RIPK1 inhibitor 22b [Ligand Id: 10155] activity data from GtoPdb
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| fms related receptor tyrosine kinase 4 in Human [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
| GtoPdb | - | - | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| neurotrophic receptor tyrosine kinase 1 in Human [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| GtoPdb | - | - | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| neurotrophic receptor tyrosine kinase 2 in Human [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| neurotrophic receptor tyrosine kinase 3 in Human [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| AXL receptor tyrosine kinase in Human [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| GtoPdb | - | - | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| MER proto-oncogene, tyrosine kinase in Human [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| GtoPdb | - | - | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| GtoPdb | - | - | 7.54 | pIC50 | 29 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| discoidin domain receptor tyrosine kinase 1 in Human [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
| GtoPdb | - | - | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| eukaryotic translation initiation factor 2 alpha kinase 1 in Human [GtoPdb: 2015] [UniProtKB: Q9BQI3] | ||||||||
| GtoPdb | - | - | 7.59 | pIC50 | 26 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| mitogen-activated protein kinase kinase kinase kinase 5 in Human [GtoPdb: 2089] [UniProtKB: Q9Y4K4] | ||||||||
| GtoPdb | - | - | 7.43 | pIC50 | 37 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| receptor interacting serine/threonine kinase 1 in Human [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| GtoPdb | Binding affinity value. | - | 8.36 | pKd | 4.4 | nM | Kd | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| GtoPdb | Inhibition of RIPK1 enzymatic activity in vitro determined using Eurofins' KinaseProfiler assay. | - | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
| receptor interacting serine/threonine kinase 3 in Human [GtoPdb: 2191] [UniProtKB: Q9Y572] | ||||||||
| GtoPdb | - | - | 5.14 | pKd | 7200 | nM | Kd | J Med Chem (2018) 61: 11398-11414 [PMID:30480444] |
Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.
