	-	3.5	pIC50	300000	nM	IC50	FEBS Lett (1991) 278: 211-6 [PMID:1840526]; EMBO J (1992) 11: 2473-86 [PMID:1378392]
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2]
GtoPdb	-	-	2	pIC50	-	-	-	Mol Cell Biochem (2002) 238: 69-79 [PMID:12349911]
Kv7.2 in Human [GtoPdb: 561] [UniProtKB: O43526]
GtoPdb	-	-	3.9	pIC50	130000	nM	IC50	Br J Pharmacol (2000) 129: 413-5 [PMID:10711337]; Mol Pharmacol (2000) 58: 591-600 [PMID:10953053]
Kv7.3 in Human [GtoPdb: 562] [UniProtKB: O43525]
GtoPdb	-	-	1.5	pIC50	-	-	-	Br J Pharmacol (2000) 129: 413-5 [PMID:10711337]
Kv7.4 in Human [GtoPdb: 563] [UniProtKB: P56696]
GtoPdb	-	-	1.3	pIC50	52000000	nM	IC50	J Biol Chem (2008) 283: 30668-76 [PMID:18786918]
Kv7.5 in Human [GtoPdb: 564] [UniProtKB: Q9NR82]
GtoPdb	-	-	1.5	pIC50	-	-	-	J Biol Chem (2000) 275: 22395-400 [PMID:10787416]; J Biol Chem (2000) 275: 24089-95 [PMID:10816588]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]