Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	12	555	6q25.3	SLC22A2	solute carrier family 22 member 2
Mouse	12	553	17 8.61 cM	Slc22a2	solute carrier family 22 (organic cation transporter), member 2
Rat	12	555	1q11	Slc22a2	solute carrier family 22 member 2

Previous and Unofficial Names

OCT2r | organic cation transporter 2 | solute carrier family 22 (organic cation transporter), member 2 | Orct2 | solute carrier family 22 (organic cation transporter)

Database Links
Specialist databases
Bioparadigms SLC Tables	SLC22A2 (Hs)
RESOLUTE	SLC22A2 (Hs)
Other databases
Alphafold	O15244 (Hs), O70577 (Mm), Q9R0W2 (Rn)
ChEMBL Target	CHEMBL1743122 (Hs), CHEMBL2073662 (Mm), CHEMBL1770032 (Rn)
Ensembl Gene	ENSG00000112499 (Hs), ENSMUSG00000040966 (Mm), ENSRNOG00000016625 (Rn)
Entrez Gene	6582 (Hs), 20518 (Mm), 29503 (Rn)
Human Protein Atlas	ENSG00000112499 (Hs)
KEGG Gene	hsa:6582 (Hs), mmu:20518 (Mm), rno:29503 (Rn)
OMIM	602608 (Hs)
Pharos	O15244 (Hs)
UniProtKB	O15244 (Hs), O70577 (Mm), Q9R0W2 (Rn)
Wikipedia	SLC22A2 (Hs)

Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference metformin Hs - - 2 cisplatin Hs - - 2

Stoichiometry
Unknown

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference decynium 22 Hs Inhibition 7.0 pKi 1 ⤷ pKi 7.0 (Ki 1x10-7 M) [1] Description: Measuring inhibition of tetraethylammonium (TEA) uptake via OCT2 expressed in Xenopus oocytes.