honokiol [Ligand Id: 11610] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL16901 (Honokiol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3736] [GtoPdb: 1614] [UniProtKB: Q9BYF1] | ||||||||
| ChEMBL | Binding affinity to human ACE2 assessed as equilibrium dissociation constant by biolayer interferometry assay | B | 4.77 | pKd | 16980 | nM | Kd | Bioorg Med Chem (2022) 67: 116838-116838 [PMID:35617790] |
| 5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
| ChEMBL | Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes | B | 5.38 | pIC50 | 4200 | nM | IC50 | Bioorg Med Chem (2009) 17: 4459-4465 [PMID:19481465] |
| GtoPdb | Inhibition of 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes. | - | 5.38 | pIC50 | 4200 | nM | IC50 | Bioorg Med Chem (2009) 17: 4459-65 [PMID:19481465] |
| CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]CP55,940 from recombinant human CB1 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | B | 5.19 | pKi | 6460 | nM | Ki | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| ChEMBL | Displacement of [3H]CP55940 from human CB1 receptor expressed in CHO cell membranes after 2 hrs | B | 8.19 | pKi | 6.46 | nM | Ki | Eur J Med Chem (2016) 116: 252-266 [PMID:27078864] |
| ChEMBL | Agonist activity at recombinant human CB1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 5 mins by cAMP-competition binding assay | F | 5 | pEC50 | >10000 | nM | EC50 | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Displacement of [3H]CP55,940 from recombinant human CB2 receptor expressed in CHO cells after 2 hrs by liquid scintillation counting | B | 5.25 | pKi | 5610 | nM | Ki | ACS Med Chem Lett (2013) 4: 41-45 [PMID:24900561] |
| ChEMBL | Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cell membranes after 2 hrs | B | 8.25 | pKi | 5.61 | nM | Ki | Eur J Med Chem (2016) 116: 252-266 [PMID:27078864] |
| Cyclooxygenase-1 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2949] [UniProtKB: P05979] | ||||||||
| ChEMBL | Inhibition of COX1 in ram seminal vesicle by enzyme immunoassay | B | 5.74 | pIC50 | 1800 | nM | IC50 | Bioorg Med Chem (2009) 17: 4459-4465 [PMID:19481465] |
| Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208] | ||||||||
| ChEMBL | Inhibition of COX2 in sheep placental vesicle by enzyme immunoassay | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem (2009) 17: 4459-4465 [PMID:19481465] |
| GABAA receptor α1 subunit/GABAA receptor γ2 subunit/GABAA receptor β2 subunit/GABA-A receptor; alpha-1/beta-2/gamma-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095172] [GtoPdb: 404, 414, 411] [UniProtKB: P14867, P18507, P47870] | ||||||||
| ChEMBL | Partial agonist activity at GABAAalpha1beta2gamma2s receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as induction of chloride current by two-microelectrode voltage-clamp method | B | 4.12 | pEC50 | 76200 | nM | EC50 | Bioorg Med Chem (2015) 23: 6757-6762 [PMID:26410663] |
| GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABA-A receptor alpha-1/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106151] [GtoPdb: 404, 412] [UniProtKB: P14867, P28472] | ||||||||
| ChEMBL | Modulation of GABA Aalpha1beta3 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.22 | pEC50 | 59600 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| GABAA receptor α1 subunit/GABAA receptor β2 subunit/GABA-A receptor; GABA-A site (alpha1/beta2 interface) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907597] [GtoPdb: 404, 411] [UniProtKB: P14867, P47870] | ||||||||
| ChEMBL | Modulation of GABA Aalpha1beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.41 | pEC50 | 39300 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| GABAA receptor α1 subunit/GABAA receptor β1 subunit/Gamma-aminobutyric acid receptor subunit alpha-1/ beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885570] [GtoPdb: 404, 410] [UniProtKB: P14867, P18505] | ||||||||
| ChEMBL | Modulation of GABA Aalpha1beta1 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.24 | pEC50 | 57000 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| GABAA receptor α2 subunit/GABAA receptor β2 subunit/Gamma-aminobutyric acid receptor subunit alpha-2/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885571] [GtoPdb: 405, 411] [UniProtKB: P47869, P47870] | ||||||||
| ChEMBL | Modulation of GABA Aalpha2beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.33 | pEC50 | 46400 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| GABAA receptor α3 subunit/GABAA receptor β2 subunit/Gamma-aminobutyric acid receptor subunit alpha-3/ beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885572] [GtoPdb: 406, 411] [UniProtKB: P34903, P47870] | ||||||||
| ChEMBL | Modulation of GABA Aalpha3beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.28 | pEC50 | 52400 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| GABAA receptor α5 subunit/GABAA receptor β2 subunit/Gamma-aminobutyric acid receptor subunit alpha-5/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3885576] [GtoPdb: 408, 411] [UniProtKB: P31644, P47870] | ||||||||
| ChEMBL | Modulation of GABA Aalpha5beta2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced chloride current at holding potential -70 mV by two-microelectrode voltage clamp technique | B | 4.63 | pEC50 | 23400 | nM | EC50 | J Med Chem (2011) 54: 5349-5361 [PMID:21699169] |
| sirtuin 3/NAD-dependent deacetylase sirtuin 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4461] [GtoPdb: 2709] [UniProtKB: Q9NTG7] | ||||||||
| ChEMBL | Binding affinity to N-terminal his-tagged human SIRT3 (114 to 380 residues) assessed as dissociation constant by SPR analysis | B | 4.4 | pKd | 40000 | nM | Kd | J Med Chem (2023) 66: 9622-9641 [PMID:37439550] |
| ChEMBL | Binding affinity to human Sirt3 (118 to 399 residues) assessed as dissociation constant using 625nM acetylated MnSOD peptide as substrate by microscale thermophoresis analysis | B | 5.52 | pKd | 2990 | nM | Kd | Bioorg Med Chem (2022) 73: 116999-116999 [PMID:36191547] |
| ChEMBL | Binding affinity to human Sirt3 (118 to 399 residues) assessed as dissociation constant by microscale thermophoresis analysis | B | 6 | pKd | 1010 | nM | Kd | Bioorg Med Chem (2022) 73: 116999-116999 [PMID:36191547] |
| ChEMBL | Binding affinity to human Sirt3 (118 to 399 residues) assessed as dissociation constant using acetylated MnSOD peptide as substrate by microscale thermophoresis analysis | B | 6.01 | pKd | 970 | nM | Kd | Bioorg Med Chem (2022) 73: 116999-116999 [PMID:36191547] |
| ChEMBL | Binding affinity to human Sirt3 (118 to 399 residues) assessed as dissociation constant of ternary complex using acetylated MnSOD peptide as substrate in presence of OAADPr by microscale thermophoresis analysis | B | 6.54 | pKd | 290 | nM | Kd | Bioorg Med Chem (2022) 73: 116999-116999 [PMID:36191547] |
| ChEMBL | Activation of recombinant human SIRT3 assessed as lysyl deacetylase activity using (Gln-Pro-Lys-Lys(Ac)) peptide substrate by fluorescent assay | B | 6.77 | pEC50 | 170 | nM | EC50 | J Med Chem (2021) 64: 14192-14216 [PMID:34605238] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] | ||||||||
| ChEMBL | Inhibition of Influenza A virus (A/Puerto Rico/8/1934(H1N1)) neuraminidase by chemiluminescence based assay | B | 4.52 | pIC50 | 30100 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
| ChEMBL | Inhibition of oseltamivir-resistant Influenza A virus H1N1 B/55/08 neuraminidase by chemiluminescence based assay | B | 5.86 | pIC50 | 1390 | nM | IC50 | J Nat Prod (2014) 77: 563-570 [PMID:24313801] |
| Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793] | ||||||||
| ChEMBL | Agonist activity at RXRalpha in HEK293 cells assessed as transcriptional activation after 48 hrs by luciferase reporter gene assay | F | 4.93 | pEC50 | 11800 | nM | EC50 | J Nat Prod (2010) 73: 1332-1336 [PMID:20695472] |
| CoV Spike glycoprotein/Spike glycoprotein in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662936] [GtoPdb: 3114] [UniProtKB: P0DTC2] | ||||||||
| ChEMBL | Binding affinity to SARS-CoV-2 spike protein receptor-binding domain assessed as equilibrium dissociation constant by biolayer interferometry assay | B | 4.6 | pKd | 25010 | nM | Kd | Bioorg Med Chem (2022) 67: 116838-116838 [PMID:35617790] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
