RIPK1 inhibitor 22b [Ligand Id: 10155] activity data from GtoPdb

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  • fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916]
Created with Highcharts 10.3.3ValuesChart context menufms related receptor tyrosine kinase 4pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629]
Created with Highcharts 10.3.3ValuesChart context menuneurotrophic receptor tyrosine kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620]
Created with Highcharts 10.3.3ValuesChart context menuneurotrophic receptor tyrosine kinase 2pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
Created with Highcharts 10.3.3ValuesChart context menuneurotrophic receptor tyrosine kinase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530]
Created with Highcharts 10.3.3ValuesChart context menuAXL receptor tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866]
Created with Highcharts 10.3.3ValuesChart context menuMER proto-oncogene, tyrosine kinasepKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • discoidin domain receptor tyrosine kinase 1 in Human [GtoPdb: 1843] [UniProtKB: Q08345]
Created with Highcharts 10.3.3ValuesChart context menudiscoidin domain receptor tyrosine kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • eukaryotic translation initiation factor 2 alpha kinase 1 in Human [GtoPdb: 2015] [UniProtKB: Q9BQI3]
Created with Highcharts 10.3.3ValuesChart context menueukaryotic translation initiation factor 2 alpha kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • mitogen-activated protein kinase kinase kinase kinase 5 in Human [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
Created with Highcharts 10.3.3ValuesChart context menumitogen-activated protein kinase kinase kinase kinase 5pKd HumanpKi HumanpIC50 HumanpEC50 Human02468Highcharts.com
  • receptor interacting serine/threonine kinase 1 in Human [GtoPdb: 2189] [UniProtKB: Q13546]
Created with Highcharts 10.3.3ValuesChart context menureceptor interacting serine/threonine kinase 1pKd HumanpKi HumanpIC50 HumanpEC50 Human0246810Highcharts.com
  • receptor interacting serine/threonine kinase 3 in Human [GtoPdb: 2191] [UniProtKB: Q9Y572]
Created with Highcharts 10.3.3ValuesChart context menureceptor interacting serine/threonine kinase 3pKd HumanpKi HumanpIC50 HumanpEC50 Human0123456Highcharts.com
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916]
GtoPdb - - 7.7 pIC50 20 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629]
GtoPdb - - 7.59 pIC50 26 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620]
GtoPdb - - 8.1 pIC50 8 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288]
GtoPdb - - 8.15 pIC50 7 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530]
GtoPdb - - 7.46 pIC50 35 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866]
GtoPdb - - 7.54 pIC50 29 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
GtoPdb - - 7.54 pIC50 29 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
discoidin domain receptor tyrosine kinase 1 in Human [GtoPdb: 1843] [UniProtKB: Q08345]
GtoPdb - - 7.46 pIC50 35 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
eukaryotic translation initiation factor 2 alpha kinase 1 in Human [GtoPdb: 2015] [UniProtKB: Q9BQI3]
GtoPdb - - 7.59 pIC50 26 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
mitogen-activated protein kinase kinase kinase kinase 5 in Human [GtoPdb: 2089] [UniProtKB: Q9Y4K4]
GtoPdb - - 7.43 pIC50 37 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
receptor interacting serine/threonine kinase 1 in Human [GtoPdb: 2189] [UniProtKB: Q13546]
GtoPdb Binding affinity value. - 8.36 pKd 4.4 nM Kd J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
GtoPdb Inhibition of RIPK1 enzymatic activity in vitro determined using Eurofins' KinaseProfiler assay. - 7.96 pIC50 11 nM IC50 J Med Chem (2018) 61: 11398-11414 [PMID:30480444]
receptor interacting serine/threonine kinase 3 in Human [GtoPdb: 2191] [UniProtKB: Q9Y572]
GtoPdb - - 5.14 pKd 7200 nM Kd J Med Chem (2018) 61: 11398-11414 [PMID:30480444]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.